Professor of Pharmacoepidemiology
5 West 2.52B
Email: c.de-vries@bath.ac.uk
Tel: +44 (0) 1225 384228
Prof Corinne de Vries
Profile
Most of our research projects involve use of healthcare databases. Between us, we have over 20 years experience of working with the General Practice Research Database (GPRD), a database renowned world-wide for its quality and use for epidemiology research. In addition to the GPRD, I have worked with databases in the Netherlands, Denmark, and Scotland. Our research focus is as follows:
Drug Utilisation and Safety in Vulnerable Groups (such as pregnant women and children)
We have identified all pregnancies recorded on a combination of two versions of the GPRD, namely the version available from EPIC and the version available from the GPRD at the MHRA. Combining these two data sets results in about 30% more data than is available from one source alone; this is important when investigating adverse events in pregnancy associated with drug exposures since statistical power becomes an issue.
As a result, we have information on about 715,000 pregnancies beyond 28 weeks of gestation and about 290,000 spontaneous abortions and terminations of pregnancy. For the data up to April 2007, mother-baby pairs have been identified successfully for about 80% of pregnancies. We have carried out a preliminary study of folic acid antagonists and orofacial cleft, a study investigating the utility of the GPRD compared with a pregnancy registry, and a preliminary study investigating the risk of stillbirths in women with diabetes comparing stillbirth risk associated with different diabetes treatments. In these studies we were able to identify known risk factors and it was encouraging that frequency of recording of stillbirths, as well as the frequency of orofacial cleft was comparable with that found in other sources. Following on from this we are conducting further validation work as well as safety evaluations.
Risk Management and Pharmacoepidemiology using Health Care Databases
Our experience using health care databases in the area of pharmacoepidemiology has stimulated our interest in methodological issues associated with using health care databases for purposes of safety evaluation. As a result, we have conducted research with these databases in a variety of disease areas, especially diabetes mellitus, cardiovascular disease, prostate cancer and rheumatoid disease. A lot of our work has involved hormonal products both for prostate cancer and in oral contraceptives and hormone replacement therapy (please see list of publications below).
- These members are also involved in pharmacoepidemiology research and teaching:
- Julia Snowball
- Annie Hutchison
- Rachel Charlton
- Dr Anita McGrogan
Membership
- Independent Scientific Advisory Committee for MHRA database research (scientific member)
- Committee on Toxicity, Food Standards Agency (expert member)
- Royal Society of Medicine (Fellow)
Publications
Charlton, R. A., Hutchison, A., Davis, K. J. and De Vries, C. S., 2013. Asthma management in pregnancy. PLoS ONE, 8 (4), e60247.
Sammon, C. J., McGrogan, A., Snowball, J. and De Vries, C. S., 2013. Pandemic influenza vaccination during pregnancy: an investigation of vaccine uptake during the 2009/10 pandemic vaccination campaign in Great Britain. Human Vaccines and Immunotherapeutics, 9 (4), pp. 913-919.
Gulmez, S.E., Larrey, D., Pageaux, G.-P., Lignot-Maleyran, S., De Vries, C., Sturkenboom, M., Perez-Gutthann, S., Bénichou, J., Bissoli, F., Horsmans, Y., Bernuau, J., Stricker, B., Thorburn, D., Blin, P. and Moore, N., 2013. Methodology for a multinational case-population study on liver toxicity risks with NSAIDs: the Study of Acute Liver Transplant (SALT). European Journal of Clinical Pharmacology, 69 (3), pp. 605-616.
Wijnans, L., Lecomte, C., de Vries, C., Weibel, D., Sammon, C., Hviid, A., Svanström, H., Mølgaard-Nielsen, D., Heijbel, H., Dahlström, L.A., Hallgren, J., Sparen, P., Jennum, P., Mosseveld, M., Schuemie, M., van der Maas, N., Partinen, M., Romio, S., Trotta, F., Santuccio, C., Menna, A., Plazzi, G., Moghadam, K.K., Ferro, S., Lammers, G.J., Overeem, S., Johansen, K., Kramarz, P., Bonhoeffer, J. and Sturkenboom, M.C.J.M., 2013. The incidence of narcolepsy in Europe : Before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns. Vaccine, 31 (8), pp. 1246-1254.
Gulmez, S.E., Larrey, D., Pageaux, G.-P., Lignot, S., Lassalle, R., Jové, J., Gatta, A., McCormick, P.A., Metselaar, H.J., Monteiro, E., Thorburn, D., Bernal, W., Zouboulis-Vafiadis, I., De Vries, C., Perez-Gutthann, S., Sturkenboom, M., Bénichou, J., Montastruc, J.-L., Horsmans, Y., Salvo, F., Hamoud, F., Micon, S., Droz-Perroteau, C., Blin, P. and Moore, N., 2013. Transplantation for acute liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen) : The multinational case-population SALT study. Drug Safety, 36 (2), pp. 135-144.
Sammon, C., Snowball, J., McGrogan, A. and De Vries, C. S., 2012. Evaluating the hazard of foetal death following H1N1 inflenza vaccination: a population based cohort study in the UK GPRD. PLoS ONE, 7 (12), e51734.
Sammon, C. J., McGrogan, A., Snowball, J. and De Vries, C. S., 2012. Factors associated with uptake of seasonal and pandemic influenza vaccine among clinical risk groups in the UK: an analysis using the General Practice Research Database. Vaccine, 30 (14), pp. 2483-2489.
Tillett, W., De Vries, C. and McHugh, N. J., 2012. Work disability in psoriatic arthritis: a systematic review. Rheumatology, 51 (2), pp. 275-283.
Gülmez, S. E., Lignot-Maleyran, S., De Vries, C. S., Sturkenboom, M., Micon, S., Hamoud, F., Blin, P. and Moore, N., 2012. Administrative complexities for a European observational study despite directives harmonising requirements. Pharmacoepidemiology and Drug Safety, 21 (8), pp. 851-856.
Charlton, R., Snowball, J., Bloomfield, K. and De Vries, C., 2012. Colorectal cancer incidence on the General Practice Research Database. Pharmacoepidemiology and Drug Safety, 21 (7), pp. 775-783.
Blake, K. V., De Vries, C. S., Arlett, P., Kurz, X. and Fitt, H., 2012. Increasing scientific standards, independence and transparency in post-authorisation studies: The role of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance. Pharmacoepidemiology and Drug Safety, 21 (7), pp. 690-696.
Tillett, W., Shaddick, G., Korendowych, E., De Vries, C. S. and McHugh, N., 2012. Joint count reliability in psoriatic arthritis observational trials: an unreported problem. Rheumatology, 51 (7), pp. 1333-1334.
Nightingale, A. L., Hutchison, A. and De Vries, C., 2011. Differences in Oral Candidiasis Risk between Different Inhaled Corticosteroids. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S141.
Dieleman, J. P., Romio, S. S., De Vries, C. S., Sammon, C. J., Andrews, N., Hviid, A., Svanstrom, H., Molgaard-Nielsen, D., Lapeyre-Mestre, M., Sommet, A., Saussier, C., Castot, A., Heijbel, H., Dahlstrom, L. A., Hallgren, J., Sparen, P., Mosseveld, M., Schuemie, M., van der Maas, N., Jacobs, B. C., Johansen, K., Kramarz, P., Weibel, D., Bonhoeffer, J. and Sturkenboom, M., 2011. Guillain-Barre Syndrome and Adjuvanted Pandemic Influenza A (H1N1) 2009 Vaccines - A Multinational Case Control Study in Europe. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S258-S259.
Kurz, X., Leufkens, B., Blackburn, S., Moride, Y., Simmons, V. and De Vries, C., 2011. Increasing Scientific Standards, Transparency and Independence in Pharmacoepidemiological Research: Is the Concept of ENCePP Studies a Way Forward? Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S150.
Charlton, R. A., Snowball, J. M., Bloomfield, K. and De Vries, C. S., 2011. Macrogol laxatives and colorectal cancer risk. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S270-S271.
Gulmez, E. S., Lignot, S., Larrey, D., De Vries, C., Perez-Gutthann, S., Montastruc, J. L., Sturkenboom, M., Benichou, J., Velo, G., Caputi, A., Salvo, F., Hamoud, F., Micon, S., Lassalle, R., Jove, J., Pageaux, G. P., Horsmans, Y., Bernuau, J., Bissoli, F., Stricker, B., Thorburn, D., Gatta, A., Monteiro, E., Vafiadis, I., McCormick, A., Metselaar, H., Sen, E., Nightingale, A., Blin, P. and Moore, N., 2011. NSAID Exposure and Risk of Acute Liver Failure Leading to Transplantation: Preliminary Results of the Study of Acute Liver Transplant (SALT) in 7 European Countries. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S305-S305.
Dieleman, J., Lecomte, C., Schuemie, M., van Rolleghem, A., Hviid, A., Svanstrom, H., Molgaard-Nielsen, D., Jokinen, J., Nohynek, H., Kilpi, T., Storsaeter, J., van der Maas, N., Heijbel, H., Arnheim-Dahlstrom, L., Sparen, P., Sammon, C., De Vries, C., Plazzi, G., Menna, A., Trotta, F., Santuccio, C., Johansen, K., Kramarz, P., Weibel, D., Bonhoeffer, J. and Sturkenboom, M., 2011. Safety of adjuvanted pandemic influenza vaccines: background rate of narcolepsy in Europe. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S260.
Sammon, C. J., McGrogan, A., Snowball, J. and De Vries, C., 2011. Swine flu vaccination in pregnancy and associated miscarriage risk. Pharmacoepidemiology and Drug Safety, 20 (Supplement 1), S58-S59.
Dieleman, J., Romio, S., De Vries, C., Sammon, C., Andrews, N., Hviid, A., Svanström, H., Mølgaard-Nielsen, D., Lapeyre-Mestre, M., Sommet, A., Saussier, C., Castot, A., Heijbel, H., Arnheim Dahlström, L., Hallgren, J., Sparen, P., Mosseveld, M., Schuemie, M., van der Maas, N., Jacobs, B. C., Johansen, K., Kramarz, P., Weibel, D., Bonhoeffer, J. and Sturkenboom, M. C., 2011. Guillain-Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe. BMJ, 343, d3908.
Snook, K. L., Layer, G. T., Jackson, P. A., De Vries, C. S., Shousha, S., Sinnett, H. D., Nigar, E., Singhal, H., Chia, Y., Cunnick, G. and Kissin, M. W., 2011. Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma. British Journal of Surgery, 98 (4), pp. 527-535.
McGrogan, A., Franssen, C. F. M. and de Vries, C. S., 2011. The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrology Dialysis Transplantation, 26 (2), pp. 414-430.
Charlton, R. A., Weil, J. G., Cunnington, M. C., Ray, S. and de Vries, C. S., 2011. Comparing the General Practice Research Database and the UK Epilepsy and Pregnancy Register as tools for postmarketing teratogen surveillance anticonvulsants and the risk of major congenital malformations. Drug Safety, 34 (2), pp. 157-171.
Gulmez, E., Lignot, S., Larrey, D., De Vries, C., Gutthann, S. P., Montastruc, J., Sturkenboom, M., Benichou, J., Velo, G., Caputi, A., Salvo, F., Hamoud, F., Micon, S., Lassalle, R., Jove, J., Pageaux, G., Horsmans, Y., Bernuau, J., Bissoli, F., Stricker, B., Thorburn, D., Gatta, A., Monteiro, E., Vafiadis, I., McCormick, A., Metselaar, H., Sen, E., Nightingale, A., Blin, P. and Moore, N., 2011. NSAID Exposure and Risk of Acute Liver Failure Leading to Transplantation: Principal Results of the 7-Country Case-Population Study (SALT). Drug Safety, 34 (10), p. 895.
Sammon, C., McGrogan, A., Snowball, J. and De Vries, C., 2010. Factors predictive of H1N1 influenza vaccine uptake among ‘at-risk’ patients in the UK General Practice Research Database. Pharmacoepidemiology and Drug Safety, 19 (S1), 31.
Reid, R. L., Westhoff, C., Mansour, D., de Vries, C. S., Verhaeghe, J., Boschitsch, E., Gompel, A., Birkhauser, M., Krepelka, P., Dulicek, P., Iversen, O. E., Khamoshina, M., Dezman, L. V., Fruzzetti, F., Szarewski, A., Wilken-Jensen, C., Seidman, D., Kaaja, R. and Shapiro, S., 2010. Oral contraceptives and venous thromboembolism consensus opinion from an international workshop held in Berlin, Germany in December 2009. Journal of Family Planning and Reproductive Health Care, 36 (3), pp. 117-122.
Bloomfield, K., John, N., McGrogan, A., Jones, R. and De Vries, C., 2010. Co-Prescribing of medications with anticholinergic properties to those using cholinesterase inhibitors for dementia. Pharmacoepidemiology and Drug Safety, 19 (S1), 112.
Charlton, R. A., Weil, J. G., Cunnington, M. C. and de Vries, C., 2010. Identifying major congenital malformations in the UK general practice research database (GPRD): A study reporting on the sensitivity and added value of photocopied medical records and free text in the GPRD. Drug Safety, 33 (9), pp. 741-750.
McGrogan, A., Snowball, J. and De Vries, C., 2010. Pregnancy loss in patients with type 1 or type 2 diabetes during pregnancy. Pharmacoepidemiology and Drug Safety, 19 (S1), 498.
McGrogan, A., Sneddon, S. and de Vries, C. S., 2010. The incidence of Myasthenia Gravis: a systematic literature review. Neuroepidemiology, 34 (3), pp. 171-183.
McGrogan, A., Snowball, J. and De Vries, C., 2010. Treatment of diabetes before and during pregnancy. Pharmacoepidemiology and Drug Safety, 19 (S1), 156.
Hutchison, A., Russell-Jones, D. and de Vries, C. S., 2009. Predictors of drug choice in newly diagnosed type 2 diabetes. Diabetologia, 52 (Supplement 1), p. 314.
Charlton, R. A., Weil, J. G., Snowball, J. M., Cunnington, M. C. and de Vries, C. S., 2009. Can the General Practice Research Database identify a known teratogenic association? Pharmacoepidemiology and Drug Safety, 18 (Supplement 1), S12.
McGrogan, A., Snowball, J. and de Vries, C. S., 2009. Statins and pregnancy outcomes: a cohort study in the GPRD. Pharmacoepidemiology and Drug Safety, 18 (Supplement 1), S75-S76.
Terzakis, I. A., Snowball, J. M., McGrogan, A. and de Vries, C. S., 2009. Utilisation of psychotropic medicines in pregnancy. Pharmacoepidemiology and Drug Safety, 18 (Supplement 1), S78-S78.
Kissin, M. W., Snook, K. L., Layer, G. T., Jackson, P., de Vries, C. S., Shousha, S., Sinnett, H. D., Singhal, H., Nigar, E., Cunnick, G. and Chia, Y., 2009. Intraoperative molecular sentinel lymph node analysis with OSNA: multicentre prospective UK evaluation. Cancer Research, 69 (2 Suppl), 106S.
Charlton, R., Cunnington, M., Weil, J. and de Vries, C. S., 2009. Regarding the need, or lack thereof, of a comparator group for pregnancy registries. Birth Defects Research Part A: Clinical and Molecular Teratology, 85 (9), p. 808.
de Vries, C. S. and Russell-Jones, D. L., 2009. Rosiglitazone or pioglitazone in type 2 diabetes? British Medical Journal, 339, b3076.
McGrogan, A., Madle, G. C., Seaman, H. E. and de Vries, C. S., 2009. The epidemiology of Guillain-Barré Syndrome worldwide. Neuroepidemiology, 32 (2), pp. 150-163.
McGrogan, A., Seaman, H. E., Wright, J. W. and de Vries, C. S., 2008. The incidence of autoimmune thyroid disease: a systematic review of the literature. Clinical Endocrinology, 69 (5), pp. 687-696.
Ballard, K. D., Seaman, H. E., de Vries, C. S. and Wright, J. T., 2008. Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study - Part 1. BJOG : An International Journal Of Obstetrics & Gynaecology, 115 (11), pp. 1382-1391.
Seaman, H. E., Ballard, K. D., Wright, J. T. and de Vries, C. S., 2008. Endometriosis and its coexistence with irritable bowel syndrome and pelvic inflammatory disease: findings from a national case-control study - Part 2. BJOG : An International Journal Of Obstetrics & Gynaecology, 115 (11), pp. 1392-1396.
Mulnier, H. E., Seaman, H. E., Raleigh, V. S., Soedamah-Muthu, S. S., Colhoun, H. M., Lawrenson, R. A. and de Vries, C. S., 2008. Risk of myocardial infarction in men and women with type 2 diabetes in the UK: a cohort study using the General Practice Research Database. Diabetologia, 51 (9), pp. 1639-1645.
Vroom, F., Snowball, J., McGrogan, A., de Jong-van den Berg, L. and de Vries, C., 2008. GPRD study of pregnancy outcomes following the prescribing of DMARDs. Pharmacoepidemiology and Drug Safety, 17 (Supplement 1), S227-S228.
Hutchison, A., Russell-Jones, D., Hordern, V. and de Vries, C. S., 2008. Reduced risk of hypoglycaemia in analogue compared with human insulin: an observational study in the UK. Pharmacoepidemiology and Drug Safety, 17 (Supplement 1), p. 271.
de Vries, C. S., Snowball, J., Russell-Jones, D. and Hutchison, A., 2008. Stillbirth and early neonatal death risk is reduced in those using analogue compared with those using human insulin. Pharmacoepidemiology and Drug Safety, 17 (Supplement 1), 034.
Charlton, R., Weil, J., Curmington, M. and de Vries, C. S., 2008. The general practice research database as a pregnancy registry system: anticonvulsants as an example. Pharmacoepidemiology and Drug Safety, 17 (Supplement 1), 362.
de Vries, C., Nightingale, A. and Farmer, R., 2008. Epidemiology of systemic lupus erythematosus in the United Kingdom: Comment on the article by Somers et al. Arthritis & Rheumatism, 59 (2), p. 297.
Charlton, R. A., Cunnington, M. C., de Vries, C. S. and Weil, J. G., 2008. Data resources for investigating drug exposure during pregnancy and associated outcomes: The General Practice Research Database(GPRD) as an alternative to pregnancy registries. Drug Safety, 31 (1), pp. 39-51.
de Vries, C. S. and de Jong-van den Berg, L. T. W., 2008. Spontane rapportage en farmacoepidemiologie [spontaneous reporting and pharmacoepidemiology]. In: Buurma, H., de Jong-van den Berg, L. T. W. and Leufkens, H. G. M., eds. Het Geneesmiddel, 5th ed. Maarssen: Elsevier.
