Department of Chemistry

jonathan_williams 

Professor of Organic Chemistry

1 South 0.27

Email: J.M.J.Williams@bath.ac.uk

Tel: +44 (0) 1225 383942 

Personal website

 

Prof Jonathan Williams

Profile

Research interests

Research in the Williams group is mainly involved with the use of transition metals for the synthesis of useful organic molecules.  In particular, we have been developing reactions using ‘borrowing hydrogen.’  In this chemistry, ruthenium or iridium catalysts temporarily remove hydrogen to give an aldehyde.  This aldehyde then reacts to give an alkene (or imine) and the hydrogen is then returned to give a C-C or C-N bond.  These procedures allow alcohols to be used as alkylating agents in place of more conventional, but often toxic/mutagenic alkyl halides.

Individual Areas

  • Irreversible hydrogen transfer reactions
  • Deracemisation of secondary alcohols
  • C-N Bond formation from alcohols
  • C-C Bond formation from alcohols
  • Heterocycle synthesis
  • Amides and nitriles from oximes

Publications

Marcé, P., Lynch, J., Blacker, A. J. and Williams, J. M. J., 2016. A mild hydration of nitriles catalysed by copper(ii) acetate. Chemical Communications, 52 (7), pp. 1436-1438.

Abou-Shehada, S., Teasdale, M. C., Bull, S. D., Wade, C. E. and Williams, J. M. J., 2015. Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition. ChemSusChem, 8 (6), pp. 1083-1087.

Walton, J. W. and Williams, J. M. J., 2015. Catalytic SNAr of unactivated aryl chlorides. Chemical Communications, 51 (14), pp. 2786-2789.

Atkinson, B. N. and Williams, J. M. J., 2014. Scandium triflate catalyzed ester synthesis using primary amides. Tetrahedron Letters, 55 (50), pp. 6935-6938.

Atkinson, B. and Williams, J. M. J., 2014. Dimethylsulfoxide as an N-Methylation Reagent for Amines and Aromatic Nitro Compounds. ChemCatChem, 6 (7), pp. 1860-1862.

Abou-Shehada, S. and Williams, J. M. J., 2014. Separated tandem catalysis:It's about time! Nature Chemistry, 6 (1), pp. 12-13.

Van Der Waals, D., Pettman, A. and Williams, J. M. J., 2014. Copper-catalysed reductive amination of nitriles and organic-group reductions using dimethylamine borane. RSC Advances, 4 (94), pp. 51845-51849.

Ma, W. M. J., James, T. D. and Williams, J. M. J., 2013. Synthesis of amines with pendant boronic esters by borrowing hydrogen catalysis. Organic Letters, 15 (18), pp. 4850-4853.

Williams, J. M. J., 2013. OH activation for nucleophilic substitution. In: Dunn, P. J., Hii, K. K., Krische, M. J. and Williams, M. T., eds. Sustainable Catalysis. Hoboken, New Jersey: Wiley, pp. 121-137.

Watson, A.J.A., Atkinson, B.N., Maxwell, A.C. and Williams, J. M. J., 2013. Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds. Advanced Synthesis & Catalysis, 355 (4), pp. 734-740.

Davulcu, S., Allen, C.L., Milne, K. and Williams, J. M. J., 2013. Catalytic conversion of nitriles into secondary- and tertiary amides. ChemCatChem, 5 (2), pp. 435-438.

Wakeham, R.J., Taylor, J.E., Bull, S.D., Morris, J.A. and Williams, J. M. J., 2013. Iodide as an activating agent for acid chlorides in acylation reactions. Organic Letters, 15 (3), pp. 702-705.

Sharma, S.K., Lynch, J., Sobolewska, A.M., Plucinski, P., Watson, R.J. and Williams, J. M. J., 2013. Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor. Catalysis Science and Technology, 3 (1), pp. 85-88.

Atkinson, B. N., Chhatwal, A. R., Lomax, H. V., Walton, J. W. and Williams, J. M. J., 2012. Transamidation of primary amides with amines catalyzed by zirconocene dichloride. Chemical Communications, 48 (95), pp. 11626-11628.

Walton, J.W. and Williams, J. M. J., 2012. Ruthenium-catalyzed ortho-alkylation of phenols with alcohols by dehydrative coupling. Angewandte Chemie-International Edition, 51 (49), pp. 12166-12168.

Allen, C. L., Atkinson, B. N. and Williams, J. M. J., 2012. Transamidation of primary amides with amines using hydroxylamine hydrochloride as an inorganic catalyst. Angewandte Chemie-International Edition, 51 (6), pp. 1383-1386.

Watson, A. J. A., Maxwell, A. C. and Williams, J. M. J., 2012. Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols. Organic and Biomolecular Chemistry, 10 (2), pp. 240-243.

Taylor, J. E., Bull, S. D. and Williams, J. M. J., 2012. Amidines, isothioureas, and guanidines as nucleophilic catalysts. Chemical Society Reviews, 41 (6), pp. 2109-2121.

Kolaczkowski, S. and Williams, J., 2012. Continuous Flow Solutions for Pharmaceutical Manufacture. University of Bath.

Allen, C. L., Chhatwal, A. R. and Williams, J. M. J., 2012. Direct amide formation from unactivated carboxylic acids and amines. Chemical Communications, 48 (5), pp. 666-668.

Fan, X., Sans, V., Yaseneva, P., Plaza, D. D., Williams, J. and Lapkin, A., 2012. Facile stoichiometric reductions in flow: An example of artemisinin. Organic Process Research and Development, 16 (5), pp. 1039-1042.

Taylor, J. E., Jones, M. D., Williams, J. M. J. and Bull, S. D., 2012. N -acyl DBN tetraphenylborate salts as N -acylating agents. Journal of Organic Chemistry, 77 (6), pp. 2808-2818.

Taylor, J. E., Williams, J. M. J. and Bull, S.D., 2012. N-acyl 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) tetraphenylborate salts as O-acylating agents. Tetrahedron Letters, 53 (32), pp. 4074-4076.

Nixon, T. D., Whittlesey, M. K. and Williams, J. M. J., 2011. Ruthenium-catalysed transfer hydrogenation reactions with dimethylamine borane. Tetrahedron Letters, 52 (49), pp. 6652-6654.

Allen, C. L., Lawrence, R., Emmett, L. and Williams, J. M. J., 2011. Mechanistic studies into metal-catalyzed aldoxime to amide rearrangements. Advanced Synthesis & Catalysis, 353 (18), pp. 3262-3268.

Sharma, S. K., Bishopp, S. D., Allen, C. L., Lawrence, R., Bamford, M. J., Lapkin, A. A., Plucinski, P., Watson, R. J. and Williams, J. M. J., 2011. Copper-catalyzed rearrangement of oximes into primary amides. Tetrahedron Letters, 52 (33), pp. 4252-4255.

Ledger, A. E. W., Ellul, C. E., Mahon, M. F., Williams, J. M. J. and Whittlesey, M. K., 2011. Ruthenium bidentate phosphine complexes for the coordination and catalytic dehydrogenation of amine- and phosphine-boranes. Chemistry - A European Journal, 17 (31), pp. 8704-8713.

Watson, A. J. A., Maxwell, A. C. and Williams, J. M. J., 2011. Borrowing hydrogen methodology for amine synthesis under solvent-free microwave conditions. Journal of Organic Chemistry, 76 (7), pp. 2328-2331.

Saidi, O. and Williams, J. M. J., 2011. Iridium-Catalyzed Hydrogen Transfer Reactions. In: Iridium Catalysis. Berlin: Springer, pp. 77-106.

Allen, C. L. and Williams, J. M. J., 2011. Metal-catalysed approaches to amide bond formation. Chemical Society Reviews, 40 (7), pp. 3405-3415.

Taylor, J. E., Jones, M., Williams, J. M. J. and Bull, S. D., 2010. Friedel-Crafts acylation of pyrroles and indoles using 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) as a nucleophilic catalyst. Organic Letters, 12 (24), pp. 5740-5743.

Lamb, G. W., Al Badran, F. A., Williams, J. M. J. and Kolaczkowski, S. T., 2010. Production of pharmaceuticals: amines from alcohols in a continuous flow fixed bed catalytic reactor. Chemical Engineering Research & Design, 88 (12), pp. 1533-1540.

Saidi, O., Bamford, M. J., Blacker, A. J., Lynch, J., Marsden, S. P., Plucinski, P., Watson, R. J. and Williams, J. M. J., 2010. Iridium-catalyzed formylation of amines with paraformaldehyde. Tetrahedron Letters, 51 (44), pp. 5804-5806.

Ledger, A. E. W., Moreno, A., Ellul, C. E., Mahon, M. F., Pregosin, P. S., Whittlesey, M. K. and Williams, J. M. J., 2010. Pincer Phosphine Complexes of Ruthenium: Formation of Ru(P-O-P)(PPh3)HCl (P-O-P = xantphos, DPEphos, (Ph2PCH2CH2)(2)O) and Ru(dppf)(PPh3)HCl and Characterization of Cationic Dioxygen, Dihydrogen, Dinitrogen, and Arene Coordinated Phosphine Products. Inorganic Chemistry, 49 (16), pp. 7244-7256.

Watson, A. J. A. and Williams, J. M. J., 2010. The give and take of alcohol activation. Science, 329 (5992), pp. 635-636.

Watson, A. J. A., Maxwell, A. C. and Williams, J. M. J., 2010. Ruthenium-catalyzed aromatic C-H activation of benzylic alcohols via remote electronic activation. Organic Letters, 12 (17), pp. 3856-3859.

Saidi, O., Blacker, A. J., Lamb, G. W., Marsden, S. P., Taylor, J. E. and Williams, J. M. J., 2010. Borrowing hydrogen in water and ionic liquids: iridium-catalyzed alkylation of amines with alcohols. Organic Process Research & Development, 14 (4), pp. 1046-1049.

Bahn, S., Imm, S., Mevius, K., Neubert, L., Tillack, A., Williams, J. M. J. and Beller, M., 2010. Selective ruthenium-catalyzed N-alkylation of indoles by using alcohols. Chemistry - A European Journal, 16 (12), pp. 3590-3593.

Saidi, O., Blacker, A. J., Farah, M. M., Marsden, S. P. and Williams, J. M. J., 2010. Iridium-catalysed amine alkylation with alcohols in water. Chemical Communications, 46 (9), pp. 1541-1543.

Maytum, H. C., Francos, J., Whatrup, D. J. and Williams, J. M. J., 2010. 1,4-Butanediol as a reducing agent in transfer hydrogenation reactions. Chemistry - An Asian Journal, 5 (3), pp. 538-542.

Allen, C. L., Davulcu, S. and Williams, J., 2010. Catalytic acylation of amines with aldehydes or aldoximes. Organic Letters, 12 (22), pp. 5096-5099.

Allen, C. L., Burel, C. and Williams, J. M. J., 2010. Cost efficient synthesis of amides from oximes with indium or zinc catalysts. Tetrahedron Letters, 51 (20), pp. 2724-2726.

Allen, C. L. and Williams, J. M. J., 2010. Ruthenium-catalyzed alkene synthesis by the decarbonylative coupling of aldehydes with alkynes. Angewandte Chemie-International Edition, 49 (10), pp. 1724-1725.

Saidi, O., Blacker, A. J., Farah, M. M., Marsden, S. P. and Williams, J. M. J., 2009. Selective amine cross-coupling using iridium-catalyzed "borrowing hydrogen" methodology. Angewandte Chemie-International Edition, 48 (40), pp. 7375-7378.

Allen, C. L., Lapkin, A. A. and Williams, J. M. J., 2009. An iron-catalysed synthesis of amides from nitriles and amines. Tetrahedron Letters, 50 (29), pp. 4262-4264.

Watson, A. J. A., Maxwell, A. C. and Williams, J. M. J., 2009. Ruthenium-catalyzed oxidation of alcohols into amides. Organic Letters, 11 (12), pp. 2667-2670.

Blacker, A. J., Farah, M. M., Hall, M. I., Marsden, S. P., Saidi, O. and Williams, J. M. J., 2009. Synthesis of Benzazoles by Hydrogen-Transfer Catalysis. Organic Letters, 11 (9), pp. 2039-2042.

Owston, N. A., Nixon, T. D., Parker, A. J., Whittlesey, M. K. and Williams, J. M., 2009. Conversion of Primary Alcohols and Aldehydes into Methyl Esters by Ruthenium-Catalysed Hydrogen Transfer Reactions. Synthesis, 9, pp. 1578-1581.

Hamid, M. H. S. A., Allen, C. L., Lamb, G. W., Maxwell, A. C., Maytum, H. C., Watson, A. J. A. and Williams, J. M. J., 2009. Ruthenium-catalyzed N-alkylation of amines and sulfonamides using borrowing hydrogen methodology. Journal of the American Chemical Society, 131 (5), pp. 1766-1774.

Lamb, G. W., Watson, A. J. A., Jolley, K. E., Maxwell, A. C. and Williams, J. M., 2009. Borrowing hydrogen methodology for the conversion of alcohols into N-protected primary amines and in situ deprotection. Tetrahedron Letters, 50 (26), pp. 3374-3377.

Blacker, A. J., Farah, M. M., Marsden, S. P., Saidi, O. and Williams, J. M. J., 2009. Oxidative conversion of amines into benzoxazoles using hydrogen transfer catalysis. Tetrahedron Letters, 50 (45), pp. 6106-6109.

Ledger, A. E. W., Slatford, P. A., Lowe, J. P., Mahon, M. F., Whittlesey, M. K. and Williams, J. M. J., 2009. Ruthenium xantphos complexes in hydrogen transfer processes: reactivity and mechanistic studies. Dalton Transactions, 4, pp. 716-722.

Pridmore, S. J., Slatford, P. A., Taylor, J. E., Whittlesey, M. K. and Williams, J. M. J., 2009. Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation. Tetrahedron, 65 (44), pp. 8981-8986.

Nixon, T. D., Whittlesey, M. K. and Williams, J. M. J., 2009. Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology. Dalton Transactions, 5, pp. 753-762.

Lamb, G. W. and Williams, J. M. J., 2008. Borrowing hydrogen - C - N bond formation from alcohols. Chimica Oggi-Chemistry Today, 26 May-Jun (3), pp. 17-19.

Pridmore, S. J. and Williams, J. M. J., 2008. C-C bond formation from alcohols and malonate half esters using borrowing hydrogen methodology. Tetrahedron Letters, 49 (52), pp. 7413-7415.

Owston, N. A., Parker, A. J. and Williams, J. M. J., 2008. Oxidation of primary alcohols to methyl esters by hydrogen transfer. Chemical Communications

This list was generated on Tue May 31 11:22:26 2016 IST.

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