Department of Pharmacy and Pharmacology

Pharmacy & Pharmacology work recognised as highly cited paper

Thu Oct 23 17:03:00 BST 2014

A paper derived from work at Bath in Professor Barry Potter’s Medicinal Chemistry group in the Department of Pharmacy & Pharmacology has been distinguished as a “Highly Cited Paper” by Thomson Reuters ISI Web of Science.

The work, entitled "Steroid sulfatase: Molecular Biology, Regulation, and Inhibition” appeared in 2005 in the high impact journal Endocrine Reviews and describes the basis of work carried out to exploit the discovery of a new class of enzyme inhibitor based upon a new structural drug motif discovered at Bath. This was engineered into a molecular template and optimised chemically to become the anti-cancer drug Irosustat that has since been translated to human clinical trials in breast cancer, prostate cancer, endometrial cancer and endometriosis in both men and women.

the new drug target: Steroid SulfataseThe oral drug is termed a ‘ first-in-class’ agent, designed to block the production of oestrogen, which fuels cancer development in two-thirds of all breast cancer cases and elsewhere.

As of June 2014 this paper received enough citations to place it formally in the top 1% of the academic field of Biology & Biochemistry, based on a highly cited threshold for the field and publication year.

Professor Barry Potter said: “It’s fantastic to have been part of starting off a whole new field of work with close colleagues and to see such real evidence of international impact on the academic and clinical communities. We are all now looking forward beyond citation impact to seeing real progress in terms of human therapeutic benefit.”

Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition
M. J. Reed, A. Purohit, L. W. L. Woo, S. P. Newman, and B. V. L. Potter
Endocrine Reviews 2005 26:2 , 171-202

Image: the new drug target: Steroid Sulfatase