Dr Nikoletta Fotaki
Profile
Dr Nikoletta Fotaki is a UK-registered Greek Pharmacist. She graduated from the National and Kapodistrian University of Athens in Greece and she obtained a MSc in Toxicology from the University of Surrey in the UK. She completed her PhD in Biopharmaceutics-Pharmacokinetics at the School of Pharmacy of the National and Kapodistrian University of Athens in Greece. During this period she worked on various research projects. She worked as a Pharmacist in the National Organisation of Drugs in Greece (EOF) and she was a Postdoctoral Fellow in the School of Pharmacy (National and Kapodistrian University of Athens, Greece) upon completion of her Ph.D degree. After that she was offered a further postdoctoral fellowship by Roche ( New Jersey, USA).
Dr Fotaki’s research and activities are focused on the prediction of oral drug absorption, which is an area of very keen interest in the pharmaceutical world due to the increasing use of libraries to screen structures for potential activity and the need to select leads based not only on potential receptor interactions but also on the basis of ability to be absorbed orally. She is working on the development of in vitro screening tools and associated softwares for predicting oral absorption, the assessment of the impact of changes in drug substance properties and changes in the formulation process on bioavailability , animal models for predicting absorption, and in vitro-in vivo correlations/ in vitro-in vivo relations.
Publications
Fotaki, N., Brown, W., Kochling, J., Chokshi, H., Miao, H., Tang, K. and Gray, V., 2013. Forthcoming. Rationale for Selection of Dissolution Media: Three Case Studies. Dissolution Technologies
Tomaszewska, I., Karki, S., Shur, J., Price, R. and Fotaki, N., 2013. Forthcoming. Pharmaceutical characterisation and evaluation of cocrystals: Importance of in vitro dissolution conditions and type of coformer. International Journal of Pharmaceutics
Fotaki, N., Martin, G.P. and Krämer, J., 2013. Dissolution highlights from the 2012 AAPS annual meeting in Chicago. Dissolution Technologies, 20 (2), pp. 57-59.
Fotaki, N., Gray, V., Kesisoglou, F., Mayock, S., Mirza, T. and Salt, A., 2013. Survey results for in vitro-in vivo correlations (IVIVC) : critical variables for success. Dissolution Technologies, 20 (2), pp. 48-50.
Fotaki, N., Karki, S., Price, R., Chapman, A. and Lenke, J., 2013. Forthcoming. Surface dissolution UV imaging for studying properties of pharmaceutical cocrystals for oral administration. AAPS Journal
Long, C. M., Tang, K., Chokski, H. and Fotaki, N., 2012. Investigation on the physiological relevant amount of surfactant in simulated gastric fluids for in vitro solubility and dissolution studies. In: PharmaTech 2012, 2012-11-20 - 2012-11-21, Kuala Lumpur.
Bittner, B., McIntyre, C., Tian, H., Tang, K., Shah, N., Phuapradit, W., Ahmed, H., Chokshi, H., Infeld, M., Fotaki, N., Ma, H., Portron, A., Jordan, P. and Schmidt, J., 2012. Phase I clinical study to select a novel oral formulation for ibandronate containing the excipient sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC). Die Pharmazie - An International Journal of Pharmaceutical Sciences, 67 (3), pp. 233-241.
Cabana Montenegro, S., Delgado-Charro, M. B. and Fotaki, N., 2012. Development and evaluation of age appropriate pellet formulations for an antiepileptic drug. In: 4th Conference of the European Paediatric Formulation Initiative (EuPFI) 2012, 2012-09-19 - 2012-09-20, Prague.
Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2012. Forthcoming. Development of PBPK model for an amorphous oral formulation of a poorly soluble drug : importance of in vitro solubility and dissolution data. AAPS Journal
Tomaszewska, I. and Fotaki, N., 2012. Development of a PBPK model for a poorly soluble drug : importance of in vitro solubility and dissolution data. In: UK-PharmSci Meeting, 2012, 2012-09-12 - 2012-09-14, Nottingham.
Gray, V., Fotaki, N. and Martin, G. P., 2012. Dissolution highlights from the 2011 AAPS annual meeting in Washington, D. C. Dissolution Technologies, 19 (1), pp. 69-70.
Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2012. In vitro dissolution characterization of an amorphous formulation of a BCS class II compound. In: UK-PharmSci Meeting, 2012, 2012-09-12 - 2012-09-14, Nottingham.
Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2012. In vitro-in vivo correlations for an amorphous formulation of a poorly soluble compound. In: FIP Conference, 2012-10-03 - 2012-10-08, Amsterdam.
Tomaszewska, I., Price, R. and Fotaki, N., 2012. Forthcoming. Investigation of the mechanism of dissolution from pharmaceutical cocrystals and implications for oral administration. AAPS Journal
Box, K., Comer, J., Mole, J., Taylor, R., Karki, S., Price, R. and Fotaki, N., 2012. Forthcoming. Small scale assays for studying dissolution and precipitation of pharmaceutical cocrystals. AAPS Journal
Fotaki, N., 2011. Flow-through cell apparatus (USP apparatus 4): Operation and features. Dissolution Technologies, 18 (4), pp. 46-49.
Martin, G. P., Fotaki, N., Salt, A. D. and Gray, V. A., 2011. 2010 Pharmaceutical Sciences World Congress Provides Dissolution Programming with an International Flavor. Dissolution Technologies, 18 (2), pp. 38-42.
Tomaszewska, I., Price, R. and Fotaki, N., 2011. Development for pharmaceutical cocrystals. In: PharmSci APSGB Meeting, 2011-01-26, Nottingham.
Long, C., Tang, K., Chokshi, H. and Fotaki, N., 2011. Dissolution testing for amorphous formulations : effect of media and hydrodynamics. AAPS Journal, 13 (S2).
Tomaszewska, I., Price, R. and Fotaki, N., 2011. Pharmaceutical cocrystals : effect of media and coformer on dissolution. AAPS Journal, 13 (S2).
Pergament, V., Schatton, W. and Fotaki, N., 2011. Study of release properties from marine sponge collagen coated formulations. AAPS Journal, 13 (S2).
Fotaki, N. and Vertzoni, M., 2010. Biorelevant dissolution methods and their applications in in vitro- in vivo correlations for oral formulations. The Open Drug Delivery Journal, 4 (2), pp. 2-13.
Fotaki, N., 2010. Controlled release formulations of BSC class I compounds. AAPS Journal, 12 (S2).
Edginton, A. M. and Fotaki, N., 2010. Oral drug absorption in pediatric populations. In: Dressman, J. B. and Reppas, C., eds. Oral Drug Absorption: Prediction and Assessment, 2nd Edition. Vol. 193. New York: Informa Healthcare, pp. 108-126.
Fotaki, N., Aivaliotis, A., Butler, J., Dressman, J., Fischbach, M., Hempenstall, J., Klein, S. and Reppas, C., 2009. A comparative study of different release apparatus in generating in vitro–in vivo correlations for extended release formulations. European Journal of Pharmaceutics and Biopharmaceutics, 73 (1), pp. 115-120.
Fotaki, N., Warren, K., Irish, N. and Haden Tebb, A., 2009. Development of in vitro-in vivo correlations (IVIVCs) for controlled release formulations of BSC Class I compounds. In: 2nd PharmSciFair, 2009-06-08 - 2009-06-12, Nice.
Wang, Q. X., Fotaki, N. and Mao, Y., 2009. Biorelevant dissolution: Methodology and application in drug development. Dissolution Technologies, 16 (3), pp. 6-12.
Fotaki, N., 2009. Pros and cons of methods used for the prediction of oral drug absorption. Expert Review of Clinical Pharmacology, 2 (2), pp. 195-208.
