Department of Pharmacy and Pharmacology

sarah_bailey

Senior Lecturer

5 West - 2.40

Email:  S.Bailey@bath.ac.uk

Tel: +44 (0) 1225 386842 

 

Dr Sarah Bailey 

Profile

Depression is estimated to affect 1 in 6 UK adults at any one time. Vulnerability to depression and anxiety is thought to arise from the influence of multiple genes acting together with environmental factors. However, the molecular basis of these diseases is not well understood. Depression and anxiety are complex behaviours involving multiple brain regions and as such can only be studied in a whole behaving organism. In my laboratory we use a combination of behavioural, electrophysiological and molecular techniques to understand the molecular mechanisms involved in anxiety and depression. The behavioural tasks used are non-invasive and use the innate behaviour of mice to assess novelty-induced changes in exploratory behaviour. Current research focuses on three inter-related aspects of depression.

Kappa opioid receptors

Dynorphin is a neuropeptide, that acts at kappa opioid receptors (KOR), and has been implicated in drug addiction and depression. Both prodynorphin, the precursor for a number of dynorphin peptides, and KOR expression is high in brain regions involved in emotional control and stress responses. KOR agonists produce dysphoric responses in humans and aversive responses in rodents. KOR antagonists on the other hand have potential utility as antidepressants and anxiolytics. In collaboration with Prof Husband’s group, we are examining the role of KOR in stress-responsiveness and developing novel KOR ligands.

Stress and adolescent depression

Major depression in adolescent populations is increasingly common. Stress is a major precipitating factor in depression and we have been investigating differences in stress-responsiveness in adult and juvenile animals. The hypothalamic pituitary axis (HPA) has been found to be hyperactive in many adult depressed patients, but the absence of hypercortisolaemia is a defining feature of adolescent depression and suggests that HPA hyperactivity does not play a key role in its aetiology. These observations suggest that the molecular substrates underlying depression in adolescents are quite different to adults (funded by the Medical Research Council).

Neuroinflammation and depression

Following a bacterial or viral infection, people experience changes in mood, appetite and interest in their environment that resemble depression. These symptoms are mediated by chemicals called cytokines that initiate inflammation as part of the body’s normal response to infection. In animal studies, exposure to an inflammatory challenge causes a systemic inflammation but also neuroinflammation, characterized by activated brain microglial cells that release cytokines. This has led to the idea that cytokines can trigger major depression. We are investigating the role of the inflammasome – a protein complex required for cytokine activation – in the brain, in response to inflammatory challenge using a combination of biochemical measures and animal studies (funded by Medical Research Council Industrial CASE PhD studentship with Janssen Pharmaceutica).

More information on neuroscience research at the University of Bath.

Further information on "The Art of the Brain" a sci-art collaborative public engagement project.

Publications

Almatroudi, A. M. I., Ostovar, M., Bailey, C., Husbands, S. and Bailey, S., 2017. Forthcoming. Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed kappa/mu opioid receptor antagonist properties, in mice. British Journal of Pharmacology

Ma, Q., Wonnacott, S., Bailey, S. and Bailey, C., 2017. Forthcoming. Gender differences in kappa opioid receptor activated brain networks implicated in the response to stress and drugs of abuse. Journal of Psychopharmacology, 31 (8), A132.

Lalji, H., Almatroudi, A. M. I., Bailey, C. and Bailey, S., 2017. Forthcoming. Investigating the effects of gender on anxiety related behaviour evoked by kappa opioid receptor activation in the elevated plus maze. Journal of Psychopharmacology, 31 (8), A21.

Wickens, R. A., Ver Donck, L., Mackenzie, A. B. and Bailey, S. J., 2017. Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome. Behavioural Brain Research

Bailey, S., Neil, J. and Moran, P., 2017. Forthcoming. Pharmacology of cognition: a panacea for neuropsychiatric disease? British Journal of Pharmacology

Bailey, S. J., Almatroudi, A. and Kouris, A., 2017. Tianeptine: An atypical antidepressant with multimodal pharmacology. Current Psychopharmacology, 6 (2).

Lilley, E., Bailey, S. and Robinson, E., 2017. Using animals in research? It's time to refine! [Non-academic press]

Sadler, A. M. and Bailey, S. J., 2016. Repeated daily restraint stress induces adaptive behavioural changes in both adult and juvenile mice. Physiology and Behavior, 167, pp. 313-323.

Ma, Q., Wonnacott, S., Bailey, S. and Bailey, C., 2016. Investigating the roles of kappa opioid receptors in neurochemical changes caused by stress and drugs of abuse. pA2Online

Jackson, M., Wickens, R., Bailey, S. and Mackenzie, A., 2016. The profile of P2X7 receptor expression and properties in polarized primary mouse microglia cultures. Journal of Psychopharmacology, 30 (Abstract Supplement ), A98.

Bailey, S., 2015. What does the Concordat on Openness on Animal Research mean for the British Pharmacological Society and its members? [Non-academic press]

Bailey, S., 2015. A Single Compound Alternative to a Buprenorphine/Naltrexone Combination, a functional kappa opioid receptor antagonist, produces antidepressant-like effects in mice. Journal of Psychopharmacology, 29 (8 (Abstract Suppleme), A22.

Sadler, A. and Bailey, S., 2015. Chronic restraint stress increases depression-related behaviour in the sucrose preference test in juvenile and adult mice. Journal of Psychopharmacology, 29 (8 (Abstract Suppleme), A02.

Wickens, R., Ver Donck, L., Mackenzie, A. and Bailey, S., 2015. The effect of housing conditions on lipopolysaccharide-induced depressive-like behaviour in mice. Journal of Psychopharmacology, 29 (8 (Abstract Suppleme), A08.

Almatroudi, A., Husbands, S. M., Bailey, C. P. and Bailey, S. J., 2015. Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice. Journal of Psychopharmacology, 29 (7), pp. 812-821.

Bailey, S., Cadman, L., Stevens, E., Laughton, F. and Shermer, D., 2015. Bringing public engagement into the undergraduate pharmacology curriculum:a cross-departmental initiative. In: Pharmacology 2015, 2015-12-15 - 2015-12-17.

Wickens, R., Ver Donck, L., Bailey, S. and Mackenzie, A., 2015. Primary microglia isolated from neonatal mice provide a model for the study of NLRP3 inflammasome and the effect of long-term hypoxia. In: Society for Neuroscience 2015, 2015-10-17 - 2015-10-21, Chicago.

Bailey, S., Almatroudi, A. M. I., Bailey, C. and Husbands, S., 2015. The antidepressant-like effects of BU10119, a novel kappa opioid receptor antagonist, in the novelty-induced hypophagia task in mice. In: Society for Neuroscience 2015, 2015-10-17 - 2015-10-21, Chicago.

Wickens, R., Ver Donck, L., Mackenzie, A. and Bailey, S. J., 2014. Acute And Chronic Lipopolysaccharide Induces Sickness But Fails To Produce A Depressive-Like Behaviour In Mice. Journal of Psychopharmacology, 28 (8), A107.

Almatroudi, A., Husbands, S. M., Bailey, C. P. and Bailey, S. J., 2014. Combination Treatment With Buprenorphine/Naltrexone, A Functional Kappa Opioid Receptor Antagonist, Produces Antidepressant-Like Effects In Mice. Journal of Psychopharmacology, 28 (8), A101.

Sadler, A. and Bailey, S. J., 2014. Evaluating gender differences in behaviour in the elevated plus maze in cd-1 and C57BL/6 mice. Journal of Psychopharmacology, 28 (8), A59.

Sadler, A. and Bailey, S. J., 2014. The effect of chronic restraint stress on depression-related behaviour in juvenile and adult C57BL/6 mice. Journal of Psychopharmacology, 28 (8), A103.

Casal-Dominguez, J. J., Furkert, D., Ostovar, M., Teintang, L., Clarke, M. J., Traynor, J. R., Husbands, S. M. and Bailey, S. J., 2014. Characterization of BU09059:A novel potent selective κ-receptor antagonist. ACS Chemical Neuroscience, 5 (3), pp. 177-184.

Sadler, A. and Bailey, S., 2014. Differential gene expression of components of the hypothalamic-pituitary adrenal axis signalling in juvenile and adult mice. In: Society for Neuroscience, 2014-11-15.

Bailey, S., Almatroudi, A. M. I., Bailey, C. and Husbands, S., 2014. The antidepressant-like effects of combination buprenorphine/naltrexone in the novelty-induced hypophagia task in mice. In: Society for Neuroscience, 2014-11-15.

Sadler, A. M. and Bailey, S. J., 2013. Validation of a refined technique for taking repeated blood samples from juvenile and adult mice. Laboratory Animals, 47 (4), pp. 316-319.

Casal-Dominguez, J. J., Clark, M., Traynor, J. R., Husbands, S. M. and Bailey, S. J., 2013. In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor. Journal of Psychopharmacology, 27 (2), pp. 192-202.

Almatroudi, A., Husbands, S. M., Bailey, C. P. and Bailey, S. J., 2013. Establishing the combination of buprenorphine and naltrexone as a functional kappa opioid receptor antagonist in mice. Proceedings of the British Pharmacological Society

Wickens, R. A., Ver Donck, L., Bailey, S. J. and Mackenzie, A. B., 2013. Lipopolysaccharide regulation of the NLRP3 inflammasome and proIL-1β under normoxic versus hypoxic conditions in cultured (BV-2) mouse microglia. Proceedings of the British Pharmacological Society, 11 (3).

Sadler, A. and Bailey, S., 2013. The effect of chronic restraint stress on anxiety-related behaviour in the elevated plus maze. Journal of Psychopharmacology, 27 (8), A17.

Bailey, S., Casal-Dominguez, J. and Husbands, S. M., 2012. Antidepressant effects of novel kappa-opioid receptor antagonists in the forced swim test. Journal of Psychopharmacology, 26 (8), A16.

Drew, C. J. G., O'Reilly, K. C., Lane, M. A. and Bailey, S. J., 2011. Chronic administration of 13-cis-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei. Neuroscience, 172, pp. 66-73.

Bailey, S. J., Casal-Dominguez, J. J. and Husbands, S. M., 2011. Anxiolytic effects of novel kappa-opioid receptor antagonists in the elevated plus maze. Journal of Psychopharmacology, 25 (8), A76.

Bailey, S. J., Casal-Dominguez, J. J., Bradbury, F. A., Traynor, J. R. and Husbands, S. M., 2010. In vivo characterisation of 5'-amino and amidino-alkyl,naltrindole derivatives at the kappa-opioid receptor. Journal of Psychopharmacology, 24 (Supplement 3), A42.

Bailey, S. J. and McCaffery, P. J., 2010. Vulnerability of the brain to neuropsychiatric disorders resulting from abnormal thyroid hormone or vitamin D homeostasis. In: Ritsner, M., ed. Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Netherlands: Springer, pp. 105-133.

Trent, S., Drew, C. J. G., Mitchell, P. J. and Bailey, S. J., 2009. Chronic treatment with 13-cis-retinoic acid changes aggressive behaviours in the resident-intruder paradigm in rats. European Neuropsychopharmacology, 19 (12), pp. 876-886.

O'Reilly, K. C., Shumake, J., Bailey, S. J., Gonzalez-Lima, F. and Lane, M. A., 2009. Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice. European Journal of Pharmacology, 605 (1-3), pp. 68-77.

Bailey, S. J. and McCaffery, P. J., 2009. Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. In: Ritsner, M. S., ed. The Handbook of Neuropsychiatric Biomarkers, Endophenotypes, and Genes. Volume III: Metabolic and Peripheral Biomarkers.Vol. 3. Netherlands: Springer, pp. 171-189.

O'Reilly, K., Bailey, S. J. and Lane, M. A., 2008. Retinoid-mediated regulation of mood: Possible cellular mechanisms. Experimental Biology and Medicine, 233 (3), pp. 251-258.

This list was generated on Tue Sep 26 03:47:37 2017 IST.

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