Department of Pharmacy and Pharmacology
 

begona_delgado-charro

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5W 2.53

Email: B.Delgado-Charro@bath.ac.uk

Tel: +44 (0) 1225 383969 

 

Dr BegoƱa Delgado-Charro

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Transdermal Drug Delivery by Iontophoresis

Iontophoresis - the use of an electrical potential gradient to promote the transdermal penetration of charged molecules - is perhaps the most powerful, yet relatively non-invasive approach available at present to enhance molecular permeability across intact skin.

Present work focuses on better understanding the complex dependence of transport number upon the concentration and mobility of all the ions present at both sides of the skin, and the physicochemical properties which determine iontophoretic drug fluxes. A project funded by the Parkinson's Disease Society, UK screened the feasibility of a transdermal iontophoretic administration of anti-Parkinsonian drugs. A project funded by the MRC in collaboration with Dr S. Husbands, Dr C. Bailey and Prof. R. Guy currently looks into the development of an iontophoretic patch to treat drug addiction.

Non-Invasive Drug Monitoring, Clinical Chemistry and Pharmacokinetics

Non-invasive sampling methodologies provide more information as sampling can be performed more frequently, they decreased pain and discomfort, risk of infection, and offer potential for home-monitoring, etc.

We currently investigate the use of "reverse iontophoresis" as a non-invasive approach for therapeutic drug monitoring, clinical chemistry, assessment of chemical exposure and skin health, and pharmacokinetic profiling via the skin. Complementary work uses tape-stripping to interrogate the Stratum Corneum and collaboration with Dr White (Mathematical Sciences) aims to model how chemical accumulate into the skin.

Nail Drug Delivery

The current treatment of nail diseases such as psoriasis and onychomycosis is far from optimal. Unfortunately, the available topical therapies are not very efficient. We use iontophoresis as a tool to enhance trans-ungual transport of antifungal drugs into and across the nail plate and investigate other formulation alternatives.

Publications

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