Department of Chemistry

toby_jenkins

Lecturer

1 South 0.12

Email: A.T.A.Jenkins@bath.ac.uk

Tel: +44 (0) 1225 386118 

 

Dr Toby Jenkins

Profile

Research in the group is focussed on four main areas:

1. Development and testing of new materials for clinical and biological applications. As part of a European Commission funded 7th Framework programme we are developing innovative anti-microbial coatings. To be applied to medical devices such as catheters, wound dressings and personal care items, these are based on novel organo-silver, organo-copper and organo-zinc complexes, developed by the group in collaboration with Dr Andrew Johnson’s group.

2. Study of biomimetic lipid membrane - bacterial toxin interaction. Using solid supported lipid bilayer vesicles with encapsulated dye, in the study of how bacterial toxins, such as cholera and α-haemolysin interact with cell membranes. By combining Surface Plasmon Resonance (SPR) and SPR enhanced Fluorescence, observations of both toxin binding to lipid bilayer membranes and any resultant permeabilisation are made.

3. Sensors for clinical microbiology. With Atlas Genetics, a University of Bath spin-out company, we have developed a Point-of-Care test for the fast diagnosis of infection for various microbial pathogens, including Streptococcus pyrogenes, Candida albicans and Neisseria meningitidis. The test utilises an on-chip PCR amplification of target gene sequences and coupled electrochemical detection.

4. Advanced wound dressings. A newly emerging area of research, in collaboration with clinicians and paediatricians at the Paediatrics Burns Unit for the South West of England at Frenchay Hospital, Bristol.

Publications

Malzahn, K., Jamieson, W. D., Dröge, M., Mailänder, V., Jenkins, A. T. A., Weiss, C. K. and Landfester, K., 2014. Advanced dextran based nanogels for fighting Staphylococcus aureus infections by sustained zinc release. Journal of Materials Chemistry C, 2 (15), pp. 2175-2183.

Mulley, G., Jenkins, A.T.A. and Waterfield, N.R., 2014. Inactivation of the antibacterial and cytotoxic properties of silver ions by biologically relevant compounds. PLoS ONE, 9 (4).

Laabei, M., Jamieson, W. D., Massey, R. C. and Jenkins, A. T. A., 2014. Staphylococcus aureus Interaction with Phospholipid Vesicles – A New Method to Accurately Determine Accessory Gene Regulator (agr) Activity. PLoS ONE, 9 (1), e87270.

Pérez Esteban, P., Alves, D., Enright, M. C., Bean, J. E., Gaudion, A., Jenkins, A. T. A., Young, A. E. R. and Arnot, T. C., 2014. Forthcoming. Enhancement of the antimicrobial properties of bacteriophage-K via stabilisation using oil-in-water nano-emulsions. Biotechnology Progress

Thet, N.T., Jamieson, W.D., Laabei, M., Mercer-Chalmers, J.D. and Jenkins, A.T.A., 2014. Photopolymerization of polydiacetylene in hybrid liposomes : Effect of polymerization on stability and response to pathogenic bacterial toxins. Journal of Physical Chemistry B, 118 (20), pp. 5418-5427.

Marshall, S.E., Hong, S.-H., Thet, N.T. and Jenkins, A.T.A., 2013. Effect of lipid and fatty acid composition of phospholipid vesicles on long-term stability and their response to Staphylococcus aureus and Pseudomonas aeruginosa supernatants. Langmuir, 29 (23), pp. 6989-6995.

Feng, C.-L., Dou, X.-Q., Liu, Q.-L., Zhang, W., Gu, J.-J., Zhu, S.-M., Jenkins, A. T. A. and Zhang, D., 2013. Dual-specific interaction to detect DNA on gold nanoparticles. Sensors, 13 (5), pp. 5749-5756.

Marshall, S., Jenkins, A. T. A., Al-Bataineh, S. A., Short, R. D., Hong, S.-H., Thet, N. T., Oh, J.-S., Bradley, J. W. and Stili, E. J., 2013. Studying the cytolytic activity of gas plasma with self-signalling phospholipid vesicles dispersed within a gelatin matrix. Journal of Physics D: Applied Physics, 46 (18), 185401.

Thet, N.T., Hong, S.H., Marshall, S., Laabei, M. and Jenkins, A. T. A., 2013. Visible, colorimetric dissemination between pathogenic strains of Staphylococcus aureus and Pseudomonas aeruginosa using fluorescent dye containing lipid vesicles. Biosensors and Bioelectronics, 41 (1), pp. 538-543.

Bull, S.D., Davidson, M.G., Van Den Elsen, J.M.H., Fossey, J.S., Jenkins, A.T.A., Jiang, Y.-B., Kubo, Y., Marken, F., Sakurai, K., Zhao, J. and James, T.D., 2013. Exploiting the reversible covalent bonding of boronic acids : Recognition, sensing, and assembly. Accounts of Chemical Research, 46 (2), pp. 312-326.

Fossey, J.S., D'Hooge, F., van den Elsen, J.M.H., Pereira Morais, M.P., Pascu, S.I., Bull, S.D., Marken, F., Jenkins, A.T.A., Jiang, Y.-B. and James, T.D., 2012. The development of boronic acids as sensors and separation tools. Chemical Record, 12 (5), pp. 464-478.

Laabei, M., Young, A. and Jenkins, A. T. A., 2012. In vitro studies of toxic shock toxin-1-secreting staphylococcus aureus and implications for burn care in children. Pediatric Infectious Disease Journal, 31 (5), e73-e77.

Jenkins, T., 2012. Anti-microbial burn dressing fights bacterial infection: University of Bath research. University of Bath.

D'Hooge, F., Elfeky, S. A., Flower, S., Pascu, S. I., Jenkins, A. T. A., van den Elsen, J., James, T. and Fossey, J., 2012. Biotinylated boronic acid fluorophore conjugates: quencher elimination strategy for imaging and saccharide detection. RSC Advances, 2, pp. 3274-3280.

Jenkins, T., 2012. Novel Responsive Antimicrobial Dressing. University of Bath.

James, C., Johnson, A. L. and Jenkins, A. T. A., 2011. Antimicrobial surface grafted thermally responsive PNIPAM-co-ALA nano-gels. Chemical Communications, 47 (48), pp. 12777-12779.

Zhou, J., Tun, T. N., Hong, S.-H., Mercer-Chalmers, J. D., Laabei, M., Young, A. E. R. and Jenkins, A. T. A., 2011. Development of a prototype wound dressing technology which can detect and report colonization by pathogenic bacteria. Biosensors and Bioelectronics, 30 (1), pp. 67-72.

Gilbert, L., Jenkins, A. T. A., Browning, S. and Hart, J. P., 2011. Development of an amperometric, screen-printed, single-enzyme phosphate ion biosensor and its application to the analysis of biomedical and environmental samples. Sensors and Actuators B-Chemical, 160 (1), pp. 1322-1327.

Johnson, Andrew, 2011. Antimicrobial coatings. C09D5/14-EP2389419(A1), 03 November 2011.

Tun, T. N., Cameron, P. J. and Jenkins, A. T. A., 2011. Sensing of pathogenic bacteria based on their interaction with supported bilayer membranes studied by impedance spectroscopy and surface plasmon resonance. Biosensors and Bioelectronics, 28 (1), pp. 227-231.

Williams, T. L., Johnson, B. R. G., Urbanc, B., Jenkins, A. T. A., Connell, S. D. A. and Serpell, L. C., 2011. Aβ42 oligomers, but not fibrils, simultaneously bind to and cause damage to ganglioside-containing lipid membranes. Biochemical Journal, 439 (1), pp. 67-77.

Jenkins, A. T. A., Thet, N. T., Zhou, J., Hong, S. H. and Marshall, S., 2011. A microbiologically sensitive “intelligent” burns dressing concept. Burns, 37 (Supplement 1), S5.

Foerch, Renate, 2011. Active antimicrobial compositions, coatings and methods for controlling pathogenic bacteria. A01N25/28-EP2361502(A1), 31 August 2011.

James, C., Pugh, T., Johnson, A. L. and Jenkins, A. T. A., 2011. An antimicrobial zinc based molecule for cross linking poly-acrylic acid. European Polymer Journal, 47 (6), pp. 1338-1345.

Poulter, N., Donaldson, M., Mulley, G., Duque, L., Waterfield, N., Shard, A. G., Spencer, S., Jenkins, A. T. A. and Johnson, A. L., 2011. Plasma deposited metal Schiff-base compounds as antimicrobials. New Journal of Chemistry, 35 (7), pp. 1477-1484.

Touahir, L., Jenkins, A. T. A., Boukherroub, R., Gouget-Laemmel, A. C., Chazalviel, J. N., Peretti, J., Ozanam, F. and Szunerits, S., 2010. Surface plasmon-enhanced fluorescence spectroscopy on silver based SPR substrates. Journal of Physical Chemistry C, 114 (51), pp. 22582-22589.

Cummings, C. Y., Roweth, A. H., Ching, A. K. Z., Jenkins, A. T. A., Mitchels, J. M., Shariki, S., Liew, S. Y., Thielemans, W., Walsh, D. A. and Marken, F., 2010. Facile cation electro-insertion into layer-by-layer assembled iron phytate films. Electrochemistry Communications, 12 (12), pp. 1722-1726.

Tun, T. N. and Jenkins, A. T. A., 2010. An electrochemical impedance study of the effect of pathogenic bacterial toxins on tethered bilayer lipid membrane. Electrochemistry Communications, 12 (10), pp. 1411-1415.

Jenkins, A. T. A. and Young, A., 2010. Smart dressings for the prevention of infection in pediatric burns patients. Expert Review of Anti-Infective Therapy, 8 (10), pp. 1063-1065.

Gilbert, L., Browning, S., Jenkins, A. T. A. and Hart, J. P., 2010. Studies towards an amperometric phosphate ion biosensor for urine and water analysis. Microchimica Acta, 170 (3-4), pp. 331-336.

Zhou, J., Loftus, A. L., Mulley, G. and Jenkins, A. T. A., 2010. A thin film detection/response system for pathogenic bacteria. Journal of the American Chemical Society, 132 (18), pp. 6566-6570.

Jones, R. T., Sanchez-Contreras, M., Vlisidou, I., Amos, M. R., Yang, G., Munoz-Berbel, X., Upadhyay, A., Potter, U. J., Joyce, S. A., Ciche, T. A., Jenkins, A. T. A., Bagby, S., ffrench-Constant, R. H. and Waterfield, N. R., 2010. Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment. BMC Microbiology, 10, 141.

Meierhofer, T., van den Elsen, J. M. H., Cameron, P. J., Munoz-Berbel, X. and Jenkins, A. T. A., 2010. The interaction of serum albumin with cholesterol containing lipid vesicles. Journal of Fluorescence, 20 (1), pp. 371-376.

Bonne, M. J., Galbraith, E., James, T. D., Wasbrough, M. J., Edler, K. J., Jenkins, A. T. A., Helton, M., McKee, A., Thielemans, W., Psillakis, E. and Marken, F., 2010. Boronic acid dendrimer receptor modified nanofibrillar cellulose membranes. Journal of Materials Chemistry, 20 (3), pp. 588-594.

Poulter, N., Munoz-Berbel, X., Johnson, A. L., Dowling, A. J., Waterfield, N. and Jenkins, A. T. A., 2009. An organo-silver compound that shows antimicrobial activity against Pseudomonas aeruginosa as a monomer and plasma deposited film. Chemical Communications, 2009 (47), pp. 7312-7314.

Gilbert, L., Jenkins, A. T. A., Browning, S. and Hart, J. P., 2009. Development of an amperometric assay for phosphate ions in urine based on a chemically modified screen-printed carbon electrode. Analytical Biochemistry, 393 (2), pp. 242-247.

Muir, A., Jenkins, A. T. A., Forrest, G., Clarkson, J. and Wheals, A., 2009. Rapid electrochemical identification of pathogenic Candida species. Journal of Medical Microbiology, 58 (9), pp. 1182-1189.

Elfeky, S. A., D'Hooge, F., Poncel, L., Chen, W. B., Perera, S. P., van den Elsen, J. M. H., James, T. D., Jenkins, A. T. A., Cameron, P. J. and Fossey, J. S., 2009. A surface plasmon enhanced fluorescence sensor platform. New Journal of Chemistry, 33 (7), pp. 1466-1469.

Mir, M., Jenkins, A. T. A. and Katakis, I., 2008. Ultrasensitive detection based on an aptamer beacon electron transfer chain. Electrochemistry Communications, 10 (10), pp. 1533-1536.

D'Hooge, F., Rogalle, D., Thatcher, M. J., Perera, S., van den Elsen, J. M. H., Jenkins, T. A., James, T. and Fossey, J., 2008. Polymerisation resistant synthesis of methacrylamido phenylboronic acids. Polymer, 49 (16), pp. 3362-3365.

Williams, T. L. and Jenkins, A. T. A., 2008. Measurement of the binding of cholera toxin to GM1 gangliosides on solid supported lipid bilayer vesicles and inhibition by europium (III) chloride. Journal of the American Chemical Society, 130 (20), pp. 6438-6443.

Atkins, K. L., Burman, J. D., Chamberlain, E. S., Cooper, J. E., Poutrel, B., Bagby, S., Jenkins, T. A., Feil, E. J. and van den Elsen, J. M. H., 2008. S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation. Molecular Immunology, 45 (6), pp. 1600-1611.

Vockenroth, I. K., Atanasova, P. P., Jenkins, A. T. A. and Koper, I., 2008. Incorporation of alpha-hemolysin in different tethered bilayer lipid membrane architectures. Langmuir, 24 (2), pp. 496-502.

Jackson, T. R., Springall, J. S., Rogalle, D., Masurnoto, N., Li, H. C., D'Hooge, F., Perera, S. P., Jenkins, A. T. A., James, T. D., Fossey, J. S. and van den Elsen, J. M. H., 2008. Boronate affinity saccharide electrophoresis : A novel carbohydrate analysis tool. Electrophoresis, 29 (20), pp. 4185-4191.

Munoz-Berbel, X., Vigues, N., Jenkins, A. T. A., Mas, J. and Munoz, F. J., 2008. Impedimetric approach for quantifying low bacteria concentrations based on the changes produced in the electrode-solution interface during the pre-attachment stage. Biosensors and Bioelectronics, 23 (10), pp. 1540-1546.

Cameron, P. J., Jenkins, A. T. A., Knoll, W., Marken, F., Milsom, E. V. and Williams, T. L., 2008. Optical waveguide spectroscopy study of the transport and binding of cytochrome c in mesoporous titanium dioxide electrodes. Journal of Materials Chemistry, 18 (36), pp. 4304-4310.

Garcia-Aljaro, C., Munoz-Berbel, X., Jenkins, A. T. A., Blanch, A. R. and Munoz, F. X., 2008. Surface plasmon resonance assay for real-time monitoring of somatic coliphages in wastewaters. Applied and Environmental Microbiology, 74 (13), pp. 4054-4058.

Vareiro, M., Tranchant, I., Maplin, S., Zak, K., Gani, M. M., Slevin, C. J., Hailes, H. C., Tabor, A. B., Cameron, P. J., Jenkins, A. T. A. and Williams, D. E., 2008. Surface plasmon resonance-enhanced fluorescence implementation of a single-step competition assay: Demonstration of fatty acid measurement using an anti-fatty acid monoclonal antibody and a Cy5-labeled fatty acid. Analytical Biochemistry, 377 (2), pp. 243-250.

Vockenroth, I. K., Fine, D., Dodobalapur, A., Jenkins, A. T. A. and Koper, I., 2008. Tethered bilayer lipid membranes with giga-ohm resistances. Electrochemistry Communications, 10 (2), pp. 323-328.

This list was generated on Wed Jul 23 23:39:50 2014 IST.

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