Department of Biology & Biochemistry


4 South 0.39


Tel: +44 (0) 1225 385046 


Dr Makoto Furutani-Seiki 


Research interests

In our body, cells generated from stem cells exhibit dynamic cell behaviors in the course of formation and maintenance of organs, such as cell adhesion, migration, polarization, proliferation or death.

Insights into such cell behaviors and lineages underlying human diseases or regeneration are fundamental, since such analyses allow definitive identification of stem or trans-differentiating cells, or validation of the effects of drugs at the cellular level in vivo. However, dynamic cellular basis of diseases remains elusive due to the difficulties of tracking cell behaviors and cell lineages in vivo in conventional mammalian system.

The aim of our research is to understand what defects in such cell behaviors and cell lineages underlie human diseases and regeneration. We have been using Medaka fish and zebrafish to address these questions.

We have been analysing fish models of cancer and regeneration to discover cell behavioral alterations underlying human diseases and regeneration in the following specific projects.

1. Mutations affecting epithelial organ integrity
2. Cancer models: APC, p53 knockout mutants
3. Liver regeneration therapy model
4. Validation of pro-drugs in the context of in vivo cell behaviours using GFP-transgenics.

Academic bibliography

• Professor, Kumamoto University 2007
• Group leader, ERATO, JST, 2000-2007
• Group leader. Freiburg University, 1997-2000
• Post-doc, Max-Planck-Institute für Enwicklungsbiologie, 1992-1997
• Ph.D. (University of Tokyo) 1989


Asaoka, Y., Nagai, Y., Namae, M., Furutani-Seiki, M. and Nishina, H., 2016. SLC7 family transporters control the establishment of left-right asymmetry during organogenesis in medaka by activating mTOR signaling. Biochemical and Biophysical Research Communications, 474 (1), pp. 146-153.

Fujisawa, K., Terai, S., Matsumoto, T., Takami, T., Yamamoto, N., Nishina, H., Furutani-Seiki, M. and Sakaida, I., 2015. Evidence for a role of the transcriptional regulator Maid in tumorigenesis and aging. PLoS ONE, 10 (6), e0129950.

Porazinski, S., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, S. F. G., Osada, Y., Asaka, S., Momoi, A., Linton, S., Miesfeld, J. B., Link, B. A., Senga, T., Castillo-Morales, A., Urrutia, A. O., Shimizu, N., Nagase, H., Matsuura, S., Bagby, S., Kondoh, H., Nishina, H., Heisenberg, C. P. and Furutani-Seiki, M., 2015. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature, 521 (7551), pp. 217-221.

Santos Cravo, A., Mrsny, R., Carter, E., Harvey, E., Furutani-Seiki, M. and Erkan, M., 2015. Hippo pathway elements co-localize with occludin:a possible sensor system in pancreatic epithelial cells. Tissue Barriers, 3 (3), e1037948.

Asaoka, Y., Hata, S., Namae, M., Furutani-Seiki, M. and Nishina, H., 2014. The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE, 9 (5), e97365.

Liedtke, D., Erhard, I., Abe, K., Furutani-Seiki, M., Kondoh, H. and Schartl, M., 2014. Xmrk-induced melanoma progression is affected by Sdf1 signals through Cxcr7. Pigment Cell & Melanoma Research, 27 (2), pp. 221-233.

Lee, M.-J., Ran Byun, M., Furutani-Seiki, M., Hong, J.-H. and Jung, H.-S., 2014. YAP and TAZ regulate skin wound healing. Journal Of Investigative Dermatology, 134 (2), pp. 518-525.

Hata, S., Hirayama, J., Kajiho, H., Nakagawa, K., Hata, Y., Katada, T., Furutani-seiki, M. and Nishina, H., 2012. A novel acetylation cycle of the transcription co-activator Yes-associated protein that is downstream of the Hippo pathway is triggered in response to SN2 alkylating agents. Journal of Biological Chemistry, 287, pp. 22089-22098.

Cherrett, C., Furutani-Seiki, M. and Bagby, S., 2012. The Hippo pathwaya:Key interaction and catalytic domains in organ growth control, stem cell self-renewal and tissue regeneration. Essays in Biochemistry, 53 (1), pp. 111-127.

Miyamoto, T., Porazinski, S., Wang, H., Borovina, A., Ciruna, B., Shimizu, A., Kajii, T., Kikuchi, A., Furutani-Seiki, M. and Matsuura, S., 2011. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Human Molecular Genetics, 20 (10), pp. 2058-2070.

Webb, C., Upadhyay, A., Giuntini, F., Eggleston, I., Furutani-Seiki, M., Ishima, R. and Bagby, S., 2011. Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway. Biochemistry, 50 (16), pp. 3300-3309.

Porazinski, S., Wang, H. and Furutani-Seiki, M., 2011. Essential techniques for introducing medaka to a zebrafish laboratory—towards the combined use of medaka and zebrafish for further genetic dissection of the function of the vertebrate genome. In: Pelegri, F. J., ed. Vertebrate Embryogenesis.Vol. 770. New York: Humana Press, pp. 211-241.

Miyamoto, T., Furuse, M. and Furutani-Seiki, M., 2011. In vivo imaging of tight junctions using claudin-EGFP transgenic medaka. In: Kursad, T., ed. Claudins.Vol. 762. New York: Humana Press, pp. 171-178.

Porazinski, S. R., Wang, H. and Furutani-Seiki, M., 2010. Microinjection of medaka embryos for use as a model genetic organism. Journal of Visualized Experiments, 2010 (46), e1937.

Negishi, T., Nagai, Y., Asaoka, Y., Ohno, M., Namae, M., Mitani, H., Sasaki, T., Shimizu, N., Terai, S., Sakajda, I., Kondoh, H., Katada, T., Furutani-Seiki, M. and Nishina, H., 2010. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in Medaka. Hepatology, 51 (3), pp. 1037-1045.

Seo, J., Asaoka, Y., Nagai, Y., Hirayama, J., Yamasaki, T., Namae, M., Ohata, S., Shimizu, N., Negishi, T., Kitagawa, D., Kondoh, H., Furutani-Seiki, M., Penninger, J. M., Katada, T. and Nishina, H., 2010. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Journal of Cellular Biochemistry, 110 (4), pp. 1022-1037.

Matsumoto, T., Terai, S., Oishi, T., Kuwashiro, S., Fujisawa, K., Yamamoto, N., Fujita, Y., Hamamoto, Y., Furutani-Seiki, M., Nishina, H. and Sakaida, I., 2010. Medaka as a model for human nonalcoholic steatohepatitis. Disease Models & Mechanisms, 3 (7-8), pp. 431-440.

Nagai, Y., Asaoka, Y., Namae, M., Saito, K., Momose, H., Mitani, H., Furutani-Seiki, M., Katada, T. and Nishina, H., 2010. The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochemical and Biophysical Research Communications, 396 (4), pp. 887-893.

Porazinski, S., Wang, H. and Furutani-Seiki, M., 2010. Dechorionation of medaka embryos and cell transplantation for the generation of chimeras. Journal of Visualized Experiments, 46.

Miyamoto, T., Momoi, A., Kato, K., Kondoh, H., Tsukita, S., Furuse, M. and Furutani-Seiki, M., 2009. Generation of transgenic medaka expressing claudin7-EGFP for imaging of tight junctions in living medaka embryos. Cell and Tissue Research, 335 (2), pp. 465-471.

Iwanami, N., Okada, M., Hoa, V. Q., Seo, Y., Mitani, H., Sasaki, T., Shimizu, N., Kondoh, H., Furutani-Seiki, M. and Takahama, Y., 2009. Ethylnitrosourea-induced thymus-defective mutants identify roles of KIAA1440, TRRAP, and SKIV2L2 in teleost organ development. European Journal of Immunology, 39 (9), pp. 2606-2616.

Iwanami, N., Higuchi, T., Sasano, Y., Fujiwara, T., Hoa, V. Q., Okada, M., Talukder, S. R., Kunimatsu, S., Li, J., Saito, F., Bhattacharya, C., Matin, A., Sasaki, T., Shimizu, N., Mitani, H., Himmelbauer, H., Momoi, A., Kondoh, H., Furutani-Seiki, M. and Takahama, Y., 2008. WDR55 is a nucleolar modulator of ribosomal RNA synthesis, cell cycle progression, and teleost organ development. Plos Genetics, 4 (8), e1000171.

Sasado, T., Yasuoka, A., Abe, K., Mitani, H., Furutani-Seiki, M., Tanaka, M. and Kondoh, H., 2008. Distinct contributions of CXCR4b and CXCR7/RDC1 receptor systems in regulation of PGC migration revealed by medaka mutants kazura and yanagi. Developmental Biology, 320 (2), pp. 328-339.

This list was generated on Thu Jun 29 10:01:08 2017 IST.

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