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PA20319: Specialised integrated unit 2: immunity, inflammation & infection

Follow this link for further information on academic years Academic Year: 2020/1
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 12      [equivalent to 24 CATS credits]
Further information on notional study hours Notional Study Hours: 240
Further information on unit levels Level: Intermediate (FHEQ level 5)
Further information on teaching periods Period: Semester 1
Further information on unit assessment Assessment: CW 30%, EX 70%
Further information on supplementary assessment Supplementary Assessment:
Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: While taking this module you must take PA20318 AND take PA20320 AND take PA20321 AND take PA20322
Further information on descriptions Description: Aims:
To provide a comprehensive, integrated understanding of the design and development of medicines, their pharmacological actions in the body and the evidence-based approach to treatment of patients with the aim of promoting safe and effective outcomes in immune disorders, inflammatory disease and infection.

Learning Outcomes:
After successfully completing this unit, the student pharmacist will be able to:
1. Describe the aetiology, epidemiology, pathophysiology and clinical symptoms of immune disorders, inflammatory disorders and infection and how they are diagnosed and treated.
2. Describe the formulation and requirements of parenteral dosage forms and their application in treating infectious diseases
3. Describe the natural host immunological response to infectious agents and explain how inappropriate responses (to non-pathogenic organisms) and failure in self-tolerance can lead to disease.
4. Explain the pharmacology of therapeutic agents used in the treatment of infectious and inflammatory conditions.
5. Classify and identify bacteria, fungi, viruses, protozoa and helminths to enable appropriate selection of antimicrobial treatment and prevention strategies.
6. Discuss effective antimicrobial stewardship through knowledge of antibiotic design, clinical usage and emerging resistance.
7. Explain treatment effectiveness and rationale for disease prevention strategies through the knowledge of antimicrobial lifecycles, pathogenicity and epidemiology
8. Apply knowledge of immunology to describe current processes e.g. vaccinations for disease prevention and eradication and use of biologics as novel therapeutic targets.
9. Identify and utilise the evidence base for treatment of immune disorders, inflammatory disease and infection
10. Describe the role of the pharmacist in prescribing, administering and monitoring medication for patients with immune disorders, inflammatory disease and infection
11. Make appropriate clinical decisions in support of patients with immune disorders, inflammatory disease and infection
12. Apply structured consultation skills to the conditions studied in this unit

Skills:
Scientific and practical skills (T/F/A)
Study skills, handling information, working with others (T/F)
Problem solving (T/F/A)
Study skills (T/F)
Handling information (T/F/A)
Written communication (T/F/A)
Scientific & practical skills (T/F/A)
Information & communication technology (ICT) (T/F)

Content:
Content to include:
Clinical Introduction and overview of therapeutic area - Problem-based learning case
* Pharmaceutics theme
- Protein analysis, diagnostics tests, urinalysis, ELISA, flow cytometry
- Pharmacokinetics of anti-infectives and therapeutic drug monitoring
- Parenteral drug administration
- Formulation and requirements of parenterals
* Pharmacology theme
- Modes of action of antibiotics, antivirals, antifungals and antimalarials
- Immune system - Innate immunity, adaptive immunity, T&B cells, antibodies, immune diseases
* Practical microbiology
* Medicinal Chemistry and drug design theme
- Drug design of antibiotics, antivirals, antifungals, antimalarials, steroids (I)
- New strategic approaches to antibiotic development and deployment
* Clinical therapeutics theme
- Antibiotic resistance and antibiotic stewardship
- Parasitic infestations
- Clinical use of antibacterial, antiviral, antifungal, anti-protozoal drugs
- Vaccines
- Immunosuppression
- The management of acute and chronic inflammation and pain
- Common acute and inflammatory diseases including RA
- Clinical decision-making in the management of infections and inflammatory disease
* Simulation and practice-based learning in immune and infectious diseases.
Further information on programme availabilityProgramme availability:
NB. Postgraduate programme information will be added when the postgraduate catalogues are published in August 2020

PA20319 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
  • USPA-AFM03 : MPharm(Hons) Pharmacy (Year 2)
  • USPA-AKM03 : MPharm(Hons) Pharmacy with integrated pre-registration year (Year 2)

Notes: