Department of Biology & Biochemistry

jason-wolf 

Professor of Evolutionary Genetics

4 South 0.14

Email: J.B.Wolf@bath.ac.uk

Tel: +44 (0) 1225 385012 

 

Professor Jason Wolf 

Profile

Our research is focused on understanding the evolutionary genetics of complex characters, with a special focus given to understanding the influence that frequently ignored or under-appreciated sources of genetic variation have on the genotype-phenotype relationship and how this, in turn, influences evolutionary processes. We integrate theoretical, computational and empirical quantitative and population genetic techniques to achieve our goals. Current research is primarily focused in three areas.
 

1) The evolution and genetic architecture of genomic imprinting. On the evolutionary side we have been focused on understanding how various processes can favour the evolution of imprinted gene expression. Many of these processes involve interaction effects, where genomic imprinting enhances the evolution of genetic coadaptation. On the genetic architecture side, we have been working to understand how imprinted genes contribute to patterns of phenotypic variation in populations. We are also interested in how imprinted loci contribute to the dynamics of phenotypic evolution.

2) The genetics of social evolution (and closely related concepts). Much of this work has been focused specifically on understanding the genetics and evolution of maternal effects, where genes in mothers influence the expression of traits in their offspring. Along these lines we have been working on evolutionary models that incorporate various types of maternal effects, and computational approaches to determining the contribution of these effects to patterns of variation. We have also been applying approaches to studying the genetics of social evolution to understand ecological interactions between plants, especially competitive interactions, and the evolutionary genetics of conflict and cooperation using the social amoeba Dictyostelium discoideum as a model species.

3) The genetic architecture and evolution of pleiotropy (where one gene affects the expression of multiple traits). We are working with a number of experimental systems to understand how pleiotropy constrains evolution and how various types of genetic variation can allow pleiotropic patterns to evolve.

For more information see www.evolutionarygenetics.org.

Publications

Gruenheit, N., Parkinson, K., Stewart, B., Howie, J. A., Wolf, J. B. and Thompson, C. R. L., 2017. A polychromatic 'greenbeard' locus determines patterns of cooperation in a social amoeba. Nature Communications, 8, 14171.

Wolf, J. B. and Wade, M. J., 2016. Evolutionary genetics of maternal effects. Evolution, 70 (4), pp. 827-839.

Wolf, J. B., Howie, J. A., Parkinson, K., Gruenheit, N., Melo, D., Rozen, D. and Thompson, C. R. L., 2015. Fitness trade-offs result in the illusion of social success. Current Biology, 25 (8), pp. 1086-1090.

Wolf, J. B., Cowley, M. and Ward, A., 2015. Coadaptation between mother and offspring:why not? PLoS Biology, 13 (3), e1002085.

Leamy, L. J., Klingenberg, C. P., Sherratt, E., Wolf, J. B. and Cheverud, J. M., 2015. The genetic architecture of fluctuating asymmetry of mandible size and shape in a population of mice:another look. Symmetry, 7 (1), pp. 146-163.

O'Brien, E., Hunt, J. and Wolf, J. B., 2015. Quantitative genetic variation and heritability. Oxford Bibliographies in Evolutionary Biology

Spencer, H. G. and Wolf, J. B., 2014. Genomic imprinting:Theories and data. Heredity, 113 (2), pp. 93-95.

Wolf, J. B. and Brandvain, Y., 2014. Gene interactions in the evolution of genomic imprinting. Heredity, 113, pp. 129-137.

Wolf, J. B., Oakey, R. J. and Feil, R., 2014. Imprinted gene expression in hybrids:perturbed mechanisms and evolutionary implications. Heredity, 113, pp. 167-175.

Patten, M. M., Ross, L., Curley, J. P., Queller, D. C., Bonduriansky, R. and Wolf, J. B., 2014. The evolution of genomic imprinting:Theories, predictions and empirical tests. Heredity, 113 (2), pp. 119-128.

Pitchers, W., Wolf, J.B., Tregenza, T., Hunt, J. and Dworkin, I., 2014. Evolutionary rates for multivariate traits:The role of selection and genetic variation. Philosophical Transactions of the Royal Society B - Biological Sciences, 369 (1649), 20130252.

McGlothlin, J.W., Wolf, J.B., Brodie III, E.D. and Moore, A.J., 2014. Quantitative genetic versions of Hamilton's rule with empirical applications. Philosophical Transactions of the Royal Society B - Biological Sciences, 369 (1642), 20130358.

Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B. and Ward, A., 2014. Developmental Programming Mediated by Complementary Roles of Imprinted Grb10 in Mother and Pup. PLoS Biology, 12 (2), e1001799.

Lawson, H. A., Cheverud, J. M. and Wolf, J. B., 2013. Genomic imprinting and parent-of-origin effects on complex traits. Nature Reviews Genetics, 14 (9), pp. 609-617.

Wolf, J. B., 2013. Evolution of genomic imprinting as a coordinator of coadapted gene expression. Proceedings of the National Academy of Sciences of the United States of America, 110 (13), pp. 5085-5090.

Wolf, J. and Cheverud, J. M., 2012. Detecting maternal-effect loci by statistical cross-fostering. Genetics, 191 (1), pp. 261-277.

Hager, R., Cheverud, J. M. and Wolf, J. B., 2012. Genotype-dependent responses to levels of sibling competition over maternal resources in mice. Heredity, 108 (5), pp. 515-520.

Lawson, H. A., Cady, J. E., Partridge, C., Wolf, J. B., Semenkovich, C. F. and Cheverud, J. M., 2011. Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations. Plos Genetics, 7 (9), e1002256.

Wolf, J. B., Mutic, J. J. and Kover, P. X., 2011. Functional genetics of intraspecific ecological interactions in Arabidopsis thaliana. Philosophical Transactions of the Royal Society B - Biological Sciences, 366 (1569), pp. 1358-1367.

Norgard, E. A., Lawson, H. A., Pletscher, L. S., Wang, B., Brooks, V. R., Wolf, J. B. and Cheverud, J. M., 2011. Genetic factors and diet affect long-bone length in the F-34 LG,SM advanced intercross. Mammalian Genome, 22 (3-4), pp. 178-196.

Lawson, H. A., Lee, A., Fawcett, G. L., Wang, B., Pletscher, L. S., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B., Semenkovich, C. F. and Cheverud, J. M., 2011. The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J x SM/J murine model. Mammalian Genome, 22 (3-4), pp. 197-208.

Parkinson, K., Buttery, N. J., Wolf, J. B. and Thompson, C. R. L., 2011. A simple mechanism for complex social behavior. PLoS Biology, 9 (3), e1001039.

Cheverud, J. M., Lawson, H. A., Fawcett, G. L., Wang, B., Pletscher, L. S., Fox, A. R., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B. and Semenkovich, C. F., 2011. Diet-dependent genetic and genomic imprinting effects on obesity in mice. Obesity, 19 (1), pp. 160-170.

Wolf, J. B., Leamy, L. J., Roseman, C. C. and Cheverud, J. M., 2011. Disentangling prenatal and postnatal maternal genetic effects reveals persistent prenatal effects on offspring growth in mice. Genetics, 189 (3), pp. 1069-82.

Lawson, H. A., Zelle, K. M., Fawcett, G. L., Wang, B., Pletscher, L. S., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B., Semenkovich, C. F. and Cheverud, J. M., 2010. Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model. Journal of Lipid Research, 51 (10), pp. 2976-2984.

McGlothlin, J. W., Moore, A. J., Wolf, J. B. and Brodie, E. D., 2010. Interacting phenotypes and the evolutionary process III: social evolution. Evolution, 64 (9), pp. 2558-2574.

Buttery, N. J., Thompson, C. R. L. and Wolf, J. B., 2010. Complex genotype interactions influence social fitness during the developmental phase of the social amoeba Dictyostelium discoideum. Journal of Evolutionary Biology, 23 (8), pp. 1664-1671.

Bleakley, B. H., Wolf, J. B. and Moore, A. J., 2010. Quantitative genetics of social behavior. In: Szekely, T., Komdeur, J. and Moore, A. J., eds. Social Behaviour: Genes, Ecology and Evolution. Cambridge University Press.

Fawcett, G. L., Jarvis, J. P., Roseman, C. C., Wang, B., Wolf, J. B. and Cheverud, J. M., 2010. Fine-mapping of obesity-related quantitative trait loci in an F-9/10 advanced intercross line. Obesity, 18 (7), pp. 1383-1392.

Norgard, E. A., Jarvis, J. P., Roseman, C. C., Maxwell, T. J., Kenney-Hunt, J. P., Samocha, K. E., Pletscher, L. S., Wang, B., Fawcett, G. L., Leatherwood, C. J., Wolf, J. B. and Cheverud, J. M., 2009. Replication of long-bone length QTL in the F9-F10 LG,SM advanced intercross. Mammalian Genome, 20 (4), pp. 224-235.

Hager, R., Cheverud, J. M. and Wolf, J. B., 2009. Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice. Proceedings of the Royal Society B: Biological Sciences, 276 (1669), pp. 2949-2954.

Buttery, N. J., Rozen, D. E., Wolf, J. B. and Thompson, C. R. L., 2009. Quantification of social behavior in D. discoideum Reveals complex fixed and facultative strategies. Current Biology, 19 (16), pp. 1373-1377.

Cheverud, J. M. and Wolf, J. B., 2009. Genetics and evolutionary consequences of maternal effects. In: Maestripieri, D. and Mateo, J. M., eds. Maternal Effects in Mammals. Chicago University Press, pp. 11-37.

Wolf, J. B., 2009. Cyto-nuclear interactions can favor the evolution of genomic imprinting. Evolution, 63 (5), pp. 1364-1371.

Wolf, J. B. and Wade, M. J., 2009. What are maternal effects (and what are they not)? Philosophical Transactions of the Royal Society B - Biological Sciences, 364 (1520), pp. 1107-1115.

Hager, R., Cheverud, J. M. and Wolf, J. B., 2009. Relative contribution of additive, dominance and imprinting effects to phenotypic variation in body size and growth between divergent selection lines of mice. Evolution, 63 (5), 1118 -1128.

Wolf, J. B. and Cheverud, J. M., 2009. A framework for detecting and characterizing genetic background-dependent imprinting effects. Mammalian Genome, 20 (9-10), pp. 681-698.

Wolf, J. B. and Hager, R., 2009. Selective abortion and the evolution of genomic imprinting. Journal of Evolutionary Biology, 22 (12), pp. 2519-2523.

Wolf, J. B., Hager, R. and Cheverud, J. M., 2008. Genomic imprinting effects on complex traits:A phenotype-based perspective. Epigenetics, 3 (6), pp. 295-299.

Hager, R., Cheverud, J. M., Leamy, L. J. and Wolf, J. B., 2008. Sex dependent imprinting effects on complex traits in mice. BMC Evolutionary Biology, 8 (1), p. 303.

Wolf, J. B., Harris, W. E. and Royle, N. J., 2008. The capture of heritable variation for genetic quality through social competition. Genetica, 134 (1), pp. 89-97.

Leamy, L. J., Klingenberg, C. P., Sherratt, E., Wolf, J. B. and Cheverud, J. M., 2008. A search for quantitative trait loci exhibiting imprinting effects on mouse mandible size and shape. Heredity, 101 (6), pp. 518-526.

Fawcett, G. L., Roseman, C. C., Jarvis, J. P., Wang, B., Wolf, J. B. and Cheverud, J. M., 2008. Genetic architecture adiposity and organ weight using combined generation QTL analysis. Obesity, 16 (8), pp. 1861-1868.

Wolf, J. B., 2008. The role of social effects in selection for animal improvement. Brazilian Journal of Animal Science, 37, pp. 137-142.

Wolf, J. B., Cheverud, J. M., Roseman, C. and Hager, R., 2008. Genome-wide analysis reveals a complex pattern of genomic imprinting in mice. Plos Genetics, 4 (6), e1000091.

Kenney-Hunt, J. P., Wang, B., Norgard, E. A., Fawcett, G., Falk, D., Pletscher, L. S., Jarvis, J. P., Roseman, C., Wolf, J. B. and Cheverud, J. M., 2008. Pleiotropic Patterns of Quantitative Trait Loci for 70 Murine Skeletal Traits. Genetics, 178 (4), pp. 2275-2288.

Cheverud, J. M., Hager, R., Roseman, C., Fawcett, G., Wang, B. and Wolf, J. B., 2008. Genomic imprinting effects on adult body composition in mice. Proceedings of the National Academy of Sciences of the United States of America, 105 (11), pp. 4253-4258.

Hager, R., Cheverud, J. M. and Wolf, J. B., 2008. Maternal effects as the cause of parent-of-origin dependent effects that mimic genomic imprinting. Genetics, 178 (3), pp. 1755-1762.

Harris, W. E., McKane, A. J. and Wolf, J. B., 2008. The maintenance of heritable variation through social competition. Evolution, 62 (2), pp. 337-347.

This list was generated on Wed Aug 16 14:04:17 2017 IST.

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