Department of Chemistry

Stephen Flower

Teaching Fellow
Director of Studies – Natural Sciences: Year 3 & 4, MSc Chemistry for Drug Discovery, MRes Chemistry

3 South 1.02

Email: s.e.flower@bath.ac.uk

Tel: +44 (0)1225 384881

Personal page

 

Dr Stephen Flower

Profile

I'm Director of Studies for the MSc in Chemistry for Drug Discovery and MRes in Chemistry programmes and teach Organic Chemistry and Drug Discovery. My Postdoctoral research focussed on the synthesis of fluorescent and electrochemical sensors for biomedical applications with industrial partners for uses such DNA detection and blood sugar level monitoring and this has shaped my interests in the application of synthetic organic chemistry to healthcare challenges.

I'm active in Widening Participation and Outreach activities, the Salters' Festivals of Chemistry and the Goldsmiths Company's "Sustainable Energy Residential Course" for teachers.

Research Interests

My current research interests are in the areas of novel anti-MRSA drugs and targetted anti-cancer drugs that utilise reversible cyclisation to become activated in the tumor cell. My other area of interest is in the development of new tunable fluorophores with orthogonal sites of attachment to biological targets.

Publications

Flower, Stephen, 2016. Materials and methods for analysing glycation. G01 N27/447(200.01)- US 2016/282355 A1, 2016.

Sun, X., Lacina, K., Ramsamy, E. C., Flower, S. E., Fossey, J. S., Qian, X., Anslyn, E. V., Bull, S. D. and James, T. D., 2015. Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite. Chemical Science, 6 (5), pp. 2963-2967.

Lawrence, K., Xia, F., Arrowsmith, R. L., Ge, H., Nelson, G. W., Foord, J. S., Felipe-Sotelo, M., Evans, N. D. M., Mitchels, J. M., Flower, S. E., Botchway, S. W., Wolverson, D., Aliev, G., James, T. D., Pascu, S. I. and Marken, F., 2014. Hydrothermal conversion of one-photon-fluorescent poly-(4-vinylpyridine) into two-photon-fluorescent carbon nanodots. Langmuir, 30 (39), 11746–11752.

Sun, X., Xu, Q., Kim, G., Flower, S.E., Lowe, J., Yoon, J., Fossey, J.S., Qian, X., Bull, S.D. and James, T.D., 2014. A water-soluble boronate-based fluorescent probe for the selective detection of peroxynitrite and imaging in living cells. Chemical Science, 5 (9), pp. 3368-3373.

Regan, E. M., Flower, S. E., Wang, H.-C., Fossey, J. S., James, T. D. and Estrela, P., 2014. An enzyme-less bis-boronic acid modified electrode for glucose sensing in human blood serum. In: 24th Anniversary World Congress on Biosensors, 2014-05-27 - 2014-05-30.

Xu, S.-Y., Wang, H.-C., Flower, S. E., Fossey, J. S., Jiang, Y.-B. and James, T. D., 2014. Suzuki homo-coupling reaction based fluorescent sensors for monosaccharides. RSC Advances, 4 (66), pp. 35238-35241.

Xu, S., Hu, B., Flower, S. E., Jiang, Y.-B., Fossey, J. S., Deng, W.-P. and James, T. D., 2013. Colorimetric enantioselective recognition of chiral secondary alcohols via hydrogen bonding to a chiral metallocene containing chemosensor. Chemical Communications, 49 (75), pp. 8314-8316.

Sun, X., Xu, S., Flower, S. E., Fossey, J. S., Qian, X. and James, T. D., 2013. “Integrated” and “insulated” boronate-based fluorescent probes for the detection of hydrogen peroxide. Chemical Communications, 49 (75), pp. 8311-8313.

Pereira Morais, M. P., Marshall, D., Flower, S. E., Caunt, C. J., James, T. D., Williams, R. J., Waterfield, N. R. and Van Den Elsen, J. M. H., 2013. Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis. Scientific Reports, 3, 1437.

Flower, Stephen, 2012. Novel Ferrocene Labels For Electrochemical Assay and Their Use in Analytical Methods. C07F 17/02(2006.01)- WO 2012/085591 A1, 28 June 2012.

Lawrence, K., Flower, S.E., Kociok-Kohn, G., Frost, C.G. and James, T.D., 2012. A simple and effective colorimetric technique for the detection of boronic acids and their derivatives. Analytical Methods, 4 (8), pp. 2215-2217.

D'Hooge, F., Elfeky, S. A., Flower, S., Pascu, S. I., Jenkins, A. T. A., van den Elsen, J., James, T. and Fossey, J., 2012. Biotinylated boronic acid fluorophore conjugates: quencher elimination strategy for imaging and saccharide detection. RSC Advances, 2, pp. 3274-3280.

Schuller, T. A., Kuball, M., Flower, S. E., James, T. D., Fossey, J. S., Marcon, D., Das, J., Degroot, S., Germain, M. and Sarua, A., 2011. Field-effect saccharide sensing using AlGaN/GaN heterostructures and boronic acid based chemical receptors. Sensors and Actuators B-Chemical, 160 (1), pp. 1078-1081.

Flower, Stephen, 2010. Protease detection assay. C07F15/00- 20100320093, 23 December 2010.

Rassaei, L., Jaber, R., Flower, S. E., Edler, K. J., Compton, R. G., James, T. D. and Marken, F., 2010. Microwave-electrochemical formation of colloidal zinc oxide at fluorine doped tin oxide electrodes. Electrochimica Acta, 55 (27), pp. 7909-7915.

Elfeky, S. A., Flower, S. E., Masumoto, N., D'Hooge, F., Labarthe, L., Chen, W. B., Len, C., James, T. D. and Fossey, J. S., 2010. Diol appended quenchers for fluorescein boronic acid. Chemistry - An Asian Journal, 5 (3), pp. 581-588.

Larkin, J. D., Frimat, K. A., Fyles, T. M., Flower, S. E. and James, T. D., 2010. Boronic acid based photoinduced electron transfer (PET) fluorescence sensors for saccharides. New Journal of Chemistry, 34 (12), pp. 2922-2931.

This list was generated on Tue Oct 17 11:04:17 2017 IST.

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