Department of Pharmacy & Pharmacology, Unit Catalogue 2011/12
|Level:||Intermediate (FHEQ level 5)|
|Supplementary Assessment:||Like-for-like reassessment (where allowed by programme regulations)|
|Requisites:||Before taking this unit you must take PA20292|
* To familiarise the student with the mechanisms of transcriptional regulation and aberrations in these mechanisms and processes which lead to inherited diseases or the development of cancer;
* To provide basic understanding of recombinant DNA technology including the production of pharmaceutical products and as a research tool;
* To familiarise the student with the properties and potential of stem cells;
* To illustrate clinical cases through problem-based learning.
After taking this unit, the student will be able to:
* Describe the cellular pathways and mechanisms involved in the regulation of gene expression;
* Explain how genetic mutations can predispose to disease states;
* Demonstrate an understanding of recombinant DNA and stem cell technology;
* Appreciate the application of these technologies in pharmaceutical and biomedical science.
Scientific and practical skills (T/F/A)
Study skills, handling information, working with others (T/F)
Problem solving (T/F).
Impact of signalling pathways on nuclear events including regulation of gene expression through transcription factor binding. Genetic mutations, oncogenes, tumour suppressor genes and the control of cell growth. DNA cloning and the use of vectors, including plasmids and viral vectors. Manipulation of DNA including the use of restriction enzymes, DNA sequencing, hybridisation techniques, polymerase chain reaction. Stem cells and molecular techniques - RNAi and gene therapy. Problem based learning applied to relevant clinical case studies.
PA20293 is a Designated Essential Unit on the following programmes:Department of Pharmacy & Pharmacology
PA20293 is Compulsory on the following programmes:Department of Pharmacy & Pharmacology
PA20293 is Optional on the following programmes:Programmes in Natural Sciences