Mass Spectrometry is a sensitive technique used to identify and quantify compounds based on their mass, charge, structure and elemental composition. It has many applications including:
- Organic and inorganic synthesis product confirmation
- Protein identification
- Impurity profiling
- Identification of unknowns
- Reaction monitoring
- Environmental screening
Application notes
Learn how to routinely quantitate amino acids, with additional untargeted analysis capabilities, using mass spectrometry.
Read on to learn how TD-GC-MS can be used for the detection of volatile compounds.
Read this quick introduction to what MALDI-TOF-MS can do and how it works.
Our equipment
Automated Agilent QTOF (Walkup) used with HPLC (4 chromatography columns) for routine small molecule, peptide and intact protein analysis.
Agilent GC-MSD equipped with Thermal Desorption for volatile and semi-volatile organic compound (VOC, sVOC) gas chromatographic analysis.
Bruker MaXis HD ESI-QTOF mass spectrometer for high mass accuracy, coupled to a Thermo Scientific Dionex Ultra High Performance Liquid Chromatography (UPLC) unit.
Bruker AutoFlex Matrix-Assisted Laser Desorption Ionisation (MALDI) mass spectrometer for polymer and peptide analysis.
Bruker MicrOTOF Quadrupole Time-Of-Flight (ESI-QTOF) coupled to a syringe driver within a glove box, for air- and moisture-sensitive samples (part of the DReaM Facility).
Hiden HPR20 headspace mass spectrometer, detecting species from 1 - 300 AMU (part of the DReaM Facility).
We are also equipped with a stand-alone UPLC coupled to a UV detector (Dionex Thermo Scientific 3000 RS) for routine UV-purity determinations, including chiral separation of molecules, dependant on column availability.
Internal users
Please see our Moodle page.