Dr Anita McGrogan
Profile
Research Interests
Drug use and safety in pregnancy
The pharmacoepidemiology group has an interest in investigating the utilisation and safety of prescribed drugs in pregnancy. This work is being undertaken using the General Practice Research Database (GPRD) where all pregnancies and outcomes have been identified resulting in over 1.2 million pregnancies available for study. Present work includes a project to investigate the utilisation of asthma medications in pregnancy. Likely exposure before and during pregnancy will be determined and mapped by trimester.
Drug use and safety in older people
Older people have the greatest use of prescription medication for the prevention and control of chronic diseases. Prescribing in older people is complex as pharmacodynamic and pharmacokinetic properties change with age: the time taken to clear drugs from the liver and kidney increases as the functionality of these organs decreases with increasing age. Studies have been undertaken to determine the utilisation and safety of specific classes of drugs in older people, for example antipsychotics and antidepressants, however it is important to consider the wider picture: older people are regularly prescribed more than one drug and often have comorbidities that need to be taken into account. Older people rarely take part in clinical trials of medications therefore there is little information available on the safety of medications particularly in the oldest old or the very frail populations or in those with many comorbidities. Key areas for investigation include the utilisation and safety of drugs used long term, in particular the combinations of drugs prescribed, likely indications, comorbidities, key cascade prescribing patterns and how prescribing in older people differs with age. Specific disease areas of interest include disorders of the central nervous system such as Parkinson’s disease, schizophrenia, dementia and Alzheimer’s disease. In studying these diseases in older people consideration must be given to other chronic conditions that they may be suffering from including heart disease, rheumatoid disorders and diabetes; we have extensive experience in studying these disorders using the GPRD.
Publications
Sammon, C. J., McGrogan, A., Snowball, J. and De Vries, C. S., 2013. Pandemic influenza vaccination during pregnancy: an investigation of vaccine uptake during the 2009/10 pandemic vaccination campaign in Great Britain. Human Vaccines and Immunotherapeutics, 9 (4), pp. 913-919.
Sammon, C., Snowball, J., McGrogan, A. and De Vries, C. S., 2012. Evaluating the hazard of foetal death following H1N1 inflenza vaccination: a population based cohort study in the UK GPRD. PLoS ONE, 7 (12), e51734.
Sammon, C. J., McGrogan, A., Snowball, J. and De Vries, C. S., 2012. Factors associated with uptake of seasonal and pandemic influenza vaccine among clinical risk groups in the UK: an analysis using the General Practice Research Database. Vaccine, 30 (14), pp. 2483-2489.
Sammon, C. J., McGrogan, A., Snowball, J. and De Vries, C., 2011. Swine flu vaccination in pregnancy and associated miscarriage risk. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S58-S59.
McGrogan, A., Franssen, C. F. M. and de Vries, C. S., 2011. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrology Dialysis Transplantation, 26 (2), pp. 414-430.
Sammon, C., McGrogan, A., Snowball, J. and De Vries, C., 2010. Factors predictive of H1N1 influenza vaccine uptake among ‘at-risk’ patients in the UK General Practice Research Database. Pharmacoepidemiology and Drug Safety, 19 (S1), 31.
Bloomfield, K., John, N., McGrogan, A., Jones, R. and De Vries, C., 2010. Co-Prescribing of medications with anticholinergic properties to those using cholinesterase inhibitors for dementia. Pharmacoepidemiology and Drug Safety, 19 (S1), 112.
McGrogan, A., Snowball, J. and De Vries, C., 2010. Pregnancy loss in patients with type 1 or type 2 diabetes during pregnancy. Pharmacoepidemiology and Drug Safety, 19 (S1), 498.
McGrogan, A., Sneddon, S. and de Vries, C. S., 2010. The incidence of Myasthenia Gravis: a systematic literature review. Neuroepidemiology, 34 (3), pp. 171-183.
McGrogan, A., Snowball, J. and De Vries, C., 2010. Treatment of diabetes before and during pregnancy. Pharmacoepidemiology and Drug Safety, 19 (S1), 156.
McGrogan, A., Snowball, J. and de Vries, C. S., 2009. Statins and pregnancy outcomes: a cohort study in the GPRD. Pharmacoepidemiology and Drug Safety, 18 (Supplement 1), S75-S76.
Terzakis, I. A., Snowball, J. M., McGrogan, A. and de Vries, C. S., 2009. Utilisation of psychotropic medicines in pregnancy. Pharmacoepidemiology and Drug Safety, 18 (Supplement 1), S78-S78.
McGrogan, A., Madle, G. C., Seaman, H. E. and de Vries, C. S., 2009. The epidemiology of Guillain-Barré Syndrome worldwide. Neuroepidemiology, 32 (2), pp. 150-163.
McGrogan, A., Seaman, H. E., Wright, J. W. and de Vries, C. S., 2008. The incidence of autoimmune thyroid disease: a systematic review of the literature. Clinical Endocrinology, 69 (5), pp. 687-696.
Vroom, F., Snowball, J., McGrogan, A., de Jong-van den Berg, L. and de Vries, C., 2008. GPRD study of pregnancy outcomes following the prescribing of DMARDs. Pharmacoepidemiology and Drug Safety, 17 (Supplement 1), S227-S228.
