Department of Chemical Engineering

Dr Marianne Ellis

Contact details

Room 9 West 3.04

Tel: +44 (0) 1225 384484

Email: M.J.Ellis@bath.ac.uk

Twitter: @MarianneJEllis

Google scholar

PhD supervision

Interested in supervising students studying:

  • Bioreactor design for tissue engineering
  • Stem cell behaviour in bioreactors
  • Transport phenomena in tissue engineering bioreactors

Dr Marianne Ellis

BEng (Hons), PhD, MIChemE

Profile

Dr Marianne Ellis studied for a BEng in Chemical & Bioprocess Engineering and a PhD in Biochemical Engineering at The University of Bath. After a year as a postdoctoral researcher she took up an academic position in 2005. She is an Associate Member of the IChemE, a committee member of the Biochemical Engineering Special Interest Group (BESIG). and a Deputy-Director of the Centre for Regenerative Medicine.

Research

Marianne's research aims to address the challenges of scale-up that are currently being faced in regenerative medicine. The work is focused on upstream bioprocessing for tissue engineering, specifically designing and fabricating bioreactors for large-scale cell culture. She applies the chemical engineering principles of 'unit operations' and the relevant fluid dynamics, mass transfer and reaction kinetics to enable biological advances to be translated into a viable product for use in the clinic.

These principles can be applied to any tissue and Marianne has interest in bone, heart, skin, liver, pancreas and nerve. Examples include the EPSRC-funded project 'Stem cell expansions in a fluidised bed' with focus on seeding stem cells on ceramic particles for bone reconstruction, and the NC3Rs CRACK-IT Challenge grant 'Development and mathematical modelling of zonated hollow fibre bioreactors for in vitro to in vitro extrapolation of systemic chemical toxicity' to design a system that can be used instead of animals for drug screening.

Marianne collaborates with the Bristol Heart Institute; RestoreOxford Centre for Industrial and Applied Mathematics as well as colleagues at the University of Bath in the Departments of Mechanical Engineering, Chemistry and Biology & Biochemistry and other groups in the UK, Europe and the US.

Teaching

  • MEng research project (home)
  • BEng final design project
  • Product design
  • Biomedical engineering
  • MEng final design project
  • Molecular and cellular biochemical engineering

Publications

Read publications by Marianne Ellis