Department of Chemistry



1 South 0.12


Tel: +44 (0) 1225 386118 

Personal website


Professor Toby Jenkins


Research in the group is focussed on four main areas:

1. Development and testing of new materials for clinical and biological applications. As part of a European Commission funded 7th Framework programme we are developing innovative anti-microbial coatings. To be applied to medical devices such as catheters, wound dressings and personal care items, these are based on novel organo-silver, organo-copper and organo-zinc complexes, developed by the group in collaboration with Dr Andrew Johnson’s group.

2. Study of biomimetic lipid membrane - bacterial toxin interaction. Using solid supported lipid bilayer vesicles with encapsulated dye, in the study of how bacterial toxins, such as cholera and α-haemolysin interact with cell membranes. By combining Surface Plasmon Resonance (SPR) and SPR enhanced Fluorescence, observations of both toxin binding to lipid bilayer membranes and any resultant permeabilisation are made.

3. Sensors for clinical microbiology. With Atlas Genetics, a University of Bath spin-out company, we have developed a Point-of-Care test for the fast diagnosis of infection for various microbial pathogens, including Streptococcus pyrogenes, Candida albicans and Neisseria meningitidis. The test utilises an on-chip PCR amplification of target gene sequences and coupled electrochemical detection.

4. Advanced wound dressings. A newly emerging area of research, in collaboration with clinicians and paediatricians at the Paediatrics Burns Unit for the South West of England at Frenchay Hospital, Bristol.


Gomes-Fernandes, M., Laabei, M., Pagan, N., Hidalgo, J., Molinos, S., Villar Hernandez, R., Domínguez-Villanueva, D., Jenkins, A. T. A., Lacoma, A. and Prat, C., 2017. Accessory gene regulator (Agr) functionality in Staphylococcus aureus derived from lower respiratory tract infections. PLoS ONE, 12 (4), e0175552.

Hathaway, H., Ajuebor, J., Stephens, L., Coffey, A., Potter, U., Sutton, J. M. and Jenkins, A. T. A., 2017. Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA). Journal of Controlled Release, 245, pp. 108-115.

Thet, Naing, 2016. Wound dressing. US- US9499852 B2, 22 November 2016.

Milo, S., Thet, N. T., Liu, D., Nzakizwanayo, J., Jones, B. V. and Jenkins, A. T. A., 2016. An in-situ infection detection sensor coating for urinary catheters. Biosensors and Bioelectronics, 81, pp. 166-172.

Thet, N., Jenkins, A., Bean, J. and Alves, D., 2016. Intelligent Wound Dressing for Therapeutic and Diagnostic Management of Wound Infection. In: 5th Global Healthcare Conference, 2016-07-18 - 2016-07-19, Hotel Fort Canning. Singapore: Global Science & Technology Forum.

Thet, N. T., Alves, D. R., Bean, J. E., Booth, S., Nzakizwanayo, J., Young, A. E. R., Jones, B. V. and Jenkins, A. T. A., 2016. Prototype development of the intelligent hydrogel wound dressing and its efficacy in the detection of model pathogenic wound biofilms. ACS Applied Materials and Interfaces, 8 (24), pp. 14909-14919.

Nzakizwanayo, J., Hanin, A., Alves, D. R., McCutcheon, B., Dedi, C., Salvage, J., Knox, K., Stewart, B., Metcalfe, A., Clark, J., Gilmore, B. F., Gahan, C. G. M., Jenkins, A. T. A. and Jones, B. V., 2016. Bacteriophage can prevent encrustation and blockage of urinary catheters by Proteus mirabilis. Antimicrobial Agents and Chemotherapy, 60 (3), pp. 1530-1536.

Perez Esteban, P., Jenkins, A. T. A. and Arnot, T. C., 2016. Elucidation of the mechanisms of action of Bacteriophage K / nano-emulsion formulations against S. aureus via measurement of particle size and zeta potential. Colloids and Surfaces B: Biointerfaces, 139, pp. 87-94.

Alves, D., Pérez Esteban, P., Kot, W., Bean, J., Arnot, T., Hansen, L., Enright, M. and Jenkins, A., 2016. A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions. Microbial Biotechnology, 9 (1), pp. 61-74.

Ebrahimi, M.-M. S., Laabei, M., Jenkins, A. T. A. and Schönherr, H., 2015. Autonomously sensing hydrogels for the rapid and selective detection of pathogenic bacteria. Macromolecular Rapid Communications, 36 (24), pp. 2123-2128.

Williams, T. L., Urbanc, B., Marshall, K. E., Vadukul, D. M., Jenkins, A. T. A. and Serpell, L. C., 2015. Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation. FEBS Letters, 589 (21), pp. 3228-3236.

Hathaway, H., Alves, D. R., Bean, J., Perez Esteban, P., Ouadi, K., Mark Sutton, J. and Jenkins, A. T. A., 2015. Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K. European Journal of Pharmaceutics and Biopharmaceutics, 96, pp. 437-441.

Thet, N. T. and Jenkins, A. T. A., 2015. An electrochemical sensor concept for the detection of virulence factors from Staphylococcus aureus and Pseudomonas aeruginosa. Electrochemistry Communications, 59, pp. 104-108.

Beeton, M., Alves, D., Enright, M. and Jenkins, A., 2015. Assessing phage therapy against Pseudomonas aeruginosa using a Galleria mellonella infection model. International Journal of Antimicrobial Agents, 46 (2), pp. 196-200.

Hathaway, H. J., Sutton, J. M. and Jenkins, A. T. A., 2015. Study into the kinetic properties and surface attachment of a thermostable adenylate kinase. Biochemistry and Biophysics Reports, 1, pp. 1-7.

Bean, J. E., Alves, D. R., Laabei, M., Pérez Esteban, P., Thet, N. T., Enright, M. C. and Jenkins, A. T. A., 2014. Triggered Release of Bacteriophage K from Agarose/Hyaluronan Hydrogel Matrixes by Staphylococcus aureus Virulence Factors. Chemistry of Materials, 26 (24), pp. 7201-7208.

Laabei, M., Jamieson, W. D., Yang, Y., Van Den Elsen, J. and Jenkins, A. T. A., 2014. Investigating the lytic activity and structural properties of Staphylococcus aureus phenol soluble modulin (PSM) peptide toxins. Biochimica Et Biophysica Acta-Biomembranes, 1838 (12), pp. 3153-3161.

Mahe, L. S. A., Green, S. J., Winlove, C. P. and Jenkins, A. T. A., 2014. Pyrene-wired antibodies on highly oriented pyrolytic graphite as a label-free impedance biosensor for the sepsis biomarker procalcitonin. Journal of Solid State Electrochemistry, 18 (12), pp. 3245-3249.

Alves, D., Gaudion, A., Bean, J., Pérez Esteban, P., Arnot, T. C., Harper, D. R., Kot, W., Hansen, L. H., Enright, M. C. and Jenkins, A. T. A., 2014. Combined use of bacteriophage K and a novel bacteriophage to reduce Staphylococcus aureus biofilm. Applied and Environmental Microbiology, 80 (21), pp. 6694-6703.

Pérez Esteban, P., Enright, M. C., Jenkins, T. and Arnot, T., 2014. Effect of nano-emulsions and bacteriophage/nano-emulsion formulations on S. aureus and P. aeruginosa growth patterns in biofilms. In: Phages 2014, 2014-09-16 - 2014-09-18.

Hong, S.-H., Szili, E. J., Jenkins, A. T. A. and Short, R. D., 2014. Ionized gas (plasma) delivery of reactive oxygen species (ROS) into artificial cells. Journal of Physics D: Applied Physics, 47 (36), 362001.

Laabei, M., Jamieson, W. D., Lewis, S. E., Diggle, S. P. and Jenkins, A. T. A., 2014. A new assay for rhamnolipid detection-important virulence factors of Pseudomonas aeruginosa. Applied Microbiology and Biotechnology, 98 (16), pp. 7199-7209.

Pérez Esteban, P., Alves, D., Enright, M. C., Bean, J. E., Gaudion, A., Jenkins, A. T. A., Young, A. E. R. and Arnot, T. C., 2014. Enhancement of the antimicrobial properties of bacteriophage-K via stabilisation using oil-in-water nano-emulsions. Biotechnology Progress, 30 (4), pp. 932-944.

Thet, N.T., Jamieson, W.D., Laabei, M., Mercer-Chalmers, J.D. and Jenkins, A.T.A., 2014. Photopolymerization of polydiacetylene in hybrid liposomes:Effect of polymerization on stability and response to pathogenic bacterial toxins. Journal of Physical Chemistry B, 118 (20), pp. 5418-5427.

Malzahn, K., Jamieson, W. D., Dröge, M., Mailänder, V., Jenkins, A. T. A., Weiss, C. K. and Landfester, K., 2014. Advanced dextran based nanogels for fighting Staphylococcus aureus infections by sustained zinc release. Journal of Materials Chemistry C, 2 (15), pp. 2175-2183.

Mulley, G., Jenkins, A.T.A. and Waterfield, N.R., 2014. Inactivation of the antibacterial and cytotoxic properties of silver ions by biologically relevant compounds. PLoS ONE, 9 (4).

Laabei, M., Jamieson, W. D., Massey, R. C. and Jenkins, A. T. A., 2014. Staphylococcus aureus Interaction with Phospholipid Vesicles – A New Method to Accurately Determine Accessory Gene Regulator (agr) Activity. PLoS ONE, 9 (1), e87270.

Perez Esteban, P., Alves, D., Enright, M., Jenkins, A. and Arnot, T., 2014. Investigation of the relative effects of Nano-emulsion and Bacteriophage / Nano-emulsion formulations on S. aureus and P. aeruginosa growth patterns in biofilms. In: Viruses of Microbes 2014: Structure and function, from molecules to communities, 2014-07-14 - 2014-07-18, Zurich.

Perez Esteban, P., Jenkins, A. and Arnot, T., 2014. STABILISATION OF BACTERIOPHAGE-K IN OIL-IN-WATER NANO-EMULSIONS FOR THE TREATMENT OF BURN WOUND INFECTIONS. In: Exploiting Bacteriophages for Bioscience, Biotechnology and Medicine 2014, 2014-01-24 - 2014-01-24.

Feng, C.-L., Dou, X.-Q., Liu, Q.-L., Zhang, W., Gu, J.-J., Zhu, S.-M., Jenkins, A. T. A. and Zhang, D., 2013. Dual-specific interaction to detect DNA on gold nanoparticles. Sensors, 13 (5), pp. 5749-5756.

Thet, Naing, 2013. Wound dressing. WO2013104876 A1, 18 July 2013.

Marshall, S.E., Hong, S.-H., Thet, N.T. and Jenkins, A.T.A., 2013. Effect of lipid and fatty acid composition of phospholipid vesicles on long-term stability and their response to Staphylococcus aureus and Pseudomonas aeruginosa supernatants. Langmuir, 29 (23), pp. 6989-6995.

Marshall, S., Jenkins, A. T. A., Al-Bataineh, S. A., Short, R. D., Hong, S.-H., Thet, N. T., Oh, J.-S., Bradley, J. W. and Stili, E. J., 2013. Studying the cytolytic activity of gas plasma with self-signalling phospholipid vesicles dispersed within a gelatin matrix. Journal of Physics D: Applied Physics, 46 (18), 185401.

Thet, N.T., Hong, S.H., Marshall, S., Laabei, M. and Jenkins, A. T. A., 2013. Visible, colorimetric dissemination between pathogenic strains of Staphylococcus aureus and Pseudomonas aeruginosa using fluorescent dye containing lipid vesicles. Biosensors and Bioelectronics, 41 (1), pp. 538-543.

Bull, S.D., Davidson, M.G., Van Den Elsen, J.M.H., Fossey, J.S., Jenkins, A.T.A., Jiang, Y.-B., Kubo, Y., Marken, F., Sakurai, K., Zhao, J. and James, T.D., 2013. Exploiting the reversible covalent bonding of boronic acids:Recognition, sensing, and assembly. Accounts of Chemical Research, 46 (2), pp. 312-326.

Perez Esteban, P., Jenkins, A. and Arnot, T., 2013. Enhancement of the Antimicrobial Properties of Bacteriophage K via Stabilisation in Oil-in-Water Nano-emulsions. In: Phages 2013, 2013-09-10 - 2013-09-12.

Perez Esteban, P., Jenkins, A. and Arnot, T., 2013. Stabilisation of Bacteriophage K in oil-in-water nano- emulsions for the treatment of burn wound infections. In: European Congress of Chemical Engineering/European Congress of Applied Biotechnology (ECCE9/ECAB2), 2013-04-21 - 2013-04-25.

Perez Esteban, P., Jenkins, A. and Arnot, T., 2013. Stabilisation of Bacteriophage K in oil-in-water nano- emulsions for the treatment of burn wound infections. In: ChemEngDayUK 2013, 2013-03-25 - 2013-03-26.

Fossey, J.S., D'Hooge, F., van den Elsen, J.M.H., Pereira Morais, M.P., Pascu, S.I., Bull, S.D., Marken, F., Jenkins, A.T.A., Jiang, Y.-B. and James, T.D., 2012. The development of boronic acids as sensors and separation tools. Chemical Record, 12 (5), pp. 464-478.

Laabei, M., Young, A. and Jenkins, A. T. A., 2012. In vitro studies of toxic shock toxin-1-secreting staphylococcus aureus and implications for burn care in children. Pediatric Infectious Disease Journal, 31 (5), e73-e77.

Jenkins, T., 2012. Anti-microbial burn dressing fights bacterial infection: University of Bath research. University of Bath.

D'Hooge, F., Elfeky, S. A., Flower, S., Pascu, S. I., Jenkins, A. T. A., van den Elsen, J., James, T. and Fossey, J., 2012. Biotinylated boronic acid fluorophore conjugates: quencher elimination strategy for imaging and saccharide detection. RSC Advances, 2, pp. 3274-3280.

Jenkins, T., 2012. Novel Responsive Antimicrobial Dressing. University of Bath.

James, C., Johnson, A. L. and Jenkins, A. T. A., 2011. Antimicrobial surface grafted thermally responsive PNIPAM-co-ALA nano-gels. Chemical Communications, 47 (48), pp. 12777-12779.

Zhou, J., Tun, T. N., Hong, S.-H., Mercer-Chalmers, J. D., Laabei, M., Young, A. E. R. and Jenkins, A. T. A., 2011. Development of a prototype wound dressing technology which can detect and report colonization by pathogenic bacteria. Biosensors and Bioelectronics, 30 (1), pp. 67-72.

Gilbert, L., Jenkins, A. T. A., Browning, S. and Hart, J. P., 2011. Development of an amperometric, screen-printed, single-enzyme phosphate ion biosensor and its application to the analysis of biomedical and environmental samples. Sensors and Actuators B-Chemical, 160 (1), pp. 1322-1327.

Johnson, Andrew, 2011. Antimicrobial coatings. C09D5/14- EP2389419(A1), 03 November 2011.

Tun, T. N., Cameron, P. J. and Jenkins, A. T. A., 2011. Sensing of pathogenic bacteria based on their interaction with supported bilayer membranes studied by impedance spectroscopy and surface plasmon resonance. Biosensors and Bioelectronics, 28 (1), pp. 227-231.

Williams, T. L., Johnson, B. R. G., Urbanc, B., Jenkins, A. T. A., Connell, S. D. A. and Serpell, L. C., 2011. Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes. Biochemical Journal, 439 (1), pp. 67-77.

Jenkins, A. T. A., Thet, N. T., Zhou, J., Hong, S. H. and Marshall, S., 2011. A microbiologically sensitive “intelligent” burns dressing concept. Burns, 37 (Supplement 1), S5.

Foerch, Renate, 2011. Active antimicrobial compositions, coatings and methods for controlling pathogenic bacteria. A01N25/28- EP2361502(A1), 31 August 2011.

James, C., Pugh, T., Johnson, A. L. and Jenkins, A. T. A., 2011. An antimicrobial zinc based molecule for cross linking poly-acrylic acid. European Polymer Journal, 47 (6), pp. 1338-1345.

Perez Esteban, P., Jenkins, A., Enright, M. and Arnot, T., 2011. Development of Responsive Wound Dressings for Treatment of Burns and Wound Site Infections. In: 11th UK Particle Technology Forum, 2011-12-04, University of Loughborough.

Poulter, N., Donaldson, M., Mulley, G., Duque, L., Waterfield, N., Shard, A. G., Spencer, S., Jenkins, A. T. A. and Johnson, A. L., 2011. Plasma deposited metal Schiff-base compounds as antimicrobials. New Journal of Chemistry, 35 (7), pp. 1477-1484.

Touahir, L., Jenkins, A. T. A., Boukherroub, R., Gouget-Laemmel, A. C., Chazalviel, J. N., Peretti, J., Ozanam, F. and Szunerits, S., 2010. Surface plasmon-enhanced fluorescence spectroscopy on silver based SPR substrates. Journal of Physical Chemistry C, 114 (51), pp. 22582-22589.

Cummings, C. Y., Roweth, A. H., Ching, A. K. Z., Jenkins, A. T. A., Mitchels, J. M., Shariki, S., Liew, S. Y., Thielemans, W., Walsh, D. A. and Marken, F., 2010. Facile cation electro-insertion into layer-by-layer assembled iron phytate films. Electrochemistry Communications, 12 (12), pp. 1722-1726.

Tun, T. N. and Jenkins, A. T. A., 2010. An electrochemical impedance study of the effect of pathogenic bacterial toxins on tethered bilayer lipid membrane. Electrochemistry Communications, 12 (10), pp. 1411-1415.

Jenkins, A. T. A. and Young, A., 2010. Smart dressings for the prevention of infection in pediatric burns patients. Expert Review of Anti-Infective Therapy, 8 (10), pp. 1063-1065.

Gilbert, L., Browning, S., Jenkins, A. T. A. and Hart, J. P., 2010. Studies towards an amperometric phosphate ion biosensor for urine and water analysis. Microchimica Acta, 170 (3-4), pp. 331-336.

Zhou, J., Loftus, A. L., Mulley, G. and Jenkins, A. T. A., 2010. A thin film detection/response system for pathogenic bacteria. Journal of the American Chemical Society, 132 (18), pp. 6566-6570.

Jones, R. T., Sanchez-Contreras, M., Vlisidou, I., Amos, M. R., Yang, G., Munoz-Berbel, X., Upadhyay, A., Potter, U. J., Joyce, S. A., Ciche, T. A., Jenkins, A. T. A., Bagby, S., ffrench-Constant, R. H. and Waterfield, N. R., 2010. Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment. BMC Microbiology, 10, 141.

Meierhofer, T., van den Elsen, J. M. H., Cameron, P. J., Munoz-Berbel, X. and Jenkins, A. T. A., 2010. The interaction of serum albumin with cholesterol containing lipid vesicles. Journal of Fluorescence, 20 (1), pp. 371-376.

Bonne, M. J., Galbraith, E., James, T. D., Wasbrough, M. J., Edler, K. J., Jenkins, A. T. A., Helton, M., McKee, A., Thielemans, W., Psillakis, E. and Marken, F., 2010. Boronic acid dendrimer receptor modified nanofibrillar cellulose membranes. Journal of Materials Chemistry, 20 (3), pp. 588-594.

Poulter, N., Munoz-Berbel, X., Johnson, A. L., Dowling, A. J., Waterfield, N. and Jenkins, A. T. A., 2009. An organo-silver compound that shows antimicrobial activity against Pseudomonas aeruginosa as a monomer and plasma deposited film. Chemical Communications, 2009 (47), pp. 7312-7314.

Gilbert, L., Jenkins, A. T. A., Browning, S. and Hart, J. P., 2009. Development of an amperometric assay for phosphate ions in urine based on a chemically modified screen-printed carbon electrode. Analytical Biochemistry, 393 (2), pp. 242-247.

Muir, A., Jenkins, A. T. A., Forrest, G., Clarkson, J. and Wheals, A., 2009. Rapid electrochemical identification of pathogenic Candida species. Journal of Medical Microbiology, 58 (9), pp. 1182-1189.

Elfeky, S. A., D'Hooge, F., Poncel, L., Chen, W. B., Perera, S. P., van den Elsen, J. M. H., James, T. D., Jenkins, A. T. A., Cameron, P. J. and Fossey, J. S., 2009. A surface plasmon enhanced fluorescence sensor platform. New Journal of Chemistry, 33 (7), pp. 1466-1469.

Mir, M., Jenkins, A. T. A. and Katakis, I., 2008. Ultrasensitive detection based on an aptamer beacon electron transfer chain. Electrochemistry Communications, 10 (10), pp. 1533-1536.

D'Hooge, F., Rogalle, D., Thatcher, M. J., Perera, S., van den Elsen, J. M. H., Jenkins, T. A., James, T. and Fossey, J., 2008. Polymerisation resistant synthesis of methacrylamido phenylboronic acids. Polymer, 49 (16), pp. 3362-3365.

Williams, T. L. and Jenkins, A. T. A., 2008. Measurement of the binding of cholera toxin to GM1 gangliosides on solid supported lipid bilayer vesicles and inhibition by europium (III) chloride. Journal of the American Chemical Society, 130 (20), pp. 6438-6443.

Atkins, K. L., Burman, J. D., Chamberlain, E. S., Cooper, J. E., Poutrel, B., Bagby, S., Jenkins, T. A., Feil, E. J. and van den Elsen, J. M. H., 2008. S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation. Molecular Immunology, 45 (6), pp. 1600-1611.

Vockenroth, I. K., Atanasova, P. P., Jenkins, A. T. A. and Koper, I., 2008. Incorporation of alpha-hemolysin in different tethered bilayer lipid membrane architectures. Langmuir, 24 (2), pp. 496-502.

Jackson, T. R., Springall, J. S., Rogalle, D., Masurnoto, N., Li, H. C., D'Hooge, F., Perera, S. P., Jenkins, A. T. A., James, T. D., Fossey, J. S. and van den Elsen, J. M. H., 2008. Boronate affinity saccharide electrophoresis:A novel carbohydrate analysis tool. Electrophoresis, 29 (20), pp. 4185-4191.

Munoz-Berbel, X., Vigues, N., Jenkins, A. T. A., Mas, J. and Munoz, F. J., 2008. Impedimetric approach for quantifying low bacteria concentrations based on the changes produced in the electrode-solution interface during the pre-attachment stage. Biosensors and Bioelectronics, 23 (10), pp. 1540-1546.

Cameron, P. J., Jenkins, A. T. A., Knoll, W., Marken, F., Milsom, E. V. and Williams, T. L., 2008. Optical waveguide spectroscopy study of the transport and binding of cytochrome c in mesoporous titanium dioxide electrodes. Journal of Materials Chemistry, 18 (36), pp. 4304-4310.

Garcia-Aljaro, C., Munoz-Berbel, X., Jenkins, A. T. A., Blanch, A. R. and Munoz, F. X., 2008. Surface plasmon resonance assay for real-time monitoring of somatic coliphages in wastewaters. Applied and Environmental Microbiology, 74 (13), pp. 4054-4058.

Vareiro, M., Tranchant, I., Maplin, S., Zak, K., Gani, M. M., Slevin, C. J., Hailes, H. C., Tabor, A. B., Cameron, P. J., Jenkins, A. T. A. and Williams, D. E., 2008. Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: Demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid. Analytical Biochemistry, 377 (2), pp. 243-250.

Vockenroth, I. K., Fine, D., Dodobalapur, A., Jenkins, A. T. A. and Koper, I., 2008. Tethered bilayer lipid membranes with giga-ohm resistances. Electrochemistry Communications, 10 (2), pp. 323-328.

This list was generated on Tue May 23 14:39:22 2017 IST.

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