Department of Pharmacy and Pharmacology


Senior Lecturer

Office: 5 West 2.18


Dr John Pauling


Dr John Pauling is a consultant rheumatologist at the Royal National Hospital for Rheumatic Diseases (RNHRD) and Senior Lecturer in the Department of Pharmacy & Pharmacology.

John qualified from Nottingham University Medical School in 2002. After completing General Medical training, he commenced Specialty Training in Rheumatology in 2005. He developed a clinical interest in the Connective Tissue Diseases early in his specialty training, particularly in relation to Raynaud’s phenomenon and systemic sclerosis; a rare multisystem disease of unknown aetiology characterised by vasculopathy, fibrosis and autoimmunity.

In 2009 he was awarded the Dando fellowship, jointly funded by the RSA and Royal College of Physicians. His PhD research, undertaken under the supervision of Professor Neil McHugh at the University of Bath, evaluated the potential contribution of platelets to microvascular dysfunction in primary Raynaud’s phenomenon (RP) and systemic sclerosis (SSc). This work has helped John to develop an interest in outcome measures in SSc research, particularly in relation to peripheral microvascular dysfunction in scleroderma. John has interests in non-invasive methods of measuring tissue perfusion such as infra-red thermography and laser-derived imaging modalities. He has undertaken early validation studies of laser speckle contrast imaging (LSCI) in RP and SSc. He is interested in the relationship between peripheral microcirculatory function and circulating vascular biomarkers.

John also leads the RNHRD Rheumatoid Arthritis service and has developed an interest in predictors of treatment response to biologics in rheumatoid arthritis (RA). Dr Pauling is working with the British Society of Rheumatology Biologics Register (BSR-BR) to identify factors influencing treatment responses to biologic therapy in RA.

John leads the microvascular imaging service at RNHRD and is a member of the EULAR Microcirculation study group. He is contributing to current initiatives of the UK Scleroderma Study Group and the Scleroderma Clinical Trials Consortium (SCTC). He co-chairs the SCTC Vascular Working Group that is currently working on developing better methods for assessing peripheral microvascular function in systemic sclerosis.


Daniels, J., Pauling, J. D. and Eccleston, C., 2017. Behaviour change interventions for the management of Raynaud's Phenomenon: a systematic review protocol. BMJ Open, 7 (8), e017039.

Pauling, J. D., 2017. Could nailfold videocapillaroscopy usher in a new era of preventative disease-modifying therapeutic intervention in systemic sclerosis?:Prognostic value of nailfold capillaroscopy in SSc. Rheumatology, 56 (7), pp. 1053-1055.

Bissell, L.-A., Anderson, M., Burgess, M., Chakravarty, K., Coghlan, G., Dumitru, R. B., Graham, L., Ong, V., Pauling, J. D., Plein, S., Schlosshan, D., Woolfson, P. and Buch, M. H., 2017. Consensus best practice pathway of the UK Systemic Sclerosis Study group:management of cardiac disease in systemic sclerosis. Rheumatology, 56 (6), pp. 912-921.

Hamann, P., Holland, R., Hyrich, K., Pauling, J. D., Shaddick, G., Nightingale, A. and McHugh, N., 2017. Factors associated with sustained remission in rheumatoid arthritis in patients treated with anti-tumour necrosis factor (anti-TNF). Arthritis Care and Research, 69 (6), pp. 783-793.

McCarthy, E. M., Moreno-Martinez, D., Wilkinson, F. L., McHugh, N. J., Bruce, I. N., Pauling, J. D., Alexander, M. Y. and Parker, B., 2017. Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease. Neuroimage Clinical, 7, pp. 16-22.

Veale, B. J., Jablonski, R. Y., Frech, T. M. and Pauling, J. D., 2016. Orofacial manifestations of systemic sclerosis. British Dental Journal, 221 (6), pp. 305-310.

Scolnik, M., Vasta, B., Hart, D. J., Shipley, J. A., McHugh, N. J. and Pauling, J. D., 2016. Symptoms of Raynaud's phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology. Rheumatology International

Frech, T. M., Pauling, J. D., Murtaugh, M. A., Kendall, K. and Domsic, R. T., 2016. Sublingual Abnormalities in Systemic Sclerosis. JCR : Journal of Clinical Rheumatology, 22 (1), pp. 19-21.

Pauling, J. D., Shipley, J. A., Hart, D. J., McGrogan, A. and McHugh, N. J., 2015. Use of laser speckle contrast imaging to assess digital microvascular function in primary Raynaud phenomenon and systemic sclerosis:a comparison using the Raynaud condition score diary. The Journal of Rheumatology, 42 (7), pp. 1163-1168.

Gunn, J., Pauling, J.D. and McHugh, N.J., 2014. Impact of anti-centromere antibodies on pulmonary function test results in patients with systemic sclerosis without established or suspected pulmonary disease. Clinical Rheumatology, 33 (6), pp. 869-871.

Vasta, B., Flower, V., Bucciarelli-Ducci, C., Brown, S., Korendowych, E., McHugh, N.J. and Pauling, J.D., 2014. Abnormal cardiac enzymes in systemic sclerosis:A report of four patients and review of the literature. Clinical Rheumatology, 33 (3), pp. 435-438.

Pauling, J. D., 2014. Evaluating digital vascular perfusion and platelet dysfunction in Raynaud’s phenomenon and systemic sclerosis. Thesis (Doctor of Philosophy (PhD)). University of Bath.

Strickland, G., Pauling, J., Cavill, C., Shaddick, G. and McHugh, N., 2013. Mortality in systemic sclerosis-a single centre study from the UK. Clinical Rheumatology, 32 (10), pp. 1533-1539.

Pauling, J. D., O'Donnell, V. B. and McHugh, N. J., 2013. The contribution of platelets to the pathogenesis of Raynaud's phenomenon and systemic sclerosis. Platelets, 24 (7), pp. 503-515.

Strickland, G., Pauling, J., Cavill, C. and McHugh, N., 2012. Predictors of health-related quality of life and fatigue in systemic sclerosis:evaluation of the EuroQol-5D and FACIT-F assessment tools. Clinical Rheumatology, 31 (8), pp. 1215-1222.

Pauling, J.D., Shipley, J.A., Harris, N.D. and McHugh, N.J., 2012. Use of infrared thermography as an endpoint in therapeutic trials of Raynaud's phenomenon and systemic sclerosis. Clinical and Experimental Rheumatology, 30 (Supplement 71), S103-S115.

Pauling, J. D., Shipley, J. A., Raper, S., Watson, M. L., Ward, S. G., Harris, N. D. and McHugh, N. J., 2012. Comparison of infrared thermography and laser speckle contrast imaging for the dynamic assessment of digital microvascular function. Microvascular Research, 83 (2), pp. 162-167.

Pauling, J. D. and McHugh, N. J., 2012. Evaluating factors influencing screening for pulmonary hypertension in systemic sclerosis:does disparity between available guidelines influence clinical practice? Clinical Rheumatology, 31 (2), pp. 357-361.

Newton, J.L., Frith, J., Powell, D., Hackett, K., Wilton, K., Bowman, S., Price, E., Pease, C., Andrews, J., Emery, P., Hunter, J., Gupta, M., Vadivelu, S., Giles, I., Isenberg, D., Lanyon, P., Jones, A., Regan, M., Cooper, A., Moots, R., Sutcliffe, N., Bombardieri, M., Pitzalis, C., McLaren, J., Young-Min, S., Dasgupta, B., Griffiths, B., Lendrem, D., Mitchell, S., Ng, W.-F., Bacabac, E.C., Moots, R., Chadravarty, K., Lamabadusuriya, S., Bombardieri, M., Pitzalis, C., Sutcliffe, N., Gendi, N., Adeniba, R., Hamburger, J., Richards, A., Rauz, S., Brailsford, S., Logan, J., Mulherin, D., Andrews, J., Emery, P., McManus, A., Pease, C., Booth, A., Regan, M., Dimitroulas, T., Kadiki, L., Kaur, D., Kitas, G., Lloyd, M., Moore, L., Gordon, E., Lawson, C., Gupta, M., Hunter, J., Stirton, L., Ortiz, G., Price, E., Clunie, G., Rose, G., Cuckow, S., Knight, S., Symmons, D., Jones, B., Carr, A., Edgar, S., Carrozzo, M., Figuereido, F., Foggo, H., Gillespie, C., Lendrem, D., Macleod, I., Mitchell, S., Tarn, J., Jones, A., Lanyon, P., Muir, A., White, P., Young-Min, S., Pugmire, S., Vadivelu, S., Cooper, A., Watkins, M., Field, A., Kaye, S., Mewar, D., Medcalf, P., Tomlinson, P., Whiteside, D., McHugh, N., Pauling, J., James, J., Olaitan, N., Akil, M., McDermott, J., Godia, O., Coady, D., Kidd, E., Palmer, L., Dasgupta, B., Katsande, V., Long, P., Chandra, U., MacKay, K., Fedele, S., Ferenkeh-Koroma, A., Isenberg, D., Marconnell, H., Porter, S., Allcoat, P. and McLaren, J., 2012. Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjögren's syndrome. Annals of the Rheumatic Diseases, 71 (12), pp. 1973-1979.

Pauling, J. D., Flower, V., Shipley, J. A., Harris, N. D. and McHugh, N. J., 2011. Influence of the cold challenge on the discriminatory capacity of the digital distal–dorsal difference in the thermographic assessment of Raynaud's phenomenon. Microvascular Research, 82 (3), pp. 364-368.

Pauling, J., Brown, S. J., James, J., Shipley, J. A., Korendowych, E. and McHugh, N. J., 2011. Vacuum-assisted closure therapy: a novel treatment for wound healing in systemic sclerosis. Rheumatology, 50 (2), pp. 420-422.

Pauling, J. D., Flower, V. and McHugh, N., 2011. Influence of the cold challenge on the discriminatory capacity of the digital distal-dorsal thermal gradient in the thermographic assessment of Raynaud's phenomenon. Rheumatology, 50, p. 131.

Flower, V., Pauling, J. D., Shipley, J. A. and McHugh, N. J., 2010. Raynaud's phenomenon and macrocytic anaemia. BMJ, 341, c6011.

Pauling, J. D., Shipley, J. A. and McHugh, N. J., 2010. Impaired digital vascular function mimicking Raynaud's phenomenon as a complication of argon laser therapy in tuberous sclerosis. Microvascular Research, 80 (1), p. 2.

Pauling, J. D., Gunawardena, H., Coghlan, J. G., Easaw, J., Suntharalingam, J. and McHugh, N. J., 2008. Pulmonary artery hypertension as the presenting feature of systemic sclerosis sine scleroderma. Rheumatology, 47 (9), pp. 1431-1432.

This list was generated on Sat Oct 21 02:26:19 2017 IST.

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