4 South .044
Current Lab Members
- Chris Bryant (PhD student)
- Kate Burley (PhD student)
- Gail Doughton (PhD student)
- Tulay Gulsen (PhD student)
- Ben Sharpe (PhD student)
Our research is supported by the Annett Trust, BBSRC, MRC and the Turkish Government.
Dr Andrew Chalmers
Epithelial cells are found in many of our organs including the lungs, intestines, pancreas and prostate. Our goal is to understand the regulation of these cells, as around 80% of tumours arise from epithelial cells.
We are specifically interested in exploring the relationships that exist between the regulation of cell fate, cell polarity and cell proliferation in normal and cancerous epithelial cells.
CiteAb - Antibody search tool
We are also developing CiteAb a publication based antibody search tool that helps researchers find antibodies suitable for their research. Users can search more than 400,000 antibodies, filter results based on application and species reactivity, and then link to the antibody supplier’s website for further details. Our aim is to promote research by making this the world’s best antibody search tool.
Please visit our website - www.citeab.co.uk
Gulsen, T., Hadjicosti, I., Li, Y., Zhang, X., Whitley, P. R. and Chalmers, A. D., 2016. Truncated RASSF7 promotes centrosomal defects and cell death. Developmental Biology, 409 (2), pp. 502-517.
Chalmers, A. and Bradbury, A., 2015. Reproducibility: Standardize antibodies used in research. Nature, 518 (7537), 27 - 29.
Helsby, M. A., Leung, M. Y. and Chalmers, A. D., 2014. The F1000Research Antibody Validation Article Collection. F1000 Research, 3 (241).
Helsby, M. A., Leader, P. M., Fenn, J. R., Gulsen, T., Bryant, C., Doughton, G., Sharpe, B., Whitley, P., Caunt, C. J., James, K., Pope, A. D., Kelly, D. H. and Chalmers, A. D., 2014. CiteAb:A searchable antibody database that ranks antibodies by the number of times they have been cited. BMC Cell Biology, 15 (1), 6.
Doughton, G., Wei, J., Tapon, N., Welham, M. J. and Chalmers, A. D., 2014. Formation of a polarised primitive endoderm layer in embryoid bodies requires Fgfr/Erk signalling. PLoS ONE, 9 (4), e95434.
Sharpe, B., Beresford, M., Bowen, R., Mitchard, J. and Chalmers, A. D., 2013. Searching for prostate cancer stem cells:markers and methods. Stem Cell Reviews and Reports, 9 (5), pp. 721-730.
Comber, K., Huelsmann, S., Evans, I., Sánchez-Sánchez, B. J., Chalmers, A., Reuter, R., Wood, W. and Martín-Bermudo, M. D., 2013. A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration. Journal of Cell Science, 126 (15), pp. 3475-3484.
Helsby, M., Fenn, J. and Chalmers, A., 2013. Reporting research antibody use:How to increase experimental reproducibility. F1000 Research, 2, 153 v2.
Dukes, J. D., Whitley, P. and Chalmers, A. D., 2012. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE, 7 (3), e28659.
Chalmers, A. and Whitley, P., 2012. Continuous endocytic recycling of tight junction proteins: how and why? Essays in Biochemistry, 53, pp. 41-54.
Chalmers, A., 2012. Formation and Maintenance of Differentiated Epithelial Cells. In: 2nd South West Regional Regenerative Medicine Meeting, 2012-07-01.
Dukes, J. D., Fish, L., Richardson, J. D., Blaikley, E., Burns, S., Caunt, C. J., Chalmers, A. D. and Whitley, P., 2011. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Molecular Biology of the Cell, 22 (17), pp. 3192-3205.
Hill, V. K., Underhill-Day, N., Krex, D., Robel, K., Sangan, C. B., Summersgill, H. R., Morris, M., Gentle, D., Chalmers, A. D., Maher, E. R. and Latif, F., 2011. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. Oncogene, 30 (8), pp. 978-989.
Recino, A., Sherwood, V., Flaxman, A., Cooper, W. N., Latif, F., Ward, A. and Chalmers, A. D., 2010. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Biochemical Journal, 430 (2), pp. 207-213.
Sherwood, V., Recino, A., Jeffries, A., Ward, A. and Chalmers, A. D., 2010. The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation. Biochemical Journal, 425 (2), pp. 303-311.
Lock, F. E., Underhill-Day, N., Dunwell, T., Matallanas, D., Cooper, W., Hesson, L., Recino, A., Ward, A., Pavlova, T., Zabarovsky, E., Grant, M. M., Maher, E. R., Chalmers, A. D., Kolch, W. and Latif, F., 2010. The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways. Oncogene, 29 (30), pp. 4307-4316.
Sabherwal, N., Tsutsui, A., Hodge, S., Wei, J., Chalmers, A. D. and Papalopulu, N., 2009. The apicobasal polarity kinase aPKC functions as a nuclear determinant and regulates cell proliferation and fate during Xenopus primary neurogenesis. Development, 136 (16), pp. 2767-2777.
Hesson, L. B., Dunwell, T. L., Cooper, W. N., Catchpoole, D., Brini, A. T., Chiaramonte, R., Griffiths, M., Chalmers, A. D., Maher, E. R. and Latif, F., 2009. The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias. Molecular Cancer, 8 (42).
Sabherwal, N., Chalmers, A. D. and Papalopulu, N., 2009. 21-P020 The apical–basal polarity kinase aPKC functions as a nuclear determinant and regulates cell proliferation and fate during Xenopus neurogenesis. Mechanisms of Development, 126 (Suppl 1), S319.
Wei, J., Sanchez Ripoll, Y., Welham, M. and Chalmers, A. D., 2009. Bmp4 promotes differentiation of the first vertebrate epithelium. Mechanisms of Development, 126 (Suppl S), S271.
Sherwood, V., Manbodh, R., Sheppard, C. and Chalmers, A. D., 2008. RASSF7 is a member of a new family of RAS association domain- containing proteins and is required for completing mitosis. Molecular Biology of the Cell, 19 (4), pp. 1772-1782.