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CH40098: Techniques in drug discovery

[Page last updated: 15 October 2020]

Follow this link for further information on academic years Academic Year: 2020/1
Further information on owning departmentsOwning Department/School: Department of Chemistry
Further information on credits Credits: 3      [equivalent to 6 CATS credits]
Further information on notional study hours Notional Study Hours: 60
Further information on unit levels Level: Masters UG & PG (FHEQ level 7)
Further information on teaching periods Period:
Semester 1
Further information on unit assessment Assessment Summary: CW 100%
Further information on unit assessment Assessment Detail:
  • Coursework (CW 100%)
Further information on supplementary assessment Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this module you must take CH20160
In taking this module you cannot take CH30098
Description: Aims:
To introduce students to some of the specialised technologies and techniques that are used to facilitate the drug discovery process using different case studies to illustrate how drugs are discovered, and understand how they function at a molecular level.

Learning Outcomes:
After taking this course the student should be able to understand:
* Understand how biological targets are identified and understand the many problems associated with the drug discovery process;
* Appreciate the techniques used to sequence, analyse and prepare different types of biomolecule;
* The techniques that scientists employ to generate large numbers of compounds in an automated manner;
* How the techniques of X-ray crystallography and computational modelling are used to determine the structure of complex biomolecules bound to ligands;
* The difficulties associated with preparing large quantities of bioactive molecules on an industrial scale;
* Be familiar with the different techniques used to formulate and administer drug molecules within different therapeutic areas;
* Critically appraise current literature in the area.

Skills:
Numeracy (F, A), Problem solving (T, F A), Scientific writing (F, A), Independent working (F), Group working (F)

Content:
Current problems and bottlenecks associated with the drug-discovery process. Understand the techniques used to purify and analyse biomolecules. Chemical and biochemical techniques used to purify and determine the structures of biomolecules. Techniques used to identify biological targets. Hit to lead optimisation. X-ray crystallography of biomolecules. Computational modelling of biomolecules. Database searching and bioinformatics. Docking drugs into enzyme active sites. Principles of high throughput screening. Combinatorial chemistry. Scavenging resins. Flow chemistry. Microwave chemistry. Principles of scale-up and green chemistry. Process chemistry. Microcalorimetry. Crystal structures and polymorphism. Drug formulation. Administering drugs by oral, intravenous and inhalation routes.
Further information on programme availabilityProgramme availability:

CH40098 is Compulsory on the following programmes:

Department of Chemistry
  • USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 4)
  • USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 4)

CH40098 is Optional on the following programmes:

Programmes in Natural Sciences
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 5)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Professional Placement (Year 5)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 5)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Professional Placement (Year 5)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Professional Placement (Year 5)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Professional Placement (Year 5)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) (Year 4)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Study year abroad (Year 5)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Professional Placement (Year 5)

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