Particle Engineering Processing

Although constructive processes for the production of solid drug particles within an optimum particle size range are available, there remains a need to develop novel particle engineering technologies with a greater control of the physico-chemical properties while maintaining high throughput, low cost and industrial scalability.

Our approach has utilised the information available at the single particle level to develop several novel technologies in the area of particle engineering. This includes the novel production of spherical crystalline particles through a combination of solution atomisation and controlled crystallisation by ultrasonication (SACS). The SACS process has been utilised as a single step (continuous or batch) operation which can control and modify the size, shape, while influencing the surface roughness and polymorphic form of drug crystals in a single droplet to particle (SDP) operation (see example below).

Spherical crystalline particles engineered via SACS