Department of Chemical Engineering

Dr Ram Sharma

Contact details

Room: 9 West 2.09
Tel: +44 (0) 1225 384469
Emailr.sharma@bath.ac.uk

Google Scholar

Dr Ram Sharma

BSc, MSc, PhD

Profile

Dr Ram Sharma completed his doctoral work in Chemical Engineering at Rutgers University, US. He then took up a postdoctoral appointment at ETH Zurich where he was simultaneously the Cell Mechanics Group Leader. He joined the University of Bath as a Lecturer in September 2012.

Research

Ram’s research focuses on cell and tissue engineering. The microenvironment that a cell resides in can maintain or even direct cellular phenotype. Dr Sharma is interested in understanding how the diseased microenvironment that a cell resides in can alter the phenotype of a cell.

The microenvironment of a diseased cell differs to a healthy cell biochemically, structurally, and mechanically. These factors can affect molecular and biophysical properties within the cell that results in an altered cell phenotype, leading to disease progression. Dr Sharma’s research assesses these differences, and examines how providing different cues could revert the pathological phenotype. This research could eventually be applied to developing design and culture strategies for scaffolds and other constructs used in cell and tissue engineering therapies.

Ram’s research is multidisciplinary in nature, fusing together chemical engineering, micro/nanotechnology, cell biology, imaging, and computational sciences.

Publications

Book Sections

Rossi, M., Sharma, R., Pawelski, E. and Moghe, P., 2009. Nanoparticles as biodynamic substrates for engineering cell fate. In: Rege, K. and Medintz, I., eds. Methods in Bioengineering: Nanoscale Bioengineering and Nanomedicine. Boston, MA.: Artech House, pp. 85-106.

Articles

Johns, M., Bernardes, A., Ribeiro De Azevêdo, E., Guimarães, F., Lowe, J., Gale, E., Polikarpov, I., Scott, J. and Sharma, R., 2017. On the subtle tuneability of cellulose hydrogels: implications for binding of biomolecules demonstrated for CBM 1. Journal of Materials Chemistry B, 5 (21), pp. 3879-3887.

Gregory, G. L., Hierons, E. M., Kociok-Kohn, G., Sharma, R. I. and Buchard, A., 2017. CO2-Driven stereochemical inversion of sugars to create thymidine-based polycarbonates by ring-opening polymerisation. Polymer Chemistry, 8 (10), pp. 1714-1721.

Courtenay, J. C., Johns, M. A., Galembeck, F., Deneke, C., Lanzoni, E. M., Costa, C. A., Scott, J. L. and Sharma, R. I., 2017. Surface modified cellulose scaffolds for tissue engineering. Cellulose, 24 (1), pp. 253-267.

Kular, J., Basu, S. and Sharma, R., 2014. The extracellular matrix:Structure, composition, age-related differences, tools for analysis and applications for tissue engineering. Journal of Tissue Engineering, 5, pp. 1-17.

Diederich, V. E. G., Studer, P., Kern, A., Lattuada, M., Storti, G., Sharma, R.I., Snedeker, J.G. and Morbidelli, M., 2013. Bioactive polyacrylamide hydrogels with gradients in mechanical stiffness. Biotechnology and Bioengineering, 110 (5), pp. 1508-1519.

Sharma, R. I. and Snedeker, J. G., 2012. Paracrine interactions between mesenchymal stem cells affect substrate driven differentiation toward tendon and bone phenotypes. PLoS ONE, 7 (2), e31504.

Sharma, R. I., Schwarzbauer, J. E. and Moghe, P. V., 2011. Nanomaterials can dynamically steer cell responses to biological ligands. Small, 7 (2), pp. 242-251.

Bartalena, G., Grieder, R., Sharma, R. I., Zambelli, T., Muff, R. and Snedeker, J. G., 2011. A novel method for assessing adherent single-cell stiffness in tension:Design and testing of a substrate-based live cell functional imaging device. Biomedical Microdevices, 13 (2), pp. 291-301.

Sharma, R. I. and Snedeker, J. G., 2010. Biochemical and biomechanical gradients for directed bone marrow stromal cell differentiation toward tendon and bone. Biomaterials, 31 (30), pp. 7695-7704.

Sharma, R. I., Shreiber, D. I. and Moghe, P. V., 2008. Nanoscale variation of bioadhesive substrates as a tool for engineering of cell matrix assembly. Tissue Engineering Part A, 14 (7), pp. 1237-1250.

Pereira, M., Sharma, R. I., Penkala, R., Gentzel, T. A., Schwarzbauer, J. E. and Moghe, P. V., 2007. Engineered cell-adhesive nanoparticles nucleate extracellular matrix assembly. Tissue Engineering Parts A, B, & C, 13 (3), pp. 567-578.

Sharma, R. I., Pereira, M., Schwarzbauer, J. E. and Moghe, P. V., 2006. Albumin-derived nanocarriers:Substrates for enhanced cell adhesive ligand display and cell motility. Biomaterials, 27 (19), pp. 3589-3598.

Sharma, R. I., Kohn, J. and Moghe, P. V., 2004. Poly(ethylene glycol) enhances cell motility on protein-based poly(ethylene glycol)-polycarbonate substrates:A mechanism for cell-guided ligand remodeling. Journal of Biomedical Materials Research - Part A, 69 (1), pp. 114-123.

Conference or Workshop Items

Coombs OBrien, J., Sharma, R. and Scott, J., 2015. Identification of Natural Materials for Tissue Engineering. In: Enabling Healthcare Technologies: Synthesis, Biomaterials and Sensing, 2015-01-28 - 2015-01-28.

Patent

Mogh, P., Sharma, R. and Pereira-Guelakis, M., 2014. Extracellular matrix production from nanoscale substrate. US 8715718, 06 May 2014.

Moghe, P. V., Sharma, R. and Pereira, M., 2008. Methods, Systems, and Compositions for Extracellular Matrix Production. A61K 8/18, A61Q 13/00, C12P 21/06, 2008.

This list was generated on Mon Oct 16 18:30:38 2017 IST.