Department of Pharmacy and Pharmacology

charareh_pourzand

Reader in Pharmaceutics
5 West - 4.3c

E-mail: prscap@bath.ac.uk

Tel: +44 (0) 1225 383590 

 

Dr Charareh Pourzand 

Profile

The research program in my laboratory has its primary focus on characterization of iron-related early cellular events promoting various pathological types of damage to human skin cells either as a result of acute/chronic exposure to oxidizing agents such as ultraviolet A (UVA, 320-400nm) radiation and hydrogen peroxide or as a result of alteration in iron homeostasis observed in a series of iron-related skin disorders such as skin cancer and Psoriasis. The results obtained from these studies provide us with valuable knowledge to design a series of synthetic small molecules with iron chelation and antioxidant properties that may be used as therapeutic tools to prevent the promotion or progression of such disorders.

Current research in my laboratory focuses on:

Design and study of novel ‘light-activated caged-iron chelators’

We have developed a series of novel light-activated ‘caged’ iron chelators that minimize the side effects of prolonged siderophore exposure. These compounds are inactive due to temporary blockade of the iron binding site and only become activated upon exposure to an external light source. Current research involves the evaluation of both photoprotective and therapeutic potential of CICs in both monolayer and organotypic (artificial) three dimensional skin cultures.

Design and study of novel ‘organelle-targeted’ iron sensors/chelators

Recent studies of a range of human disorders as well as cellular studies with environmental oxidizing agents such as UVA have indicated that mitochondrial and lysosomal redox active and chelatable labile iron plays a key role in conferring cellular sensitivity to oxidative damage and the resulting pathologies and cell death. Iron chelators that target specifically the mitochondrial and lysosomal iron could therefore be beneficial both as preventive and therapeutic agents. Current research involves the evaluation of the exact role of subcellular labile iron distribution (or misdistribution) in oxidative injuries and iron-related disorders.

Publications

Reelfs, O., Abbate, V., Hider, R. C. and Pourzand, C., 2016. A powerful mitochondria-targeted iron chelator affords high photoprotection against solar ultraviolet A radiation. Journal Of Investigative Dermatology, 136 (8), pp. 1692-1700.

Reelfs, O., Abbate, V., Hider, R. C. and Pourzand, C., 2016. Evaluation of the photoprotective potential of novel hexadentate iron chelators against sunlight-induced damage to skin cells. In: 6th Meeting of the International BioIron Society, 2015, 2015-07-06 - 2015-09-10, Zhejiang University.

Reelfs, O., Abbate, V., Hider, R. C. and Pourzand, C., 2016. Characterisation Of A Novel Hexadentate Iron Chelator For Skin Photoprotection.

Houshmandyar, S., Reelfs, O., Radka, T., Eggleston, I. and Pourzand, C., 2016. Clinical Iron Chelators For Skin Photoprotection As Light-Activated Caged Iron Chelators.

Houshmandyar, S., Reelfs, O., Radka, T., Eggleston, I. and Pourzand, C., 2016. Deferiprone And Deferasirox As Promissing Candidate Ligands For Skin Photoprotection By Light-Activated Caged-Iron Chelators. American Journal of Hematology, 91 (3), E69-E69.

Hider, R. C., Abbate, V., Reelfs, O. and Pourzand, C., 2016. Design of novel fluorescent mitochondria-targeted peptides with iron selective sensing activity. American Journal of Hematology, 91 (3), E39-E39.

Abbate, V., Reelfs, O., Hider, R. C. and Pourzand, C., 2015. Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity. Biochemical journal, 469 (3), pp. 357-366.

Pourzand, C., Reelfs, O., Abbate, V. and Hider, R. C., 2015. Novel mitochondria-targeted peptide iron chelators for iron sensing and protection against oxidative stress-induced mitochondrial damage. The Journal of World Mitochondria Society

Reelfs, O., Abbate, V., Hider, R. C. and Pourzand, C., 2014. Design of novel mitochondria-targeted fluorescent iron sensor for the monitoring of mitochondrial labile iron pool level. In: Targeting Mitochondria World Congress 2014, 2014-10-29 - 2014-10-31.

Reelfs, O., Young, B., Radka, T., Eggleston, I. and Pourzand, C., 2014. A novel generation of photoactivatable caged-iron chelators with both antioxidant and iron chelation properties for skin photoprotection. In: European Iron Club 2014, 2014-09-11 - 2014-09-14.

Reelfs, O., Abbate, V., Hider, R. C. and Pourzand, C., 2014. Design of a Novel Mitochondria-targeted Fluorescent Iron Sensor for the Monitoring of Mitochondrial Labile Iron Pool Level. In: European Iron Club 2014, 2014-09-11 - 2014-09-14.

Radka, T., Reelfs, O., Dondi, R., Eggleston, I. and Pourzand, C., 2014. UVA-activatable caged iron chelators significantly improve the efficiency of topical aminolevulinate-based photodynamic therapy of skin cancer.

Al-Qenaei, A., Yiakouvaki, A., Reelfs, O., Santambrogio, P., Levi, S., Hall, N. D., Tyrrell, R. M. and Pourzand, C., 2014. Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide. Free Radical Biology and Medicine, 68, pp. 87-100.

Pourzand, Charareh, 2014. Preparation of UV radiation cleavable compounds. PCT Int. Appl.- WO 2014041362, 2014.

Reelfs, O., Young, B., Aroun, A., Hoffmann, M., Miri, S. A., Richardson, D. R., Eggleston, I. and Pourzand, C., 2013. A comparative study of the antiprolifrative activity of thiosemicarbazone iron chelators in skin cells. American Journal of Hematology, 88 (5), E170-E170.

Radka, T., Reelfs, O., Dondi, R., Eggleston, I. and Pourzand, C., 2013. Improving the efficiency of aminolevulinate-photodynamic therapy of skin cancer by combining uva irradiation and potent iron chelating agents. American Journal of Hematology, 88 (5), E170-E171.

Young, B., Reelfs, O., Aroun, A., Eggleston, I. and Pourzand, C., 2013. Light-activatable and photo-controlled caged-nih, a promising pro-iron chelator for the topical therapy of skin cancer. American Journal of Hematology, 88 (5), E177-E177.

Abbate, V., Hider, R. C., Pourzand, C. and Reelfs, O., 2013. Mitochondia-targeted iron chelators for the monitoring and adjustment of cellular labile iron pools. In: Fifth Congress of the International BioIron Society (IBIS), 2013-04-13 - 2013-04-17.

Abbate, V., Hider, R. C., Reelfs, O. and Pourzand, C., 2013. Mitochondria-targeted iron chelators for the monitoring and adjustment of cellular labile iron pools. American Journal of Hematology, 88 (5), E68-E68.

Young, B., Reelfs, O., Aroun, A., Miri, S. A., Hoffmann, M., Pourzand, C. and Eggleston, I., 2013. Novel light-activated caged iron chelators: targeted prodrugs for iron related-disorders. American Journal of Hematology, 88 (5), E176-E176.

Metwally, A. A., Reelfs, O., Pourzand, C. and Blagbrough, I. S., 2012. Efficient silencing of EGFP reporter gene with siRNA delivered by asymmetrical N4,N9-diacyl spermines. Molecular Pharmaceutics, 9 (7), pp. 1862-1876.

Aroun, A., Zhong, J. L., Tyrrell, R. M. and Pourzand, C., 2012. Iron, oxidative stress and the example of solar ultraviolet A radiation. Photochemical & Photobiological Sciences, 11 (1), pp. 118-134.

Metwally, A. A., Reelfs, O., Pourzand, C. and Blagbrough, I. S., 2011. Asymmetrical N4,N9-diacyl spermines: SAR and their efficiency as siRNA delivery vectors compared with symmetrical mixtures. Human Gene Therapy, 22 (10), A84-A85.

Pelle, E., Jian, J. L., Declercq, L., Dong, K., Yang, Q., Pourzand, C., Maes, D., Pernodet, N., Yarosh, D. B. and Huang, X., 2011. Protection against ultraviolet A-induced oxidative damage in normal human epidermal keratinocytes under post-menopausal conditions by an ultraviolet A-activated caged-iron chelator: a pilot study. Photodermatology Photoimmunology & Photomedicine, 27 (5), pp. 231-235.

Metwally, A. A., Pourzand, C. and Blagbrough, I. A., 2011. Efficient gene silencing by self-assembled complexes of siRNA and symmetrical fatty acid amides of spermine. Pharmaceutics, 3 (2), pp. 125-140.

Metwally, A. A., Pourzand, C. and Blagbrough, I. S., 2010. Efficient siRNA delivery and effective gene silencing by lipoplexes. Drug Discovery Today, 15 (23-24), p. 1090.

Metwally, A. A., Pourzand, C. and Blagbrough, I. S., 2010. Efficient siRNA delivery and gene silencing by unsymmetrical fatty acid amides of spermine. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1220-1221.

Ghonaim, H. M., Cheng, Y. X., Pourzand, C. and Blagbrough, I., 2010. Self-assembled complex formulations of lipid-aminoglycoside conjugates:Nanoparticles for efficient gene and siRNA delivery. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1295-1296.

Reelfs, O., Eggleston, I. M. and Pourzand, C., 2010. Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs. Current Drug Metabolism, 11 (3), pp. 242-249.

Ghonaim, H. M., Ahmed, O. A. A., Pourzand, C. and Blagbrough, I. S., 2008. Varying the chain length in N4,N9-diacyl spermines: non-viral lipopolyamine vectors for efficient plasmid DNA formulation. Molecular Pharmaceutics, 5 (6), pp. 1111-1121.

Mecklenburg, S., Collins, C. A., Doring, M., Burkholz, T., Abbas, M., Fry, F. H., Pourzand, C. and Jacob, C., 2008. The design of multifunctional antioxidants against the damaging ingredients of oxidative stress. Phosphorus Sulfur and Silicon and the Related Elements, 183 (4), pp. 863-888.

This list was generated on Tue Jun 27 01:12:49 2017 IST.

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