|Owning Department/School:||Department of Chemistry|
|Level:||Masters UG & PG (FHEQ level 7)|
|Supplementary Assessment:||Like-for-like reassessment (where allowed by programme regulations)|
|Requisites:||Before taking this unit you must take CH20149 or take CH20150 and in taking this unit you cannot take CH30068|
|Description:||Aims & Learning Objectives: |
To revise some basic concepts in physical organic chemistry and develop a number of ideas used to correlate reactivity and mechanism in a range of organic reactions. After studying the Unit, students should be able to:
* Describe some experimental tools for investigating reaction mechanisms and the use of some theoretical models for their correlations and interpretation.
* Suggest solutions for complex problems involving combinations of numerical and mechanistic information from a variety of sources.
* Propose appropriate experimental approaches for determination of organic reaction mechanisms.
Energy changes in equilibria and reactivity. Transition states and saddle points. Activation parameters. Analysis of reaction coordinates. Principle of Least Nuclear Motion. Hammond Postulate. More O'Ferrall - Jencks diagrams. Rate - equilibrium correlations. Hammett equation as an example of a linear free-energy relationship. Significance of s and r for reactivity and mechanism. Complex Hammett plots: change in mechanism vs. change in rate-determining step. Equilibrium and kinetic isotope effects. Primary and secondary effects and their significance. Heavy-atom effects. Solvent isotope effects.
CH40068 is Optional on the following programmes:Department of Chemistry