Department of Pharmacy and Pharmacology
richard_guy

Professor of Pharmaceutical Sciences

7 West -3.13

Email:  R.H.Guy@bath.ac.uk

 Tel: +44 (0) 1225 384901 

 

Current group members

[co]-supervised PhD students, postdoctoral research associates, technical staff:

  • Duygu Celebi
  • Wing-Sing Chiu
  • James Clarke
  • Luis Rodrigo Contreras-Rojas
  • Sarah Cordery
  • Bertrand Dupont
  • Kit Frederiksen
  • Hazel Garvie-Cook
  • Leila Leal
  • Alistair Taverner
  • Simon Vanstone

Prof Richard Guy 

Profile

Richard Guy received an M.A. in Chemistry from Oxford University, and his Ph.D. in Pharmaceutical Chemistry from the University of London. He has held academic posts at the University of California, San Francisco and the University of Geneva. In 2004, he joined the University of Bath as Professor of Pharmaceutical Sciences, and he currently serves as the Chair of the Research Committee of the Department of Pharmacy & Pharmacology. Dr. Guy is an elected fellow of the Academy of Pharmaceutical Scientists, Great Britain, the Royal Society of Chemistry, the Controlled Release Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science.

Research

Dr. Guy's research focuses on skin barrier function characterization, transdermal drug delivery, enhancement of percutaneous absorption, iontophoresis, noninvasive biosensing, and the prediction and assessment of skin penetration and topical bioavailability. Dr. Guy has published 350+ peer-reviewed articles and over 70 book chapters. He has co-authored one book and co-edited 7 others. He is also co-inventor of 12 patents. Specific ongoing projects include: measurement of the skin's biomechanical properties at the nanoscale using atomic force microscopy; exploring in vitro - in vivo correlations to faciltate the determination of of topical drug product bioavailability and bioequivalence; the potential of polymeric film-forming systems as sustained release platforms for topical drugs; determination of the disposition of drug and formulation excipients (including nanoparticles) post-application to the skin using coherent Raman scattering and confocal microscopy; development of an integrated iontophoretic delivery system for buprenorphine and naltrexone to treat polydrug abuse; examination of a graphene-based biosensor for noninvasive, transdermal glucose monitoring; quantification of dermal absorption from pesticide residues from treated plant surfaces; and derivation and evaluation of predictive models of percutaneous penetration for pharmaceutical and cosmetic 'actives', and for potentially toxic chemicals, which come into contact with skin.

Publications

Wiedersberg, S. and Guy, R. H., 2014. Transdermal drug delivery : 30 + years of war and still fighting! Journal of Controlled Release, 190, pp. 150-156.

Yang, Q. and Guy, R.H., 2014. Forthcoming. Characterisation of Skin Barrier Function Using Bioengineering and Biophysical Techniques. Pharmaceutical Research

Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M. and Bailey, C. P., 2014. A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology, 19 (4), pp. 575-586.

Delgado-Charro, M. B. and Guy, R. H., 2014. Effective use of transdermal drug delivery in children. Advanced Drug Delivery Reviews, 73, pp. 63-82.

Thitilertdecha, P., Guy, R.H. and Rowan, M.G., 2014. Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin. Journal of Ethnopharmacology, 154 (2), pp. 400-407.

Guy, R.H., Kuma, H. and Nakanishi, M., 2014. Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation. European Journal of Dermatology, 24 (3), pp. 365-371.

Belsey, N. A., Garrett, N. L., Contreras-Rojas, L. R., Pickup-Gerlaugh, A. J., Price, G. J., Moger, J. and Guy, R. H., 2014. Evaluation of drug delivery to intact and porated skin by coherent Raman scattering and fluorescence microscopies. Journal of Controlled Release, 174 (28), pp. 37-42.

Güngör, S., Delgado-Charro, M. B., Masini-Etévé, V., Potts, R. O. and Guy, R. H., 2013. Transdermal flux predictions for selected selective oestrogen receptor modulators (SERMs) : Comparison with experimental results. Journal of Controlled Release, 172 (3), pp. 601-606.

Ridd, M., Guy, R., Ball, N., Roberts, A. and Williams, H., 2013. Products in "Bounty bags" potentially harm newborn skin. BMJ, 346 (7913), f3895.

Benzeval, I., Bowen, C. R., Guy, R. H. and Delgado-Charro, M. B., 2013. Effects of iontophoresis, hydration, and permeation enhancers on human nail plate: Infrared and impedance spectroscopy assessment. Pharmaceutical Research, 30 (6), pp. 1652-1662.

Beard, J. D., Guy, R. H. and Gordeev, S. N., 2013. Mechanical tomography of human corneocytes with a nanoneedle. Journal Of Investigative Dermatology, 133 (6), pp. 1565-1571.

Gelfuso, G. M., Gratieri, T., Delgado-Charro, M. B., Guy, R. H. and Vianna Lopez, R. F., 2013. Iontophoresis-targeted, follicular delivery of minoxidil sulfate for the treatment of alopecia. Journal of Pharmaceutical Sciences, 102 (5), pp. 1488-1494.

Cordery, S. F., Taverner, A., Ridzwan, I. E., Guy, R. H., Delgado-Charro, M. B., Husbands, S. M. and Bailey, C. P., 2013. A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology

Russell, L.M. and Guy, R.H., 2012. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies : Proof-of-concept with acyclovir formulations. Pharmaceutical Research, 29 (12), pp. 3362-3372.

Djabri, A., Guy, R. H. and Delgado-Charro, M. B., 2012. Transdermal iontophoresis of ranitidine: An opportunity in paediatric drug therapy. International Journal of Pharmaceutics, 435 (1), pp. 27-32.

Mohammed, D., Yang, Q., Guy, R.H., Matts, P.J., Hadgraft, J. and Lane, M.E., 2012. Comparison of gravimetric and spectroscopic approaches to quantify stratum corneum removed by tape-stripping. European Journal of Pharmaceutics and Biopharmaceutics, 82 (1), pp. 171-174.

Russell, L. M. and Guy, R. H., 2012. Novel imaging method to quantify stratum corneum in dermatopharmacokinetic studies. Pharmaceutical Research, 29 (9), pp. 2389-2397.

Campbell, C. S. J., Contreras-Rojas, L. R., Delgado-Charro, B. and Guy, R. H., 2012. Objective assessment of nanoparticle disposition in mammalian skin after topical exposure. Journal of Controlled Release, 162 (1), pp. 201-207.

Djabri, A., Guy, R. H. and Delgado-Charro, M. B., 2012. Passive and iontophoretic transdermal delivery of phenobarbital: implications in paediatric therapy. International Journal of Pharmaceutics, 435 (1), pp. 76-82.

Mitragotri, S., Anissimov, Y. G., Bunge, A. L., Frasch, H. F., Guy, R. H., Hadgraft, J., Kasting, G. B., Lane, M. E. and Roberts, M. S., 2011. Mathematical models of skin permeability: An overview. International Journal of Pharmaceutics, 418 (1), pp. 115-129.

Saar, B. G., Contreras-Rojas, L. R., Xie, X. S. and Guy, R. H., 2011. Imaging drug delivery to skin with stimulated Raman scattering microscopy. Molecular Pharmaceutics, 8 (3), pp. 969-975.

Belsey, N. A., Cordery, S. F., Bunge, A. L. and Guy, R. H., 2011. Assessment of dermal exposure to pesticide residues during re-entry. Environmental Science & Technology, 45 (10), pp. 4609-4615.

Guy, R. H. and Szoka, F. C., 2011. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Physical Chemistry Chemical Physics, 13 (12), pp. 5346-5352.

Beard, J. D., Gordeev, S. N. and Guy, R. H., 2011. AFM nanotools for surgery of biological Cells. Journal of Physics: Conference Series, 286 (1), 012003.

Watkinson, R. M., Guy, R. H., Oliveira, G., Hadgraft, J. and Lane, M. E., 2011. Optimisation of Cosolvent Concentration for Topical Drug Delivery III - Influence of Lipophilic Vehicles on Ibuprofen Permeation. Skin Pharmacology and Physiology, 24 (1), pp. 22-26.

Taverner, A., Cordery, S., Husbands, S. M., Guy, R. H., Delgado-Charro, B. M. and Bailey, C. P., 2011. Transdermal delivery of a buprenorphine/naltrexone combination for the treatment of polydrug abuse. Pharmacological Reports, 63 (1), p. 257.

Yang, Q., Cordery, S. and Guy, R. H., 2010. Application of biophysics and bioengineering to the assessment of barrier function. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1249-1250.

Güngör, S., Delgado-Charro, M. B., Ruiz-Perez, B., Schubert, W., Isom, P., Moslem, P., Patane, M. A. and Guy, R. H., 2010. Trans-scleral iontophoretic delivery of low molecular weight therapeutics. Journal of Controlled Release, 147 (2), pp. 225-231.

Sylvestre, J. P., Bouissou, C., Guy, R. H. and Delgado-Charro, M. B., 2010. Extraction and quantification of amino acids in human stratum corneum in vivo. British Journal of Dermatology, 163 (3), pp. 458-465.

Hathout, R. M., Woodman, T. J., Mansour, S., Mortada, N. D., Geneidi, A. S. and Guy, R. H., 2010. Microemulsion formulations for the transdermal delivery of testosterone. European Journal of Pharmaceutical Sciences, 40 (3), pp. 188-196.

Wu, X., Landfester, K., Musyanovych, A. and Guy, R. H., 2010. Disposition of charged nanoparticles after their topical application to the skin. Skin Pharmacology and Physiology, 23 (3), pp. 117-123.

Tsang, M. and Guy, R. H., 2010. Effect of Aqueous Cream BP on human stratum corneum in-vivo. British Journal of Dermatology, 163 (5), pp. 954-958.

Thitilertdecha, P., Akkarasereenont, P., Laohapand, T., Rowan, M. G. and Guy, R. H., 2010. Formulation optimisation for the topical delivery of active agents in traditional medicines. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1272-1273.

Guy, R. H., 2010. Predicting the rate and extent of fragrance chemical absorption into and through the skin. Chemical Research in Toxicology, 23 (5), pp. 864-870.

Guy, R. H., 2010. Transdermal drug delivery. In: Schafer-Korting, M., ed. Drug Delivery. Vol. 197. 197 ed. Springer, pp. 399-410.

Hathout, R. M., Mansour, S., Mortada, N. D., Geneidi, A. S. and Guy, R. H., 2010. Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function. Molecular Pharmaceutics, 7 (4), pp. 1266-1273.

Bouissou, C. C., Sylvestre, J.-P., Guy, R. H. and Delgado-Charro, M. B., 2009. Reverse iontophoresis of amino acids: identification and separation of stratum corneum and subdermal sources in vitro. Pharmaceutical Research, 26 (12), pp. 2630-2638.

Wu, X. and Guy, R. H., 2009. Applications of nanoparticles in topical drug delivery and in cosmetics. Journal of Drug Delivery Science and Technology, 19 (6), pp. 371-384.

Wu, X., Price, G. J. and Guy, R. H., 2009. Disposition of nanoparticles and an associated lipophilic permeant following topical application to the skin. Molecular Pharmaceutics, 6 (5), pp. 1441-1448.

Wu, X., Griffin, P., Price, G. J. and Guy, R. H., 2009. Preparation and in vitro evaluation of topical formulations based on polystyrene-poly-2-hydroxyl methacrylate nanoparticles. Molecular Pharmaceutics, 6 (5), pp. 1449-1456.

Wu, X., Biatry, B., Cazeneuve, C. and Guy, R. H., 2009. Drug delivery to the skin From sub-micron polymeric particle formulations: Influence of particle size and polymer hydrophobicity. Pharmaceutical Research, 26 (8), pp. 1995-2001.

Cork, M. J., Danby, S. G., Vasilopoulos, Y., Hadgraft, J., Lane, M. E., Moustafa, M., Guy, R. H., Macgowan, A. L., Tazi-Ahnini, R. and Ward, S. J., 2009. Epidermal barrier dysfunction in atopic dermatitis. Journal Of Investigative Dermatology, 129 (8), pp. 1892-1908.

Nicoli, S., Bunge, A. L., Delgado-Charro, M. B. and Guy, R. H., 2009. Dermatopharmacokinetics: factors influencing drug clearance from the stratum corneum. Pharmaceutical Research, 26 (4), pp. 865-871.

Wiedersberg, S., Leopold, C. S. and Guy, R. H., 2009. Dermatopharmacokinetics of betamethasone 17-valerate: Influence of formulation viscosity and skin surface cleaning procedure. European Journal of Pharmaceutics and Biopharmaceutics, 71 (2), pp. 362-366.

N’Dri-Stempfer, B., Navidi, W. C., Guy, R. H. and Bunge, A. L., 2009. Improved bioequivalence assessment of topical dermatological drug products using dermatopharmacokinetics. Pharmaceutical Research, 26 (2), pp. 316-328.

Watkinson, R. M., Herkenne, C., Guy, R. H., Hadgraft, J., Oliveira, G. and Lane, M. E., 2009. Influence of ethanol on the solubility, ionization and permeation characteristics of ibuprofen in silicone and human skin. Skin Pharmacology and Physiology, 22 (1), pp. 15-21.

Grégoire, S., Ribaud, C., Benech, F., Meunier, J. R., Garrigues-Mazert, A. and Guy, R. H., 2009. Prediction of chemical absorption into and through the skin from cosmetic and dermatological formulations. British Journal of Dermatology, 160 (1), pp. 80-91.

Yow, H. N., Wu, X., Routh, A. F. and Guy, R. H., 2009. Dye diffusion from microcapsules with different shell thickness into mammalian skin. European Journal of Pharmaceutics and Biopharmaceutics, 72 (1), pp. 62-68.

Wiedersberg, S., Leopold, C. S. and Guy, R. H., 2009. Effects of Various Vehicles on Skin Hydration in vivo. Skin Pharmacology and Physiology, 22 (3), pp. 128-130.

Sieg, A., Jeanneret, F., Fathi, M., Hochstrasser, D., Rudaz, S., Veuthey, J. L., Guy, R. H. and Delgado-Charro, M. B., 2009. Extraction of amino acids by reverse iontophoresis in vivo. European Journal of Pharmaceutics and Biopharmaceutics, 72 (1), pp. 226-231.

Mehier-Humbert, S., Bettinger, T., Yan, F. and Guy, R. H., 2009. Influence of polymer adjuvants on the ultrasound-mediated transfection of cells in culture. European Journal of Pharmaceutics and Biopharmaceutics, 72 (3), pp. 567-573.

Russell, L. M. and Guy, R. H., 2009. Measurement and prediction of the rate and extent of drug delivery into and through the skin. Expert Opinion on Drug Delivery, 6 (4), pp. 355-369.

Watkinson, R. M., Guy, R. H., Hadgraft, J. and Lane, M. E., 2009. Optimisation of cosolvent concentration for topical drug delivery - II: Influence of propylene glycol on Ibuprofen permeation. Skin Pharmacology and Physiology, 22 (4), pp. 225-230.

Wiedersberg, S., Naik, A., Leopold, C. S. and Guy, R. H., 2009. Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability. British Journal of Dermatology, 160 (3), pp. 676-686.

Sylvestre, J., Diaz-Marin, C., Delgado-Charro, M. and Guy, R., 2008. Iontophoresis of dexamethasone phosphate: Competition with chloride ions. Journal of Controlled Release, 131 (1), pp. 41-46.

Sylvestre, J. -P., Guy, R. H. and Delgado-Charro, M. B., 2008. In vitro optimization of Dexamethasone Phosphate delivery by iontophoresis. Physical Therapy, 88 (10), pp. 1177-1185.

Dias, M., Naik, A., Guy, R. H., Hadgraft, J. and Lane, M. E., 2008. In vivo infrared spectroscopy studies of alkanol effects on human skin. European Journal of Pharmaceutics and Biopharmaceutics, 69 (3), pp. 1171-1175.

Wascotte, V., Rozet, E., Salvaterra, A., Hubert, P., Jadoul, M., Guy, R. H. and Préat, V., 2008. Non-invasive diagnosis and monitoring of chronic kidney disease by reverse iontophoresis of urea in vivo. European Journal of Pharmaceutics and Biopharmaceutics, 69 (3), pp. 1077-1082.

N'Dri-Stempfer, B., Navidi, W. C., Guy, R. H. and Bunge, A. L., 2008. Optimizing metrics for the assessment of bioequivalence between topical drug products. Pharmaceutical Research, 25 (7), pp. 1621-1630.

Wiedersberg, S., Leopold, C. S. and Guy, R. H., 2008. Bioavailability and bioequivalence of topical glucocorticoids. European Journal of Pharmaceutics and Biopharmaceutics, 68 (3), pp. 453-466.

Trichard, L., Delgado-Charro, M. B., Guy, R. H., Fattal, E. and Bochot, A., 2008. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug. Pharmaceutical Research, 25 (2), pp. 435-440.

Herkenne, C., Naik, A., Kalia, Y. N., Hadgraft, J. and Guy, R. H., 2008. Effect of propylene glycol on ibuprofen absorption into human skin in vivo. Journal of Pharmaceutical Sciences, 97 (1), pp. 185-197.

Herkenne, C., Alberti, I., Naik, A., Kalia, Y. N., Mathy, F. X., Préat, V. and Guy, R. H., 2008. In vivo methods for the assessment of topical drug bioavailability. Pharmaceutical Research, 25 (1), pp. 87-103.

Sieg, A., Jeanneret, F., Fathi, M., Hochstrasser, D., Rudaz, S., Veuthey, J. L., Guy, R. H. and Delgado-Charro, M. B., 2008. Extraction of amino acids by reverse iontophoresis: Simulation of therapeutic monitoring in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 70 (3), pp. 908-913.

This list was generated on Fri Oct 24 12:51:18 2014 IST.

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