Department of Pharmacy and Pharmacology

sillhouette

Senior Lecturer in Pharmaceutics

5 West - 2.26

Email: P.DeBank@bath.ac.uk

Tel: +44 (0) 1225 384017 

De Bank group web pages

 

Dr Paul De Bank 

Profile

Our research focuses on tissue engineering and regenerative medicine, either replacing diseased or damaged tissues with a fully functional construct or promoting the repair of tissue in situ. This is a highly multidisciplinary area and we use a combination of cell biology, materials science and synthetic chemistry to develop strategies to improve cell-based constructs and tissue repair by manipulating cell-cell and cell-biomaterial interactions, especially for musculoskeletal and neuronal tissue targets.

A number of key challenges still exist if complex engineered tissues are to be clinically successful, including the formation of blood vessel networks within the constructs and the ability to direct cell positioning and growth in three dimensions. We are addressing these problems using novel experimental approaches such as “caged” chemical functional groups for the selective modification of cell scaffolds with bioactive molecules, potentially allowing 3D control over the positioning of cues for cell adhesion and growth. We are also developing new bioreactor-based 3D culture systems to promote the growth of thick tissues with an in-built system of natural and artificial vessels. In the body, cells tend to be within 100-200 µm of a blood vessel to ensure an effective supply of oxygen and nutrients plus removal of waste. In engineered tissues, this is not the case and so developing tissues are prone to necrosis if steps are not taken to improve mass transport of fluids.

Our laboratory is part of the University’s Centre for Regenerative Medicine and our research has received funding from the BBSRC, the EPSRC, the MRC, the Royal Society, the EU and the University of Bath.

Publications

Rediguieri, C., De Bank, P., Zanin, M. H. A., Leo, P., Cerize, N. N. P., de Oliveira, A. M. and Pinto, T., 2017. The effect of ozone gas sterilization on the properties and cell compatibility of electrospun polycaprolactone scaffolds. Journal of Biomaterials Science, Polymer Edition

Fortunato, T., De Bank, P. and Pula, G., 2017. Vascular Regenerative Surgery: Promised Land for Tissue Engineers? International Journal of Stem Cell Research and Transplantation, 5 (2), pp. 268-276.

Awasthi, R., Kulkarni, G., Ramana, M. V., Pinto, T., Kikuchi, I. S., Ghisleni, D., de Souza Braga, M., De Bank, P. and Dua, K., 2017. Dual crosslinked pectin–alginate network as sustained release hydrophilic matrix for repaglinide. International Journal of Biological Macromolecules, 97, pp. 721-732.

Fortunato, T., Beltrami, C., Emanueli, C., De Bank, P. and Pula, G., 2016. Platelet lysate gel and endothelial progenitors stimulate microvascular network formation in vitro: tissue engineering implications. Scientific Reports, 6, 25326.

Rediguieri, C. F., de Jesus Andreoli Pinto, T., Bou-Chacra, N. A., Galante, R., Lima Barros de Araújo, G., do Nascimento Pedrosa, T., Maria-Engler, S. S., De Bank, P. A. and , P. D. B., 2016. Ozone gas as a benign sterilization treatment for PLGA nanofibre scaffolds. Tissue Engineering part C Methods, 22 (4), pp. 338-347.

Alhusein, N., Blagbrough, I. S., Beeton, M. L., Bolhuis, A. and De Bank, P. A., 2016. Electrospun Zein/PCL Fibrous Matrices Release Tetracycline in a Controlled Manner, Killing Staphylococcus aureus Both in Biofilms and Ex Vivo on Pig Skin, and are Compatible with Human Skin Cells. Pharmaceutical Research, 33 (1), pp. 237-246.

Fortunato, T., De Bank, P. and Pula, G., 2015. Platelet Lysate Gel and Endothelial Progenitors Stimulate Microvascular Network Formation In Vitro: Implications for Regenerative Medicine. In: 3rd SW Regional Regenerative Medicine Meeting, 2015-09-22 - 2015-09-22, DOuble Tree Hilton.

Alhusein, N., Blagbrough, I., Bolhuis, A. and De Bank, P., 2015. Controlled Release of Tetracycline From Electrospun Micro/Nanofibrous Zein/PCL Blended Mats: In Vitro and Ex Vivo Testing. In: Controlled Release Society Annual Meeting, 2015-07-26 - 2015-07-29.

Li, R., De Bank, P. and Mrsny, R., 2015. Polymeric nanocarrier delivery of protein through the epithelial cells. In: Controlled Release Society Annual Meeting, 2015-07-26 - 2015-07-29.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2015. Silk fibroin/gelatin blended materials as osteogenic scaffolds for tissue engineering. In: Tissue and Cell Engineering Society 2015 Conference, 2015-07-19 - 2015-07-21.

Blagbrough, I., Alhusein, N. and De Bank, P., 2015. Zein-PCL Electrospun Triple-Layered Nanofibre Matrices For Localised Controlled Delivery of Tetracycline. In: Controlled Release Society Annual Meeting, 2015-07-26 - 2015-07-29.

Fortunato, T., De Bank, P. and Pula, G., 2015. Human Platelet Lysate Gel as a Substrate for Isolation and Delivery of Endothelial Colony-Forming Cells. In: Joint 28th European Society for Microcirculation (ESM) 8th European Vascular Biology Organisation (EVBO) Meeting, 2015-06-03 - 2015-06-06.

Pula, G., Fortunato, T. and De Bank, P., 2015. Human platelet lysate gel (HPLG) supports and stimulates endothelial progenitor cell-driven vasculogenesis. In: XXV Congress of the International Society on Thrombosis and Haemostasis, 2015-06-20 - 2015-06-25.

Alhusein, N., De Bank, P. and Blagbrough, I., 2015. Polycaprolactone Electrospun Nanofibers for Controlled Drug Delivery. In: Mishra, M., ed. The Encyclopedia of Biomedical Polymers and Polymeric Biomaterials.Vol. 7. 1 ed. CRC Press, pp. 5239-5249.

Rediguieri, C., De Bank, P., Araújo, G. and Pinto, T., 2015. Exploring Methods for Controlling the Quality of Random and Aligned Electrospun Nanofibers. In: Society for Biomaterials Annual Meeting and Exposition, 2015-04-15 - 2015-04-18.

Li, R., De Bank, P. and Mrsny, R., 2015. Polymeric nanocarrier transport across Caco-2 cell monolayers in vitro. In: Nanotechnologies in Drug Delivery Congress, 2015-04-27 - 2015-04-28.

Meneghello, G., Storm, M. P., Chaudhuri, J. B., De Bank, P. A. and Ellis, M. J., 2015. An investigation into the stability of commercial versus MG63-derived hepatocyte growth factor under flow cultivation conditions. Biotechnology Letters, 37 (3), pp. 725-731.

Pula, G., Fortunato, T. and De Bank, P., 2015. Human platelet lysate gel (HPLG) supports and stimulates endothelial progenitor cell-driven vasculogenesis. Journal of Thrombosis and Haemostasis, 13 (S2), p. 271.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2015. Silk fibroin/gelatin blended materials as osteogenic scaffolds for tissue engineering. European Cells and Materials, 29 (S3), p. 78.

O'Donovan, L. and De Bank, P., 2014. A hydrazide-anchored dendron scaffold for chemoselective ligation strategies. Organic and Biomolecular Chemistry, 12 (37), pp. 7290-7296.

Wright, B., De Bank, P. A., Luetchford, K., Acosta, F. R. and Connon, C. J., 2014. Oxidised alginate hydrogels as niche environments for corneal epithelial cells. Journal of Biomedical Materials Research, Part A, 102 (10), pp. 3393-3400.

Alhusein, N., De Bank, P., Blagbrough, I. and Bolhuis, A., 2014. Controlled release of tetracycline hydrochloride from electrospun micro/nanofibrous mats: in vitro and ex vivo testing. In: PharmSci APSGB Meeting, 2011-01-26.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2014. Silk-based microparticles as an osteogenic scaffold for tissue engineering. In: Tissue and Cell Engineering Society 2014 Conference, 2014-07-02 - 2014-07-04.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2014. Novel Silk Fibroin/Gelatin Microparticles as Building Blocks for Tissue Engineering. In: Cardiff Stem Cell Symposium, 2014-01-29 - 2014-01-29.

De Bank, P., 2014. Novel Treatment to Help Fight Drug-resistant Bacteria. [Non-academic press]

Luetchford, K., Chaudhuri, J. and De Bank, P., 2014. Silk-based microparticles as an osteogenic scaffold for tissue engineering. European Cells and Materials, 28 (S4), p. 62.

Alhusein, N., De Bank, P. A., Blagbrough, I. S. and Bolhuis, A., 2013. Killing bacteria within biofilms by sustained release of tetracycline from triple-layered electrospun micro/nanofibre matrices of polycaprolactone and poly(ethylene-co-vinyl acetate). Drug Delivery and Translational Research, 3 (6), pp. 531-541.

Alhusein, N., Blagbrough, I. S. and De Bank, P. A., 2013. Zein/polycaprolactone electrospun matrices for localised controlled delivery of tetracycline. Drug Delivery and Translational Research, 3 (6), pp. 542-550.

Ciupa, A., De Bank, P. A. and Caggiano, L., 2013. Multicellular aggregation of maltol-modified cells triggered by Fe3+ ions. Chemical Communications, 49 (86), pp. 10148-10150.

Alhusein, N., De Bank, P., Blagbrough, I. and Bolhuis, A., 2013. Antibiotic Electrospun Micro/Nanofibrous Wound Dressing Formulations - In Vitro Testing Against Biofilms. In: PharmSci APSGB Meeting, 2011-01-26.

Alhusein, N., Stone, L., Wu, V., Rassam, I., Blagbrough, I. and De Bank, P., 2013. Controlled Release of Tetracycline Hydrochloride from an Electrospun Triple-Layered Zein Nanofibre Matrix. In: PharmSci APSGB Meeting, 2011-01-26.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2013. Microparticles as building blocks for tissue engineering. In: Tissue and Cell Engineering Society 2013 Conference, 2013-07-23 - 2013-07-25.

Ciupa, A., De Bank, P. A., Mahon, M. F., Wood, P. J. and Caggiano, L., 2013. Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines. MedChemComm, 4 (6), pp. 956-961.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2013. Microparticles as building blocks for tissue engineering. European Cells and Materials, 26 (S7), p. 69.

Alhusein, N., Blagbrough, I. S. and De Bank, P. A., 2012. Electrospun matrices for localised controlled drug delivery: release of tetracycline hydrochloride from layers of polycaprolactone and poly(ethylene-co-vinyl acetate). Drug Delivery and Translational Research, 2 (6), pp. 477-488.

Ciupa, A., Mahon, M., De Bank, P. and Caggiano, L., 2012. Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd2+ and Zn2+ in MeCN. Organic and Biomolecular Chemistry, 10 (44), pp. 8753-8757.

O'Donovan, L. and De Bank, P. A., 2012. A photocleavable linker for the chemoselective functionalization of biomaterials. Journal of Materials Chemistry, 22 (41), pp. 21878-21884.

O'Donovan, E. and De Bank, P., 2012. Design and Evaluation of a Caged Aldehyde for the Chemoselective Patterning of Biomaterial Scaffolds with Bioactive Molecules. In: 2nd SW Regional Regenerative Medicine Meeting, 2012-09-20 - 2012-09-21, Arnos Manor Hotel.

Bischof, J. and De Bank, P., 2012. Evaluation of Silk/Gelatin Blends as Substrates for Muscle Tissue Engineering. In: 2nd SW Regional Regenerative Medicine Meeting, 2012-09-20 - 2012-09-21, Arnos Manor Hotel.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2012. Processing Silk-Based Naturally Derived Materials for Three-Dimensional Cell Culture and Tissue Engineering Applications. In: 2nd SW Regional Regenerative Medicine Meeting, 2012-09-20 - 2012-09-21, Arnos Manor Hotel.

Alhusein, N., Blagbrough, I. and De Bank, P., 2012. Release of Antibiotics from Electrospun Polymeric Nanofibrous Layers. In: PharmSci APSGB Meeting, 2011-01-26.

O'Donovan, E. and De Bank, P., 2012. A Novel Caged Carbonyl for Biomaterial Modification and Cell Patterning. In: Tissue and Cell Engineering Society 2012 Conference, 2012-07-04 - 2012-07-06.

Alhusein, N., De Bank, P. and Blagbrough, I., 2012. An Electrospun Triple-Layered PCL-PEVA-PCL Nanofibre Matrix Controlled Release Drug Delivery System. In: Controlled Release Society Annual Meeting, 2015-07-26 - 2015-07-29.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2012. Processing Silk-Based Naturally Derived Materials for Three-Dimensional Cell Culture and Tissue Engineering Applications. In: Tissue and Cell Engineering Society 2012 Conference, 2012-07-04 - 2012-07-06.

Alhusein, N., Blagbrough, I. and De Bank, P., 2012. Controlled Release of Tetracycline Hydrochloride From an Electrospun Triple Layered PCL-PEVA-PCL Nanofibre Matrix. In: World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2012-03-19 - 2012-03-22.

Luetchford, K., Chaudhuri, J. and De Bank, P., 2012. Processing Silk-Based Naturally Derived Materials for Three-Dimensional Cell Culture and Tissue Engineering Applications. European Cells and Materials, 23 (S4), p. 70.

O'Donovan, E. and De Bank, P., 2011. A Novel Caged Carbonyl for Biomaterial Modification and Cell Patterning. In: 1st UK-Israel Regenerative Medicine Conference, 2011-11-22 - 2011-11-23, Ben-Gurion University of the Negev.

De Bank, P., 2011. A Novel Caged Carbonyl for Biomaterial Modification and Cell Patterning. In: Conférences Européenes du Groupement des Pharmacochimistes de L'Arc Atlantique (GP2A), 2006-09-07 - 2006-09-08.

Kraemer, M., Chaudhuri, J., Ellis, M. and De Bank, P., 2011. Poly-L-lysine-PLGA Nanofibres as a Conducive Scaffold for Neurite Outgrowth from Neuronal Cells. In: Inaugural SW Regional Regenerative Medicine Meeting, 2011-09-12 - 2011-09-13, Wills Hall, Bristol.

O'Donovan, E. and De Bank, P., 2011. A Novel Caged Carbonyl for Biomaterial Modification and Cell Patterning. In: Tissue and Cell Engineering Society 2011 Conference, 2011-07-19 - 2011-07-21.

Kraemer, M., Chaudhuri, J., Ellis, M. and De Bank, P., 2011. Promotion of Neurite Outgrowth via Incorporation of Poly-L-lysine into Aligned PLGA Nanofibre Scaffolds. In: Tissue and Cell Engineering Society 2011 Conference, 2011-07-19 - 2011-07-21.

O'Donovan, E. and De Bank, P., 2011. A Novel Caged Carbonyl for Biomaterial Modification and Cell Patterning. European Cells and Materials, 22 (S3), p. 52.

Kraemer, M., Chaudhuri, J., De Bank, P. and Ellis, M., 2011. Aligned Neurite Outgrowth on Electrospun PLGA Nanofibres. European Cells and Materials, 22 (S2), p. 59.

Kraemer, M., Chaudhuri, J., Ellis, M. and De Bank, P., 2011. Promotion of Neurite Outgrowth via Incorporation of Poly-L-lysine into Aligned PLGA Nanofibre Scaffolds. European Cells and Materials, 22 (S3), p. 53.

Kraemer, M., Chaudhuri, J., De Bank, P. and Ellis, M., 2010. Aligned Neurite Outgrowth on Electrospun PLGA Nanofibres. In: Tissue and Cell Engineering Society 2010 Conference, 2010-07-28 - 2010-07-30.

De Bank, P., Jones, M. and Ellis, M., 2009. Polymeric scaffolds for regenerative medicine. In: Mattiasson, B., Kumar, A. and Galaev, I. Y., eds. Macroporous Polymers: Production Properties and Biotechnological/Biomedical Applications. CRC Press, pp. 467-495.

Meneghello, G., Parker, D. J., Ainsworth, B. J., Perera, S. P., Chaudhuri, J. B., Ellis, M. J. and De Bank, P. A., 2009. Fabrication and characterization of poly(lactic-co-glycolic acid)/polyvinyl alcohol blended hollow fibre membranes for tissue engineering applications. Journal of Membrane Science, 344 (1-2), pp. 55-61.

Meneghello, G., Ainsworth, B., Perera, S., Chaudhuri, J., Ellis, M. and De Bank, P., 2008. Effect of Polyvinyl Alcohol and Sodium Hypochlorite on Porosity and Hydrophilicity of PLGA Hollow Fibre Membrane Scaffolds. In: TERMIS: tissue engineering and regenerative medicine international society, 2007-01-01.

Gribbon, C. and De Bank, P., 2008. A Novel Method to Engineer Large ex vivo Neo-Tissue. In: Tissue and Cell Engineering Society Annual Conference, 2014-07-02 - 2014-07-04, University of Newcastle.

Meneghello, G., Ainsworth, B., De Bank, P., Ellis, M. and Chaudhuri, J., 2008. Effect of Polyvinyl Alcohol and Sodium Hypochlorite on Porosity and Mechanical Properties of PLGA Hollow Fibre Membrane Scaffolds. In: Tissue and Cell Engineering Society Annual Conference, 2014-07-02 - 2014-07-04, University of Newcastle.

Meneghello, G., Ainsworth, B., De Bank, P., Ellis, M. J. and Chaudhuri, J., 2008. Effect of polyvinyl alcohol and sodium hypochlorite on porosity and mechanical properties of PLGA hollow fibre membrane scaffolds. European Cells and Materials, 16 (S3), p. 82.

Gribbon, C. and De Bank, P., 2008. Cell/Microparticle Aggregates – A Novel Method to Engineer Large ex vivo Neo-Tissue. European Cells and Materials, 16 (S3), p. 56.

This list was generated on Tue Oct 17 12:23:39 2017 IST.

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