Department of Pharmacy and Pharmacology
tim_woodman

Senior NMR Spectroscopist

Dept of Pharmacy and Pharmacology

Email:T.Woodman@bath.ac.uk

Tel: +44 (0) 1225 386778

 

Tim Woodman

Profile

Bio

  • BSc Hons (1st) Inorganic Chemistry, University of Warwick 1994
  • PhD Inorganic Chemistry, University of Warwick 1998
  • Royal Society Visiting Fellow, Auckland University, New Zealand 1998-1999
  • Post Doctoral Research Officer, University of Leeds, UK, 1999-2000
  • Post Doctoral Research Officer, University of East Anglia, UK, 2000-2005
  • NMR Spectroscopist, University of Bath, UK, 2005 -

Research Interests

  • The role of alpha methyl acyl CoA racemase (AMACR/P504S) in prostate cancer. AMACR is an enzyme that is over-expressed in all cases of prostate cancer, and is currently of interest both as a better marker for the disease than the current prostate specific antigen (PSA) test and also as a potential target for inhibition by drug molecules. With Dr Matthew Lloyd, our research group of two PhD students is exploring the molecular biology of AMACR and attempting to identify high-throughput screening methods that will allow the isolation of potential inhibitors for this enzyme.
  • Use of diffusion ordered NMR spectroscopy (DOSY) and PCA to characterise complex mixtures. DOSY can be applied to complex mixtures to enable the identification of individual compounds with the population. PCA is a technique where large amounts of data are reduced to a set of more simple components, providing much information on how similar (or different) further samples are from these components. Projects involving these techniques include the characterization of seized drug samples and the properties and origins of wines and whiskies.  

Publications

Lloyd, Matthew, 2017. Methods (amacr). US20170176436 A1, 22 June 2017.

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2017. A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate. Chemical Communications, 53 (37), pp. 5087-5090.

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2017. A convenient colorimetric assay for α-methylacyl-CoA racemase (AMACR; P504S) and testing of inhibitors. In: 1st International Cancer Research @Bath symposium, 2017-04-20 - 2017-04-21, University of Bath.

Petrova, Y., Mattan, H., Lee, G. L., Jevglevskis, M., Woodman, T. and Lloyd, M., 2017. High-Throughput Screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S). In: 1st International Cancer Research @Bath symposium, 2017-04-20 - 2017-04-21, University of Bath.

McKeown, P., Brown-Humes, J., Davidson, M. G., Mahon, M. F., Woodman, T. J. and Jones, M., 2017. Ligands and complexes based on piperidine and their exploitation of the ring opening polymerisation of rac-lactide. Dalton Transactions, 46 (15), pp. 5048-5057.

Lloyd, Matthew, 2016. Methods (AMACR). EP3102694 A1, 14 December 2016.

Jevglevskis, M., Lee, G. L., Nathubhai, A., Petrova, Y., Threadgill, M., James, T., Woodman, T. and Lloyd, M., 2016. A Convenient Colorimetric Assay For Alpha-Methylacyl-CoA Racemase (AMACR; P504S) And Testing Of Inhibitors. In: RICT 2016 Interfacing Chemical Biology and Drug Discovery, 2016-07-06 - 2016-09-08.

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2016. A convenient colorimetric assay for alpha-methylacyl-CoA racemase (AMACR; P504S) and testing for inhibitors.

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2016. A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors. In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath.

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. and Lloyd, M., 2016. A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing. In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath.

Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. and Lloyd, M., 2016. High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S). In: Cancer Research @ Bath 13th symposium, 2016-04-27 - 2016-04-27, University of Bath.

McKeown, P., Davidson, M.G., Lowe, J. P., Mahon, M. F., Thomas, L. H., Woodman, T. J. and Jones, M. D., 2016. Aminopiperidine based complexes for lactide polymerisation. Dalton Transactions, 45 (12), pp. 5374-5387.

Parker, H. J., Chuck, C. J., Woodman, T. and Jones, M. D., 2016. Degradation of a β-O-4 model lignin species by vanadium Schiff-base catalysts:influence of catalyst structure and reaction conditions on activity and selectivity. Catalysis Today, 269, pp. 40-47.

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T. D., Woodman, T. J. and Lloyd, M. D., 2016. A study on the AMACR catalysed elimination reaction and its application to inhibitor testing. Organic and Biomolecular Chemistry, 14 (2), pp. 612-622.

Parveen, I., Donnison, I. S., Insole, J., Winters, A. L., Dalton, S. J., Woodman, T. and Threadgill, M., 2016. An efficient assay for ferulic acid esterase and para-coumaric acid esterases in plants at physiologically relevant activities. Chemistry & Biology Interface, 6 (5), pp. 300-311.

Jevglevskis, M., Lee, G. L., Nathubhai, A., James, T., Threadgill, M., Woodman, T. and Lloyd, M., 2015. A Convenient Colorimetric Assay for α-Methylacyl-CoA Racemase (AMACR; P504S) and Testing Of Inhibitors. In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W.

Jevglevskis, M., Lee, G. L., Sun, J., Zhou, S., Sun, X., Kociok-Kohn, G., James, T., Woodman, T. and Lloyd, M., 2015. A Study On The α-Methylacyl-CoA Racemase (AMACR) Elimination Reaction And Its Application To Inhibitor Testing. In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W.

Petrova, Y., Matan, H., Lee, G. L., Jevglevskis, M., Woodman, T. and Lloyd, M., 2015. High-throughput screening to identify novel inhibitors of human α-methylacyl-CoA racemase 1A (AMACR; P504S). In: Cancer Research @ Bath symposium, 2015-11-11 - 2015-11-11, University of Bath, Claverton Down cmpus, builidng 5W.

Lloyd, Matthew, 2015. Methods (AMACR):None. C122Q 1/533- WO 2015 /114383 A1, 06 August 2015.

Jones, M., Brady, L., Mckeown, P. M., Buchard, A., Schafer, P. M., Thomas, L. H., Mahon, M. F., Woodman, T. J. and Lowe, J. P., 2015. Metal influence on the iso- and hetero-selectivity of complexes of bipyrrolidine derived Salan ligands for the polymerisation of rac-lactide. Chemical Science, 6 (8), pp. 5034-5039.

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: European School of Medicinal Chemistry, 2015-06-28 - 2015-07-03.

Lee, G. L., Jevglevskis, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: SET for Britain, 2015-03-09 - 2015-03-09, House of Commons.

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: 10th CR@B (Cancer Research at Bath) symposium, 2014-11-12 - 2014-11-12, University of Bath.

Lee, G. L., Jevglevskis, M., Threadgill, M., Woodman, T. and Lloyd, M., 2015. New routes to fight castrate-resistant prostate cancer: targeting α-methylacyl-CoA racemase (AMACR). In: 12th Winter Conference on Medicinal & Bioorganic Chemistry, 2015-01-25 - 2015-01-29, Steamboat springs resort.

Lloyd, Matthew, 2015. None. US 15/115,851, 2015.

Cybulski, M. K., Riddlestone, I. M., Mahon, M. F., Woodman, T. J. and Whittlesey, M. K., 2015. Stoichiometric and catalytic C-F bond activation by the trans-dihydride complex [Ru(IEt2Me2)2(PPh3)2H2] (IEt2Me2 = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene). Dalton Transactions, 44 (45), pp. 19597-19605.

Jevglevskis, M., Lee, G. L., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2014. The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S). Chemical Communications, 50 (91), pp. 14164-14166.

Hathout, R. M. and Woodman, T. J., 2014. NMR diffusion-ordered spectroscopy can explain differences in skin penetration enhancement between microemulsion formulations. Nanomedicine: Nanotechnology, Biology, and Medicine, 10 (7), pp. 1389-1390.

Forder, T. R., Mahon, M. F., Davidson, M. G., Woodman, T. and Jones, M. D., 2014. Synthesis and characterisation of unsymmetrical Zr(iv) amine tris(phenolate) complexes and their application in ROP of rac-LA. Dalton Transactions, 43 (31), pp. 12095-12099.

Jevglevskis, M., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2014. A novel elimination reaction catalysed by human alpha-methylacyl-CoA racemase (AMACR; P504S) and potential applications for measuring enzyme activity. In: Early Career Researchers Day, Prostate Cancer UK, 2014, 2014-03-20.

Jevglevskis, M., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2014. A novel elimination reaction catalysed by human alpha-methylacyl-CoA racemase (AMACR; P504S) and potential applications for measuring enzyme activity. In: RSC Chemical Biology and Bio-Organic Chemistry Postgraduate Symposium, 2014, 2014-04-01, University of Warwick.

Jevglevskis, M., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2014. A novel elimination reaction catalysed by human alpha-methylacyl-CoA racemase (AMACR; P504S) and potential applications for measuring enzyme activity. In: Oslo Prostate Cancer Symposium, University of Oslo, Norway, 2014-05-14 - 2014-05-16, University of Oslo.

Qu, X., Allan, A., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2013. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens. Biochemical Pharmacology, 86 (11), pp. 1621-1625.

Lloyd, M. D., Jevglevskis, M., Lee, G. L., Wood, P. J., Threadgill, M. D. and Woodman, T. J., 2013. α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S. Progress in Lipid Research, 52 (2), pp. 220-230.

Godage, H. Y., Riley, A. M., Woodman, T. J., Thomas, M. P., Mahon, M. F. and Potter, B. V. L., 2013. Regioselective opening of myo-inositol orthoesters:Mechanism and synthetic utility. Journal of Organic Chemistry, 78 (6), pp. 2275-2288.

Twum, E. A., Woodman, T. J., Wang, W. and Threadgill, M. D., 2013. Observation by NMR of cationic Wheland-like intermediates in the deiodination of protected 1-iodo-naphthalene-2,4-diamines in acidic media. Organic and Biomolecular Chemistry, 11 (36), pp. 6208-6214.

Hathout, R. M. and Woodman, T. J., 2012. Applications of NMR in the characterization of pharmaceutical microemulsions. Journal of Controlled Release, 161 (1), pp. 62-72.

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2012. Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2012. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Biochemical Society Conference,2012, 2012-01-01.

Qu, X., Leung, A., Allan, A. C., Chui, G., Hutchings, T. J., Jiao, P., Johnson, L., Leung, W. Y., Li, P. K., Steel, G. R., Thompson, A. S., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2012. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human Acyl-CoA thioesterases 1 and 2. In: Biochemical Society Conference,2012, 2012-01-01.

Nathubhai, A., Patterson, R., Woodman, T. J., Sharp, H. E. C., Chui, M. T. Y., Chung, H. H. K., Lau, S. W. S., Zheng, J., Lloyd, M. D., Thompson, A. S. and Threadgill, M. D., 2011. N3-Alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides. Organic and Biomolecular Chemistry, 9 (17), pp. 6089-6099.

Woodman, T. J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Steel, G. R., Jiao, P., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)-a potential mechanism for the anti-cancer effects of ibuprofen. Chemical Communications, 47 (26), pp. 7332-7334.

Woodman, T.J., Wood, P. J., Thompson, A. S., Hutchings, T. J., Jiao, P., Steel, G. R., Threadgill, M. D. and Lloyd, M. D., 2011. Chiral inversion of NSAID-CoA esters by human ∝-methylacyl-CoA racemase. In: Cancer Research @ Bath Conference, 2011, 2011-05-01.

Hathout, R. M., Woodman, T. J., Mansour, S., Mortada, N. D., Geneidi, A. S. and Guy, R. H., 2010. Microemulsion formulations for the transdermal delivery of testosterone. European Journal of Pharmaceutical Sciences, 40 (3), pp. 188-196.

Sattar, F. A., Darley, D. J., Politano, F., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2010. Unexpected stereoselective exchange of straight-chain fatty acyl-CoA α-protons by human α-methylacyl-CoA racemase 1A (P504S). Chemical Communications, 46 (19), pp. 3348-3350.

Darley, D. J., Butler, D. S., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Woodman, T. J., Threadgill, M. D. and Lloyd, M. D., 2009. Synthesis and use of isotope-labelled substrates for a mechanistic study on human α-methylacyl-CoA racemase 1A (AMACR; P504S). Organic and Biomolecular Chemistry, 7 (3), pp. 543-552.

Sattar, F. A., Darley, D., Politano, F., Woodman, T., Threadgill, M. and Lloyd, M., 2009. Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase. In: Cancer Research @ Bath Conference, 2011, 2011-05-01.

Sattar, F. A., Darley, D., Politano, F., Woodman, T., Threadgill, M. and Lloyd, M., 2009. Acyl-CoA ∝-proton exchange by ∝-methylacyl-CoA racemase. In: XVIIth Eurpoean Conference of GP2A (Groupement des Pharmacochimistes de L'Arc Atlantique), 2009-09-03.

Blagbrough, I. S., Elmasry, M. S., Woodman, T. J., Saleh, H. M. and Kheir, A. A., 2009. Quantitative determination of mebeverine HCl by NMR chemical shift migration. Tetrahedron, 65 (25), pp. 4930-4936.

Sarazin, Y., Wright, J. A., Harding, D. A. J., Martin, E., Woodman, T. J., Hughes, D. L. and Bochmann, M., 2008. Synthesis and structures of new binuclear zinc alkyl, aryl and aryloxo complexes. Journal of Organometallic Chemistry, 693 (8-9), pp. 1494-1501.

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR.

Darley, D. J., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M. D., Woodman, T. J. and Lloyd, M. D., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with ∝-methylacyl-CoA racemase (AMACR. In: RSC Bioorganic Group Annual Post-Graduate Symposium P8, 2008, 2008-03-01.

Darley, D., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M., Woodman, T. and Lloyd, M., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with α-methylacyl-CoA racemase (AMACR). In: UCB Pharmacology Prize Lecture Poster Presentations, 2008-03-03 - 2008-03-03, University of Bath.

Darley, D., Prideaux, S. J., Thornton, T. W., Wilson, A. D., Threadgill, M., Woodman, T. and Lloyd, M., 2008. Synthesis of 2-[2H]-2-[13C]-S-2-methyldecanoyl-CoA and 13C NMR study of its reaction with α-methylacyl-CoA racemase (AMACR). In: RSC Bioorganic Group Annual Post-Graduate Symposium P8, 2008, 2008-03-01.

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