Department of Pharmacy and Pharmacology

robert_price

Professor in Pharmaceutics

5 West - 2.27

Email: r.price@bath.ac.uk

Tel: +44 (0) 1225 383644 

 

Prof Robert Price 

Profile

PharmaceuticalSurface Science

Our main research focus is in the application of advanced surface analytical technologies for the exploration of the physical and chemical factors which govern particulate interactions in pharmaceutical dosage forms. We are also focussed on the development of novel particle engineering technologies for pharmaceutical systems.

Particulate Interactions in Inhalation Systems

The characteristic properties of dry powder and suspension based pressurised metered dose inhaler formulations are governed by a fine balance of the cohesive (drug-drug) and adhesive (drug-excipient, drug-device) interactions. Our research interests involve characterising the relationship between short-range and long-range interfacial forces with aerosol behaviour. The refinement of the colloidal probe AFM technique, led by the pharmaceutical surface science research group, has provided a novel preformulation tool for characterising the physico-chemical properties of active pharmaceutical ingredients within solid-state formulation preparations and a means of determining the key attributes which control and enhance their behaviour.

Surface Stability of Processed Particles

The uncontrollable nature of secondary processing (e.g. micronisation, milling) of active pharmaceutical ingredients has been shown to lead to significant inter and intra batch variations in formulation performance and the potential source of instability within powder based formulations. The shear forces applied inevitably lead to localised formation of amorphous disorder on the surfaces of the particles. Although the concentration may be low, for high surface area to volume particles it may significantly affect their physico-chemical properties.

To investigate their possible effects we have utilised the AFM in its conventional imaging mode together with an auxiliary phase imaging technique to elucidate variations in the physico-mechanical properties of mechanical processed particles. This novel approach has provided direct characterisation of surface induced disorder of processed particle and real-time visualisation of the surface stability induced by variations in temperature and/or moisture.

Particle Engineering Processing

Although constructive processes for the production of solid drug particles within an optimum particle size range are available, there remains a need to develop novel particle engineering technologies with a greater control of the physico-chemical properties while maintaining high throughput, low cost and industrial scalability. Our approach has utilised the information available at the single particle level to develop several novel technologies in the area of particle engineering. This includes the novel production of spherical crystalline particles through a combination of solution atomisation and controlled crystallisation by ultrasonication (SACS). The SACS process has been utilised as a single step (continuous or batch) operation which can control and modify the size, shape, while influencing the surface roughness and polymorphic form of drug crystals in a single droplet to particle (SDP) operation.

Publications

Shur, J., Price, R., Lewis, D., Young, P. M., Woollam, G., Singh, D. and Edge, S., 2016. From single excipients to dual excipient platforms in dry powder inhaler products. International Journal of Pharmaceutics, 514 (2), pp. 374-383.

Marshall, L. J., Oguejiofor, W., Price, R. and Shur, J., 2016. Investigation of the enhanced antimicrobial activity of combination dry powder inhaler formulations of lactoferrin. International Journal of Pharmaceutics, 514 (2), pp. 399-406.

Tobyn, M. and Price, R., 2016. John Staniforth—An appreciation:the non-conformist nonconformist. International Journal of Pharmaceutics, 514 (2), pp. 333-334.

Dawson, M., Soro, V., Dymock, D., Price, R., Griffiths, H., Dudding, T., Sandy, J. R. and Ireland, A. J., 2016. Microbiological assessment of aerosol generated during debond of fixed orthodontic appliances. American Journal of Orthodontics and Dentofacial Orthopedics, 150 (5), pp. 831-838.

Box, K. J., Comer, J., Taylor, R., Karki, S., Ruiz, R., Price, R. and Fotaki, N., 2016. Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration. AAPS PharmSciTech, 17 (2), pp. 245-251.

Shur, J., Saluja, B., Lee, S., Tibbatts, J. and Price, R., 2015. Effect of device design and formulation on the in vitro comparability for multi-unit dose dry powder inhalers. AAPS Journal, 17 (5), pp. 1105-1116.

Kinnunen, H., Hebbink, G., Peters, H., Huck, D., Makein, L. and Price, R., 2015. Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition. International Journal of Pharmaceutics, 478 (1), pp. 53-59.

Mencarelli, G., Saluja, B., Price, R. and Fotaki, N., 2015. Novel Deposition and In Vitro Dissolution Model for Orally Inhaled Drug Products. In: AAPS Annual Meeting, 2015, 2015-10-25 - 2015-10-29.

Depasquale, R., Lee, S. L., Saluja, B., Shur, J. and Price, R., 2014. The influence of secondary processing on the structural relaxation dynamics of fluticasone propionate. AAPS PharmSciTech, 16 (3), pp. 589-600.

Kinnunen, H., Hebbink, G., Peters, H., Shur, J. and Price, R., 2014. An Investigation into the Effect of Fine Lactose Particles on the Fluidization Behaviour and Aerosolization Performance of Carrier-Based Dry Powder Inhaler Formulations. AAPS PharmSciTech, 15 (4), pp. 898-909.

Kinnunen, H., Hebbink, G., Peters, H., Shur, J. and Price, R., 2014. Defining the critical material attributes of lactose monohydrate in carrier based dry powder inhaler formulations using artificial neural networks. AAPS PharmSciTech, 15 (4), pp. 1009-1020.

Tomaszewska, I., Karki, S., Shur, J., Price, R. and Fotaki, N., 2013. Pharmaceutical characterisation and evaluation of cocrystals:importance of in vitro dissolution conditions and type of coformer. International Journal of Pharmaceutics, 453 (2), pp. 380-388.

Shur, J., Pitchayajittipong, C., Rogueda, P. and Price, R., 2013. Effect of processing history on the surface interfacial properties of budesonide in carrier-based dry-powder inhalers. Therapeutic Delivery, 4 (8), pp. 925-937.

Fotaki, N., Box, K., Comer, J., Mole, J., Taylor, R., Karki, S. and Price, R., 2013. Dissolution and precipitation studies of carbamazepine cocrystals with small scale assays. In: 2013 AAPS Annual Meeting and Exposition, 2013-11-10 - 2013-11-14, Henry B. Gonzalez Convention Center.

Shur, J., Lee, S., Adams, W., Lionberger, R., Tibbatts, J. and Price, R., 2012. Effect of device design on the in vitro performance and comparability for capsule-based dry powder inhalers. AAPS Journal, 14 (4), pp. 667-676.

Shur, J., Kubavat, H. A., Ruecroft, G., Hipkiss, D. and Price, R., 2012. Influence of crystal form of ipratropium bromide on micronisation and aerosolisation behaviour in dry powder inhaler formulations. Journal of Pharmacy and Pharmacology, 64 (9), pp. 1326-1336.

Kubavat, H. A., Shur, J., Ruecroft, G., Hipkiss, D. and Price, R., 2012. Influence of primary crystallisation conditions on the mechanical and interfacial properties of micronised budesonide for dry powder inhalation. International Journal of Pharmaceutics, 430 (1-2), pp. 26-33.

Kubavat, H. A., Shur, J., Ruecroft, G., Hipkiss, D. and Price, R., 2012. Investigation into the influence of primary crystallization conditions on the mechanical properties and secondary processing behaviour of fluticasone propionate for carrier based dry powder inhaler formulations. Pharmaceutical Research, 29 (4), pp. 994-1006.

Shur, J. and Price, R., 2012. Advanced microscopy techniques to assess solid-state properties of inhalation medicines. Advanced Drug Delivery Reviews, 64 (4), pp. 369-382.

de Boer, A. H., Chan, H. K. and Price, R., 2012. A critical view on lactose-based drug formulation and device studies for dry powder inhalation: Which are relevant and what interactions to expect? Advanced Drug Delivery Reviews, 64 (3), pp. 257-274.

Rogueda, P. G. A., Price, R., Smith, T., Young, P. M. and Traini, D., 2011. Particle synergy and aerosol performance in non-aqueous liquid of two combinations metered dose inhalation formulations: An AFM and Raman investigation. Journal of Colloid and Interface Science, 361 (2), pp. 649-655.

Ireland, A. J., Wilson, A. A., Blythe, L., Johnston, N. J., Price, R. and Sandy, J. R., 2011. Particulate production during orthodontic production laboratory procedures. Journal of Exposure Science and Environmental Epidemiology, 21 (5), pp. 536-540.

Shur, J. and Price, R., 2011. The influence of crystals, particles and powders on the performance of dry powder inhalers. In: 2011 AIChE Annual Meeting, Conference Proceedings. AIChE.

Kinnunen, H., Shur, J., Hebbink, G., Muresan, A. S. and Price, R., 2010. Lactose fluidisation properties and their relationship to dry powder inhaler performance. Journal of Pharmacy and Pharmacology, 62 (10), pp. 1342-1343.

Pitchayajittipong, C., Price, R., Shur, J., Kaerger, J. S. and Edge, S., 2010. Characterisation and functionality of inhalation anhydrous lactose. International Journal of Pharmaceutics, 390 (2), pp. 134-141.

Pitchayajittipong, C., Shur, J. and Price, R., 2009. Engineering of crystalline combination inhalation particles of a long-acting beta2-agonist and a corticosteroid. Pharmaceutical Research, 26 (12), pp. 2657-2666.

Begat, P., Morton, D. A. V., Shur, J., Kippax, P., Staniforth, J. N. and Price, R., 2009. The role of force control agents in high-dose dry powder inhaler formulations. Journal of Pharmaceutical Sciences, 98 (8), pp. 2770-2783.

Shur, J., Nevell, T. G., Ewen, R. J., Price, R., Smith, A., Barbu, E., Conway, J. H., Carroll, M. P., Shute, J. K. and Smith, J. R., 2008. Cospray-dried unfractionated heparin with L-leucine as a dry powder inhaler mucolytic for cystic fibrosis therapy. Journal of Pharmaceutical Sciences, 97 (11), pp. 4857-68.

Edge, S., Mueller, S., Price, R. and Shur, J., 2008. Factors affecting defining the quality and functionality of excipients used in the manufacture of dry powder inhaler products. Drug Development and Industrial Pharmacy, 34 (9), pp. 966-73.

Hooton, J. C., Jones, M., Harris, H., Shur, J. and Price, R., 2008. The influence of crystal habit on the prediction of dry powder inhalation formulation performance using the cohesive-adhesive force balance approach. Drug Development and Industrial Pharmacy, 34 (9), pp. 974-83.

Shur, J., Harris, H., Jones, M., Kaerger, J. S. and Price, R., 2008. The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations. Pharmaceutical Research, 25 (7), pp. 1631-1640.

Tuley, R., Shrimpton, J., Jones, M., Price, R., Palmer, M. and Prime, D., 2008. Experimental observations of dry powder inhaler dose fluidisation. International Journal of Pharmaceutics, 358 (1-2), pp. 238-247.

Jones, M., Harris, H., Hooton, J. C., Shur, J., King, G. S., Mathoulin, C. A., Nichol, K., Smith, T. L., Dawson, M. L., Ferrie, A. R. and Price, R., 2008. An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive-adhesive force balances. European Journal of Pharmaceutics and Biopharmaceutics, 69 (2), pp. 496-507.

Jones, M., Hooton, J. C., Dawson, M. L., Ferrie, A. R. and Price, R., 2008. An investigation into the dispersion mechanisms of ternary dry powder inhaler formulations by the quantification of interparticulate forces. Pharmaceutical Research, 25 (2), pp. 337-348.

Young, P. M. and Price, R., 2008. Comparative measurements of pressurised metered dose inhaler (pMDI) stem displacement. Drug Development and Industrial Pharmacy, 34 (1), pp. 90-94.

Day, C. J., Price, R., Sandy, J. R. and Ireland, A. J., 2008. Inhalation of aerosols produced during the removal of fixed orthodontic appliances: A comparison of 4 enamel cleanup methods. American Journal of Orthodontics and Dentofacial Orthopedics, 133 (1).

Jones, M., Young, P. M., Traini, D., Shur, J., Edge, S. and Price, R., 2008. The use of atomic force microscopy to study the conditioning of micronised budesonide. International Journal of Pharmaceutics, 357 (1-2), pp. 314-317.

This list was generated on Fri Oct 20 21:16:14 2017 IST.

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