Department of Pharmacy and Pharmacology
Senior Lecturer

5 West 2.46


Tel: +44 (0) 1225 383393 


Dr Malcolm Watson


Lung Inflammation

Inflammation plays an important role in the pathology of lung diseases including asthma and chronic obstructive pulmonary diseases. Our laboratories are carrying out a number of studies to examine the interactions between the resident cells of the lung and the substances released during immune responses, with a specific focus on the changes to airway and pulmonary cell function induced by the cytokines or lipopolysaccharide.

We are utilising a combination of cell and organ culture techniques and physiological measurements coupled with pharmacological and molecular approaches to determine the mechanisms of airway and pulmonary vascular dysfunction during inflammation. These techniques are being applied to examine TNF and IL-13 signalling in airway epithelial cells, and how these cytokines agents are able to modify the responsiveness of airway smooth muscle and vascular responsiveness.

A better understanding of the interactions between the cells and chemical mediators in the lung will enable the rational design of novel therapeutic agents for the treatment of inflammatory airway disease.


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