Microscopy and Analysis Suite

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Our bioimaging facilities were created jointly by the Wellcome Trust and the University.

The instruments are employed in a variety of different projects, including studies of inflammatory diseases, stem cell biology, diabetes, neuroscience and developmental biology.

To use Bioimaging facilities please contact Anne Gesell (a.gesell@bath.ac.uk).

Confocal laser scanning microscopes

The Confocal laser scanning microscopes enable researchers to create detailed 3D pictures of cell organelles and to examine ‘live’ cells through incubation systems that facilitate the study of cellular changes over time.

MAS houses two Zeiss confocal laser scanning microscopes.


lsm510The Zeiss LSM510META features include:

  • 4 lasers including a 405nm blue diode laser.
  • A META scanning module with 2 single channel detectors & a polychromatic 32-channel detector for fast aquisition of lambda stacks & metatracking.
  • Software that allows emission fingerprinting for crosstalk-free multiple-fluorescence images with fast simultaneous excitation.
  • An environmental chamber fitted to the microscope allowing control of the environment surrounding the sample under study.

LSM880 with Airyscan and Multiphoton laser

The Zeiss LSM880 features include:

  • 34 channel confocal detection system (2 x PMT and 32 channel GaAsP array).
  • 7 laser lines (405, 458, 488, 514, 561, 594nm and 633nm).
  • Inverted Axio Observer microscope.
  • Wide range of objective lenses.
  • ZEN software platform with easy acquisition setup.
  • Spectra Physics multiphoton laser.

Flow cytometry


The Becton Dickinson flow cytometer FACSCanto™ features include:

  • True 6-color capability and high sensitivity optics.
  • Fixed optical alignment - so no lengthy alignment is required before analysis.


The Becton Dickinson flow cytometer FACSARIA III features include:

  • Patented design ensure that lasers are precisely focused on the sample stream.
  • Fixed alignment minimizes start-up time, improves experiment reproducibility.
  • Wide choice of nozzles lets users sort a wide range of particle sizes - 70, 85, 100, and 130 microns.
  • Automated sort setup, and easy-to-change filters make setup fast and simple.

High content imaging and analysis (HCA)

HCA combines cell biology with automated high-resolution microscopy and data evaluation.

It is used for the detailed study of cellular mechanisms and interactions in multiple samples, for example, studying whether cell division, motility, or protein entry is affected when cells are exposed to external stimuli such as chemical inhibitors.

Information generated using HCA is highly valuable in the study of complex diseases, including cancer and infectious diseases. In drug discovery research, the throughput gained using HCA makes it a valuable technology for drug target identification.

The GE Healthcare IN Cell Analyzer 2000 features include:

  • A flexible, modular, lamp based cellular and subcellular imaging system.
  • Automated imaging in fixed and live cells.
  • High performance hardware and state of the art software for cell analysis.