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BB20018: Enzymology

Follow this link for further information on academic years Academic Year: 2012/3
Follow this link for further information on owning departmentsOwning Department/School: Department of Biology & Biochemistry
Follow this link for further information on credits Credits: 6
Follow this link for further information on unit levels Level: Intermediate (FHEQ level 5)
Follow this link for further information on period slots Period: Semester 1
Follow this link for further information on unit assessment Assessment: EX 80%, PR 20%
Follow this link for further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Follow this link for further information on unit rules Requisites: Before taking this unit you must take BB10003 and take BB10004
Follow this link for further information on unit content Description: Aims:
To provide a fundamental understanding of enzymes as catalysts, at a physio-chemical level, and to relate these molecular properties to their cellular functions.

Learning Outcomes:
After taking this course the student should be able to:
* describe the relationship between protein structure, ligand binding and enzyme catalysis;
* explain how enzymes achieve their high catalytic rates;
* explain steady-state kinetics of enzyme-catalysed reactions, the nature of reversible inhibition, and the effects of temperature and pH;
* describe and carry out the requirements of reliable enzyme assays;
* explain allosteric regulation in the control of enzymes;
* describe the organisation of cellular enzymes into multienzyme complexes and multifunctional enzymes;
* describe the role of isoenzymes in cellular regulation, development and differentiation, and their application to diagnosis of disease;
* describe and explain the role of coenzymes in enzyme catalysis.

Skills:
Learning and studying T/F/A, Written communication T/F/A, Numeracy & computation T/F/A, Laboratory skills T/F, Information technology T/F, Problem solving T/F, Information handling & retrieval T/F/A, Working independently T/F, Career preparation T/F.

Content:
Ligand binding; steady-state kinetics; inhibition; effects of temperature and pH; principles of enzyme assay; theories of catalysis; allostery; isoenzymes, multienzyme complexes; coenzyme chemistry.
Follow this link for further information on programme availabilityProgramme availability:

BB20018 is Compulsory on the following programmes:

Department of Biology & Biochemistry
  • USBB-AFB02 : BSc (hons) Biochemistry (Full-time) - Year 2
  • USBB-AKB06 : BSc (hons) Biochemistry with Professional Placement (Full-time with Thick Sandwich Placement) - Year 2

BB20018 is Optional on the following programmes:

Department of Biology & Biochemistry
  • USBB-AFB05 : BSc (hons) Molecular and Cellular Biology (Full-time) - Year 2
  • USBB-AKB08 : BSc (hons) Molecular and Cellular Biology with Professional Placement (Full-time with Thick Sandwich Placement) - Year 2
  • RSBB-AFM19 : Integrated PhD Postgenomic Biosciences (Protein Structure & Function Route) (Full-time) - Year 1
  • TSBB-AFM19 : MRes Protein Structure and Function (Full-time) - Year 1
  • TSBB-AFM13 : MSc Protein Structure and Function (Full-time) - Year 1

Notes:
* This unit catalogue is applicable for the 2012/13 academic year only. Students continuing their studies into 2013/14 and beyond should not assume that this unit will be available in future years in the format displayed here for 2012/13.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.