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Department of Pharmacy & Pharmacology, Unit Catalogue 2011/12


PA20294: Pharmacokinetics

Click here for further information Credits: 3
Click here for further information Level: Intermediate (FHEQ level 5)
Click here for further information Period: Semester 1
Click here for further information Assessment: CW30EX70
Click here for further information Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Click here for further information Requisites: Before taking this unit you must take PA10281
Click here for further information Description: Aims:
To learn pharmacokinetics and its relevance in drug development and drug therapy.

Learning Outcomes:
By the end of the unit the student will be able to:
1. Describe the pre-clinical and clinical phases involved in drug development.
2. Explain and contrast the concepts of bioavailability, bioequivalence, generics, and orphan drugs.
3. Explain multiple dose pharmacokinetics and their application to dose regime design. Estimate Cmax, Cmin and Css.
4. Explain rate-limiting processes in pharmacokinetics. Interpret and illustrate flip-flop kinetics and metabolite kinetics.
5. Contrast linear and non-linear pharmacokinetics. Explain the clinical relevance of non-linear pharmacokinetics.
6. Explain distribution kinetics, two compartment models and their clinical relevance.
7. Formulate sources of variability in drug pharmacokinetics: age, disease, food and drug interactions, natural and herbal products.
8. Explain pharmacogenetics and their application to individualized medicine
9. Explain the process of drug therapeutic monitoring and its application in drug therapy.

Skills:
1. Data analysis
2. Problem solving.
3. Analytical thinking
4. Scientific skills
5. Handling information
6. Professional skills
All taught and assessed.

Content:
1. The process of drug development. Pre-clinical and clinical studies. Pharmacovigilance. Generics and bioequivalence. Orphan drugs.
2. Multiple dose pharmacokinetics and design of a dosage regime. IV Bolus and Extravascular. Prediction of Cmax, Cmin and Css.
4. Rate-limiting processes in pharmacokinetics. Flip-flop kinetics. Metabolite kinetics. 5. Non-linear pharmacokinetics. Non-linearity in ADME processes. Michaelis-Menten kinetics. Clinical relevance of non-linear pharmacokinetics.
6. Distribution kinetics. Two compartment models and their clinical relevance.
7. Variability in drug pharmacokinetics: age, disease, food and drug interactions, natural and herbal products.
8. Pharmacogenetics and their application to individualized medicine
9. Drug therapeutic monitoring and its application in drug therapy. Case studies.
Click here for further informationProgramme availability:

PA20294 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology

PA20294 is Compulsory on the following programmes:

Department of Pharmacy & Pharmacology
  • USPA-AFB02 : BSc (hons) Pharmacology (Full-time) - Year 2
  • USPA-AKB02 : BSc (hons) Pharmacology (Full-time with Thick Sandwich Placement) - Year 2
  • USPA-AKM02 : MPharmacology (hons) (Full-time with Thick Sandwich Placement) - Year 2

NB. Programmes and units are subject to change at any time, in accordance with normal University procedures.