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Using the new equipment in the Pharmacy & Pharmacology Biomedical Spectroscopy Centre
Using the new equipment in the Pharmacy & Pharmacology Biomedical Spectroscopy Centre
The new Bruker micrOTOF Mass Spectrometer is valued at more than £200,000
The new Bruker micrOTOF Mass Spectrometer is valued at more than £200,000
An example of the end product from the spectrometer - an illustration of a drug molecule binding to a short strand of duplex DNA
An example of the end product from the spectrometer - an illustration of a drug molecule binding to a short strand of duplex DNA

Internal News - 02 January 2007

Pharmacy & Pharmacology Biomedical Spectroscopy Centre is complete

With the arrival of a new Bruker micrOTOF Mass Spectrometer, valued at more than £200,000, the Pharmacy & Pharmacology Biomedical Spectroscopy Centre in 9 West is now fully operational.

The centre, which provides crucial spectroscopic characterisation for the Medicinal Chemistry section of the Department of Pharmacy & Pharmacology, is also equipped with three Nuclear Magnetic Resonance (NMR) Spectrometers that are in continuous use.

Professor Barry Potter, Head of the Medicinal Chemistry Group, said: “This new facility is absolutely critical for the large number of medicinal chemists in our department and will be run continually.

“The department’s recent strategy has been to foster critical mass in Medicinal Chemistry and these services will ensure that our recently-appointed members of staff, with their growing research teams, get the high-quality spectroscopic support they need.”

The Medicinal Chemistry section is involved in research over a wide area of drug design and discovery, for example, there are projects targeting novel anti-cancer therapies and new drugs for the treatments of tuberculosis and depression. The centre provides for the characterisation of molecules prepared in this research, and the techniques used allow the molecular structure of novel compounds to be defined and explored.

The centre was first created in 2005, following the successful move of the three NMR spectrometers from other locations around the campus into their new, specially refurbished, home in 9 West. One of the major driving forces for this was the demolition of 4 West. The University invested in excess of £100,000 to facilitate a very difficult move which required quenching of the liquid helium, and liquid nitrogen cooled superconducting magnets.

The three NMR spectrometers, which operate at a range of frequencies and are suited to different uses, have cost more than £1million in total. The funding came from a variety of sources over the last decade, including a major equipment grant from the Wellcome Trust. The funding for the purchase of the micrOTOF mass spectrometer was provided by Sterix Ltd, a drug discovery spin-out company from the University of Bath and Imperial College London.

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