Department of Pharmacy and Pharmacology
 

Matt Thomas

Visiting Professor

Professor Matt Thomas

Profile 

Matt Thomas is a visiting Professor in the Department of Pharmacy and Pharmacology. Matt has a BSc in Biomolecular Science and a PhD in Immunology, both from Kings College, London.

From early academic studies in T cell biology, allergic responses and asthma, Matt progressed to a career in remodelling aspects of pulmonary drug discovery. Since 2001, he has been a member / leader of international multi-disciplinary teams in pharmaceutical research – within the Novartis Institutes for Biomedical Research (UK) until 2014 and now with AstraZeneca Respiratory, Inflammation and Autoimmunity iMed (Sweden). Matt continues to champion the synergy between academic institutions and ‘big pharma’ through numerous diverse collaborations, student co-supervision (BSc, PhD & post-doctoral), student placement initiatives, course lectureship, course examination input, invited conference presentation and peer-reviewed publication.

Research interests

Matt’s drug discovery interests span target finding, pathways investigation, pathophysiology, translational pre-clinical systems/ biomarkers and the route into patients. He currently specializes in respiratory diseases including idiopathic pulmonary fibrosis (IPF), pulmonary arterial hypertension (PAH), cystic fibrosis (CF), severe asthma and chronic obstructive pulmonary disease (COPD). More focused areas of research have been T cell:dendritic cell interactions within allergy, chemokine signalling and directed cell movement, mechanisms of enhanced pulmonary vascular tone, vascular smooth muscle cell proliferation/differentiation, tyrosine kinase inhibition in remodelling diseases, serotonin biology, the influence of micro-RNAs on remodelling pathways, aerobic capacity and metabolic dysregulation in pulmonary arterial hypertension.

Current principal areas of active research are modelling pulmonary fibrosis in 3D micro-tissue cultures and using patient-derived precision cut lung slices to better understand epithelium:matrix:fibroblast cross-talk in disease. The role/s of exosome communication in fibrotic pathogenesis is also under investigation.