Department of Biology & Biochemistry
Julien Licchesi

Lecturer in Cellular Biochemistry

4 South 0.46

Email: j.licchesi@bath.ac.uk

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Dr Julien Licchesi

Profile

Research Interests

Ubiquitin is a versatile post-translational modification which regulates most, if not all, cellular processes including transcription, DNA repair and the cell cycle. This highly conserved protein is best known for its role in mediating protein degradation as part of the ubiquitin-proteasome system. However ubiquitin also has non-degradative functions including in protein trafficking and protein complex formation. Protein ubiquitylation is achieved through a cascade of enzymatic reactions involving an E1-activating enzyme, E2-conjugating enzymes and E3 ubiquitin ligases and which culminates in the covalent attachment of one or more ubiquitin molecules (i.e. ubiquitin chains) onto lysine residue(s) of a protein target. The assembly of ubiquitin into chains requires the formation of an isopeptide bond between any of the seven lysines (K6, K11, K27, K29, K33, K48 and K63) or the N-terminus (i.e. linear ubiquitin) of an acceptor ubiquitin and the C-terminus of a donor ubiquitin. Therefore as many as eight linkage types can be used to assemble homotypic, heterotypic or even branched ubiquitin chains onto protein targets. These linkage-specific ubiquitin chains have different structural and biochemical properties, are regulated by dedicated E3 ubiquitin ligases and deubiquitylases, and modulate specific cell signalling events.

Goals

To characterise the biochemical properties and cellular functions of members of the HECT family of E3 ligases and the OTU family of deubiquitylases in normal and disease states, including cancer and neurodegenerative diseases.

Academic Biography

  • Lecturer in Cellular Biochemistry, University of Bath (from June 2013)
  • Postdoctoral Fellow MRC-Laboratory of Molecular Biology, Cambridge, UK (2007-2013)
  • Postdoctoral Fellow Johns Hopkins University, Baltimore, USA (2003-2007)
  • PhD Cranfield University, UK (1999-2003)

Publications

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