Department of Biology & Biochemistry
stefan_bagby

Senior Lecturer

4 South 0.28

Email: bsssb@bath.ac.uk

Tel: +44 (0) 1225 386436 

 
 

Biography

  • BA, University of Oxford, 1988
  • DPhil, University of Oxford, 1991
  • Post-doctoral fellow, Ontario Cancer Institute and University of Toronto, 1992-1999
  • Lecturer-Senior Lecturer/Senior Tutor, University of Bath,1999 to date
 

Dr Stefan Bagby 

Profile

Current Research

Our research concerns the structure and function of proteins involved in organ size control and stem cell self-maintenance, memory and bacterial infections. We use a combination of multidimensional heteronuclear NMR spectroscopy, X-ray crystallography and other biophysical techniques and biochemical and molecular biology methods to provide novel information on protein structure, dynamics and energetics.

Organ size control and stem cell self-maintenance

The Hippo pathway is a core conserved signalling pathway and central mechanism of organ size regulation, spatial patterning, regulation of early embryo development, homeostasis, and stem cell self-renewal and differentiation. We study the structures and interactions of numerous proteins involved in this pathway and collaborate with Drosophila and fish researchers to combine in vitro with in vivo studies.

Memory

Understanding the complex mechanisms by which memories are acquired, maintained and recalled is a neuroscience holy grail. KIBRA is a postsynaptic density protein important for memory. We study the structures and interactions of KIBRA. By combining data from these molecular studies with our collaborator's cellular and in vivo data, we aim to achieve detailed understanding of KIBRA function at the postsynaptic site.

Bacterial infections

We aim to provide new insights into bacterial pathogenesis through studies of the structure and function of bacterial pathogen proteins and of their complexes with host cell target proteins. Current projects focus on proteins from Burkholderia pseudomallei and Staphylococcus aureus.

Graphene-biomolecule interactions

We are studying biomolecular interactions with graphene as the basis for new nano-devices.

Publications

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