Department of Pharmacy and Pharmacology

nikoletta_fotaki

Reader in Pharmaceutics

7W 2.8

Email:  n.fotaki@bath.ac.uk

Tel: +44 (0) 1225 38 6728

 

Dr Nikoletta Fotaki

Profile

Dr Nikoletta Fotaki is a UK-registered Greek Pharmacist. She graduated from the National and Kapodistrian University of Athens in Greece and she obtained a MSc in Toxicology from the University of Surrey in the UK. She completed her PhD in Biopharmaceutics-Pharmacokinetics at the School of Pharmacy of the National and Kapodistrian University of Athens in Greece. During this period she worked on various research projects. She worked as a Pharmacist in the National Organisation of Drugs in Greece (EOF) and she was a Postdoctoral Fellow in the School of Pharmacy (National and Kapodistrian University of Athens, Greece) upon completion of her Ph.D degree. After that she was offered a further postdoctoral fellowship by Roche ( New Jersey, USA).

Dr Fotaki’s research and activities are focused on the prediction of oral drug absorption, which is an area of very keen interest in the pharmaceutical world due to the increasing use of libraries to screen structures for potential activity and the need to select leads based not only on potential receptor interactions but also on the basis of ability to be absorbed orally. She is working on the development of in vitro screening tools and associated softwares for predicting oral absorption, the assessment of the impact of changes in drug substance properties and changes in the formulation process on bioavailability , animal models for predicting absorption, and in vitro-in vivo correlations/ in vitro-in vivo relations.

Publications

Grignard, E., Taylor, R., McAllister, M., Box, K. and Fotaki, N., 2017. Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies. European Journal of Pharmaceutical Sciences, 99, pp. 193-201.

Taylor, R., Box, K., Mole, J., Fotaki, N., Gringard, E. and McAllister, M., 2016. A biphasic dissolution method to mimic oral absorption from simulated animal gastrintestinal fluids. In: AAPS Annual Meeting, 2016, 2016-11-13 - 2016-11-17, Colorado Convention Center.

Lorier, M., Fotaki, N., Vázquez, M. and Fagiolino, P., 2016. Biorelevant in vitro dissolution coupled with n-octanol partition assay to predict in vivo absorption of ketoprofen after oral administration. In: AAPS Annual Meeting, 2016, 2016-11-13 - 2016-11-17, Colorado Convention Center.

Nikolettos, I., Savvidou, O., Katsibri, P. and Fotaki, N., 2016. Characterisation and drug solubility studies in Rheumatoid Arthritis and Osteoarthritis synovial fluid towards the development of in vitro disease state biorelevant media. In: AAPS Annual Meeting, 2016, 2016-11-13 - 2016-11-17, Colorado Convention Center.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2016. Correlation of drug partition kinetics to fat with drug release kinetics from fat. In: AAPS Annual Meeting, 2016, 2016-11-13 - 2016-11-17, Colorado Convention Center.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2016. Design of in vitro discriminating setups towards determination of drug partition kinetics to fat. In: AAPS Annual Meeting, 2016, 2016-11-13 - 2016-11-17, Colorado Convention Center.

Box, K., Taylor, R., Mole, J., McAllister, M., Gringard, E. and Fotaki, N., 2016. In vitro in vivo correlation of biphasic dissolution methods that mimic oral absorption from simulated rat gastrointestinal fluids. In: AAPS Annual Meeting, 2016, 2016-11-13 - 2016-11-17, Colorado Convention Center.

Lu, X., Gray, V., Fotaki, N., Han, J.-H., Krämer, J. and Stippler, E., 2016. Meeting Report: AAPS-NIFDC Joint Workshop on Dissolution Testing, Biowaiver, and Bioequivalence. Dissolution Technologies, 23 (4), pp. 46-55.

Magallanes, L., Fagiolino, P., Vázquez, M., Fotaki, N., Ibarra, M., Lorier, M., Bertola, V. and Barindelli, A., 2016. Sex-related in vitro/in vivo and PK/PD correlations after oral single dose furosemide administration. Journal of Pharmaceutical Technology and Drug Research, 5, 2.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2016. Fed-state gastric media and drug analysis techniques:Current status and points to consider. European Journal of Pharmaceutics and Biopharmaceutics, 107, pp. 234-248.

Fotaki, N. and Mercuri, A., 2016. In vitro dissolution testing for alcohol induced dose dumping:regulatory recommendations and physiological considerations. [Non-academic press]

Batchelor, H., Ernest, T., Flanagan, T., Klein, S., Turner, R., Fotaki, N. and Storey, D., 2016. Towards the development of a paediatric biopharmaceutics classification system:results of a survey of experts. International Journal of Pharmaceutics, 511 (2), pp. 1151-1157.

Lu, X., Fotaki, N., Gray, V. and Di Maso, M., 2016. In Vitro Release and Dissolution Testing for Solid Oral Dosage Formulations - Introduction to A New eCourse. [Non-academic press]

Fotaki, N., Gray, V., Krämer, J., Diaz, D., Flanagan, T. and Grove, G., 2016. Dissolution highlights from the 2015 AAPS annual meeting in Orlando. Dissolution Technologies, 23 (2), pp. 42-47.

Box, K. J., Comer, J., Taylor, R., Karki, S., Ruiz, R., Price, R. and Fotaki, N., 2016. Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration. AAPS PharmSciTech, 17 (2), pp. 245-251.

Mercuri, A., Fares, R., Bresciani, M. and Fotaki, N., 2016. An in vitro-in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages:impact of in vitro dissolution media and hydrodynamics. International Journal of Pharmaceutics, 499 (1-2), pp. 330-342.

Maharaj, A. R., Edginton, A. N. and Fotaki, N., 2016. Assessment of age-related changes in pediatric gastrointestinal solubility. Pharmaceutical Research, 33 (1), pp. 52-71.

Mencarelli, G., Jones, J., Brown, J., Timmins, P. and Fotaki, N., 2016. Age related biorelevant dissolution testing for paediatric formulations. In: 8th European Paediatric Formulation Conference (EuPFI), 2016, 2016-09-21 - 2016-09-22.

Diaz De Leon Ortega, R., D'Arcy, D. M. and Fotaki, N., 2016. Effect of biorelevant albumin concentration in simulated plasma on the solubility and stanility of Amphotericin B. In: 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Tech, 2016, 2016-04-04 - 2016-04-07.

Gringard, E., Fotaki, N., McAllister, M., Box, K. and Taylor, R., 2016. Evaluation of in vitro tests to reduce animal testing in drug toxicology studies. In: 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Tech, 2016, 2016-04-04 - 2016-04-07.

Magallanes, L., Fagiolino, P., Vázquez, M., Fotaki, N., Ibarra, M., Lorier, M., Bertola, V. and Barindelli, A., 2016. Food and sex influence on furosemide pharmacokinetics and pharmacodynamics. Current Topics in Pharmacology

Batchelor, H., Ernest, T., Flanagan, T., Klein, S., Turner, R., Fotaki, N. and Storey, D., 2016. Results of an industry survey to understand how current practice in bridging for paediatric formulations. In: 8th European Paediatric Formulation Conference (EuPFI), 2016, 2016-09-21 - 2016-09-22.

Mercuri, A., Pagliari, M., Fares, R., Baxevanis, F. and Fotaki, N., 2016. Understanding the impact of in vitro dissolution media and hydrodynamics on drug dissolution and release. In: 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Tech, 2016, 2016-04-04 - 2016-04-07.

Fotaki, N., Martin, G. P. and Gray, V., 2015. Dissolution highlights from the 2014 AAPS annual meeting in San Diego. Dissolution Technologies, 22 (3), pp. 56-58.

Taverner, A., Dondi, R., Almansour, K., Laurent, F., Owens, S.-E., Eggleston, I. M., Fotaki, N. and Mrsny, R. J., 2015. Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation. Journal of Controlled Release, 210, pp. 189-197.

Magallanes, L., Lorier, M., Ibarra, M., Vázquez, M., Fotaki, N. and Fagiolino, P., 2015. A simple pharmacokinetic model based on mean residence times to predict furosemide exposure after oral doses. International Journal of Pharmacy and Pharmaceutical Sciences, 3 (4), pp. 54-65.

Maharaj, A., Fotaki, N. and Edginton, A., 2015. Parameterization of small intestinal water volume using PBPK modeling. European Journal of Pharmaceutical Sciences, 67, pp. 55-64.

Khroyan, T. V., Wu, J., Polgar, W. E., Cami-Kobeci, G., Fotaki, N., Husbands, S. M. and Toll, L., 2015. BU08073 a buprenorphine analog with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice. British Journal of Pharmacology, 172 (2), pp. 668-680.

Taylor, R., Box, K., Mole, J., Fotaki, N., Grignard, E. and McAllister, M., 2015. A DoE study to understand partition rate in a biphasic system. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Monteiro, L., Loebenberg, R., Cotrim, P., Fotaki, N. and Bou-Cracha, N., 2015. A potential nanotechnology based drug delivery for the treatment of Leishmaniases. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Nikolettos, I., Marlow, M. and Fotaki, N., 2015. Biorelevant Dissolution Testing for the Evaluation of Drug Performance after Intra-articular Administration. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Bukhovets, A., Moustafine, R. and Fotaki, N., 2015. Biorelevant Dissolution Testing for the Evaluation of the Release Properties of Interpolymer Complexes Based on Eudragit® EPO and Eudragit® S100 Copolymers. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Magallanes, L., Fotaki, N., Bertola, V., Barindelli, A., Vazquez, M. and Fagiolino, P., 2015. Biorelevant In Vitro Dissolution Testing to Predict In Vivo Absorption of Furosemide after Oral Administration. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2015. Determination of Drug Binding Kinetics to Fat in Biorelevant Gastric Fed State Media. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Grignard, E., Fotaki, N., Taylor, R., Box, K. and McAllister, M., 2015. Evaluation of in vitro tests to reduce animal testing in drug toxicology studies. In: Pharmsci, 2015, 2015-09-07 - 2015-09-09.

Melo, K. J., Souza, N., Ferraz, H., Fotaki, N., Lobenberg, R. and Bou-Chacra, N., 2015. Formulation with Povacoat® to Prevent Aggregation of Rifampin Nanocrystal Using High-Pressure Homogenization. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2015. Impact of excipients in optimum drug extraction conditions during analysis of fed state gastric media. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Mercuri, A., Fares, R., Bresciani, M. and Fotaki, N., 2015. In Vitro/In Vivo Correlations for Nifedipine IR Capsules:The Impact of Hydrodynamics and Ethanol. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Nikolettos, I., Rosa, J., Marlow, M. and Fotaki, N., 2015. Investigating factors affecting the drug's release from parenteral suspensions. In: Pharmsci, 2015, 2015-09-07 - 2015-09-09.

Mencarelli, G., Saluja, B., Price, R. and Fotaki, N., 2015. Novel Deposition and In Vitro Dissolution Model for Orally Inhaled Drug Products. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2015. Selection of the optimum conditions for drug analysis in fed-state gastric biorelevant media. In: Pharmsci, 2015, 2015-09-07 - 2015-09-09.

Fagiolino, P., Vázquez, M., Ibarra, M., Magallanes, L., Guevara, N. and Fotaki, N., 2014. Sex- and smoke-related differences in gastrointestinal transit of cyclosporin A microemulsion capsules. European Journal of Pharmaceutical Sciences, 63, pp. 140-146.

Fotaki, N., Martin, G.P. and Salt, A., 2014. Dissolution highlights from the 2013 AAPS annual meeting in San Antonio. Dissolution Technologies, 21 (3), pp. 44-46.

Fotaki, N., Batchelor, H. and Klein, S., 2014. Paediatric oral biopharmaceutics: Key considerations and current challenges. Advanced Drug Delivery Reviews, 73, pp. 102-126.

De Matas, M., Storey, R., Fotaki, N., Timmins, P., Jones, J., Batchelor, H., Parker, A.,, Tuleu, C., Ahmed, A., Ernest, T., Coupe, A., Mohammed, A. and Jackson, A., 2014. Accelerating paediatric formulation development through smart design and predictive science. In: Pharmsci, 2014, 2014-09-08 - 2014-09-10, University of Hertfordshire.

Fotaki, N., Long, C. M., Tang, K. and Chokshi, H., 2014. Dissolution of amorphous solid dispersions:theory and practice. In: Shah, N. H., Sandhu, H. K., Choi, D. S., Chokshi, H. K. and Malick, W., eds. Amorphous Solid Dispersions. New York, U. S. A.: Springer.

Fotaki, N. and Oluwasanmi, O., 2014. Effect of glass bead size on drug dissolution in the flow through cell apparatus. In: AAPS Annual Meeting, 2014, 2014-11-02 - 2014-11-06, San Diego.

Nikolettos, I., Marlow, M. and Fotaki, N., 2014. Effect of media and hydrodynamics on release from parenteral suspensions. In: Pharmsci, 2014, 2014-09-08 - 2014-09-10, University of Hertfordshire.

Fotaki, N., Long, C. M., Cuppok-Rosiaux, Y., Marchaud, D., Garbacz, G., Lange, S. and Klein, S., 2014. Estimating in vivo drug release from a new theophylline Compritol® 888 ATO matrix formulation using appropriate biorelevant test methods. In: 41st Annual Meeting & Exposition of the Controlled Release Society (CRS), 2014, 2014-07-13 - 2014-07-16.

Fotaki, N., Malik, N., Mathews, N., Nikolettos, I. and Crist, B., 2014. Investigation on the Use of Dialysis Membrane on Drug Release from Micro Particles in Compendial Apparatus 1 and 3. In: AAPS Annual Meeting, 2014, 2014-11-02 - 2014-11-06, San Diego.

Baxevanis, F., Kuiper, J. and Fotaki, N., 2014. Strategic drug analysis in fed-state gastric biorelevant media. In: Pharmsci, 2014, 2014-09-08 - 2014-09-10, University of Hertfordshire.

Fotaki, N. and Klein, S., 2013. Mechanistic understanding of the effect of PPIs and acidic carbonated beverages on the oral absorption of itraconazole based on absorption modeling with appropriate in vitro data. Molecular Pharmaceutics, 10 (11), pp. 4016-4023.

Tomaszewska, I., Karki, S., Shur, J., Price, R. and Fotaki, N., 2013. Pharmaceutical characterisation and evaluation of cocrystals:importance of in vitro dissolution conditions and type of coformer. International Journal of Pharmaceutics, 453 (2), pp. 380-388.

Fotaki, N., Brown, W., Kochling, J., Chokshi, H., Miao, H., Tang, K. and Gray, V., 2013. Rationale for selection of dissolution media: three case studies. Dissolution Technologies, 20 (3), pp. 6-13.

Fotaki, N., Martin, G.P. and Krämer, J., 2013. Dissolution highlights from the 2012 AAPS annual meeting in Chicago. Dissolution Technologies, 20 (2), pp. 57-59.

Fotaki, N., Gray, V., Kesisoglou, F., Mayock, S., Mirza, T. and Salt, A., 2013. Survey results for in vitro-in vivo correlations (IVIVC):Critical variables for success. Dissolution Technologies, 20 (2), pp. 48-50.

Fotaki, N. and Brassine, C., 2013. Age related biorelevant dissolution testing for pediatric pellet formulations. In: 2013 AAPS Annual Meeting and Exposition, 2013-11-10 - 2013-11-14, Henry B. Gonzalez Convention Center.

Pergament, V., Schatton, W., Guldutuna, S. and Fotaki, N., 2013. Development of marine sponge collagen coated lecithin formulations for the treatment of inflammatory bowel disease. In: PharmSci, 2013, 2013-09-02 - 2013-09-04, Heriot-Watt University.

Fotaki, N., Box, K., Comer, J., Mole, J., Taylor, R., Karki, S. and Price, R., 2013. Dissolution and precipitation studies of carbamazepine cocrystals with small scale assays. In: 2013 AAPS Annual Meeting and Exposition, 2013-11-10 - 2013-11-14, Henry B. Gonzalez Convention Center.

Fotaki, N., Long, C., Tang, K. and Chokshi, H., 2013. Surface dissolution UV imaging for studying properties of a poorly soluble weak basic compound. In: 2013 AAPS Annual Meeting and Exposition, 2013-11-10 - 2013-11-14, Henry B. Gonzalez Convention Center.

Fotaki, N., Karki, S., Price, R., Chapman, A. and Lenke, J., 2013. Surface dissolution UV imaging for studying properties of pharmaceutical cocrystals for oral administration. AAPS Journal

Long, C. M., Tang, K., Chokski, H. and Fotaki, N., 2012. Investigation on the physiological relevant amount of surfactant in simulated gastric fluids for in vitro solubility and dissolution studies. In: PharmaTech 2012, 2012-11-20 - 2012-11-21.

Bittner, B., McIntyre, C., Tian, H., Tang, K., Shah, N., Phuapradit, W., Ahmed, H., Chokshi, H., Infeld, M., Fotaki, N., Ma, H., Portron, A., Jordan, P. and Schmidt, J., 2012. Phase I clinical study to select a novel oral formulation for ibandronate containing the excipient sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC). Die Pharmazie - An International Journal of Pharmaceutical Sciences, 67 (3), pp. 233-241.

Gray, V., Fotaki, N. and Martin, G. P., 2012. Dissolution highlights from the 2011 AAPS annual meeting in Washington, D. C. Dissolution Technologies, 19 (1), pp. 69-70.

Cabana Montenegro, S., Delgado-Charro, M. B. and Fotaki, N., 2012. Development and evaluation of age appropriate pellet formulations for an antiepileptic drug. In: 4th Conference of the European Paediatric Formulation Initiative (EuPFI) 2012, 2012-09-19 - 2012-09-20.

Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2012. Development of PBPK model for an amorphous oral formulation of a poorly soluble drug:importance of in vitro solubility and dissolution data. AAPS Journal

Tomaszewska, I. and Fotaki, N., 2012. Development of a PBPK model for a poorly soluble drug:importance of in vitro solubility and dissolution data. In: UK-PharmSci Meeting, 2012, 2012-09-12 - 2012-09-14.

Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2012. In vitro dissolution characterization of an amorphous formulation of a BCS class II compound. In: UK-PharmSci Meeting, 2012, 2012-09-12 - 2012-09-14.

Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2012. In vitro-in vivo correlations for an amorphous formulation of a poorly soluble compound. In: FIP Conference, 2012-10-03 - 2012-10-08.

Tomaszewska, I., Price, R. and Fotaki, N., 2012. Investigation of the mechanism of dissolution from pharmaceutical cocrystals and implications for oral administration. AAPS Journal

Box, K., Comer, J., Mole, J., Taylor, R., Karki, S., Price, R. and Fotaki, N., 2012. Small scale assays for studying dissolution and precipitation of pharmaceutical cocrystals. AAPS Journal

Fotaki, N., 2011. Flow-through cell apparatus (USP apparatus 4):Operation and features. Dissolution Technologies, 18 (4), pp. 46-49.

Martin, G. P., Fotaki, N., Salt, A. D. and Gray, V. A., 2011. 2010 Pharmaceutical Sciences World Congress Provides Dissolution Programming with an International Flavor. Dissolution Technologies, 18 (2), pp. 38-42.

Tomaszewska, I., Price, R. and Fotaki, N., 2011. Development for pharmaceutical cocrystals. In: PharmSci APSGB Meeting, 2011-01-26.

Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2011. Dissolution testing for amorphous formulations:Effect of media and hydrodynamics. AAPS Journal, 13 (S2).

Tomaszewska, I., Price, R. and Fotaki, N., 2011. Pharmaceutical cocrystals:Effect of media and coformer on dissolution. AAPS Journal, 13 (S2).

Pergament, V., Schatton, W. and Fotaki, N., 2011. Study of release properties from marine sponge collagen coated formulations. AAPS Journal, 13 (S2).

Fotaki, N. and Vertzoni, M., 2010. Biorelevant dissolution methods and their applications in in vitroin vivo correlations for oralformulations. The Open Drug Delivery Journal, 4 (1), pp. 2-13.

Fotaki, N., 2010. Controlled release formulations of BSC class I compounds. AAPS Journal, 12 (S2).

Edginton, A. M. and Fotaki, N., 2010. Oral drug absorption in pediatric populations. In: Dressman, J. B. and Reppas, C., eds. Oral Drug Absorption: Prediction and Assessment, 2nd Edition.Vol. 193. New York: Informa Healthcare, pp. 108-126.

Fotaki, N., Aivaliotis, A., Butler, J., Dressman, J., Fischbach, M., Hempenstall, J., Klein, S. and Reppas, C., 2009. A comparative study of different release apparatus in generating in vitro–in vivo correlations for extended release formulations. European Journal of Pharmaceutics and Biopharmaceutics, 73 (1), pp. 115-120.

Fotaki, N., Warren, K., Irish, N. and Haden Tebb, A., 2009. Development of in vitro-in vivo correlations (IVIVCs) for controlled release formulations of BSC Class I compounds. In: 2nd PharmSciFair, 2009-06-08 - 2009-06-12.

Wang, Q. X., Fotaki, N. and Mao, Y., 2009. Biorelevant dissolution: Methodology and application in drug development. Dissolution Technologies, 16 (3), pp. 6-12.

Fotaki, N., 2009. Pros and cons of methods used for the prediction of oral drug absorption. Expert Review of Clinical Pharmacology, 2 (2), pp. 195-208.

This list was generated on Fri Oct 20 19:28:50 2017 IST.

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