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Particulate
Interactions in Inhalation Systems
The characteristic properties of dry powder and suspension based pressurised metered dose inhaler formulations are governed by a fine balance of the cohesive (drug-drug) and adhesive (drug-excipient, drug-device) interactions. Our research interests involve characterising the relationship between short-range and long-range interfacial forces with aerosol behaviour. The refinement of the colloidal probe AFM technique, led by the pharmaceutical surface science research group, has provided a novel preformulation tool for characterising the physico-chemical properties of active pharmaceutical ingredients within solid-state formulation preparations and a means of determining the key attributes which control and enhance their behaviour.
A Colloid
Drug Probe
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