Department of Psychology

Dr Katherine Button


10West 2.23
Tel: +44 (0) 1225 385606

Twitter ResearchGate


My research focuses on the cognitive mechanisms that contribute to common mental health disorders such as anxiety and depression, and translating this to improve cognitive-based intervention for patients in primary care. I use experimental techniques from cognitive psychology and neuroscience to explore these mechanisms to inform how they may be modified to reduce anxiety and improve mood. I use epidemiological investigations to understand how dysfunctional cognitions arise. I also work with clinical data from randomised controlled trials to investigate factors associated with response to cognitive behavioural therapy.

In addition to my primary research, I am an advocate for improving the transparency and rigor of psychological research. I use meta-analytic techniques to explore systematic weakness in the evidence-base, and draw on best-practice across disciplines for solutions.

Research interests

  • Depression
  • Anxiety disorder
  • Cognitive mechanisms
  • Social evaluative learning
  • Cognitive therapy
  • Scientific rigor and meta-science


Jump to: Articles


Burt, T., Button, K. S., Thom, H. H.Z., Noveck, R. J. and Munafò, M. R., 2017. The Burden of the "False-Negatives" in Clinical Development:Analyses of Current and Alternative Scenarios and Corrective Measures. Clinical and Translational Science

Lewis, G., Kounali, D. Z., Button, K. S., Duffy, L., Wiles, N. J., Munafò, M. R., Harmer, C. J. and Lewis, G., 2017. Variation in the recall of socially rewarding information and depressive symptom severity:a prospective cohort study. Acta Psychiatrica Scandinavica, 135 (5), pp. 489-498.

Dumas-Mallet, E., Button, K. S., Boraud, T., Gonon, F. and Munafò, M. R., 2017. Low statistical power in biomedical science:a review of three human research domains. Royal Society Open Science, 4 (2), 160254.

Munafò, M. R., Nosek, B. A., Bishop, D. V. M., Button, K. S., Chambers, C. D., Percie Du Sert, N., Simonsohn, U., Wagenmakers, E.-j., Ware, J. J. and Ioannidis, J. P. A., 2017. A manifesto for reproducible science. Nature Human Behaviour, 1 (1), 0021.

Button, K. S., Bal, L., Clark, A. and Shipley, T., 2016. Preventing the ends from justifying the means:withholding results to address publication bias in peer-review. Psychology, 4 (1), 59.

Kounali, D. Z., Button, K. S., Lewis, G. and Ades, A. E., 2016. The relative responsiveness of test instruments can be estimated using a meta-analytic approach:an illustration with treatments for depression. Journal of Clinical Epidemiology, 77, pp. 68-77.

Button, K. S., 2016. Statistical rigor and the perils of chance. eNeuro, 3 (4).

Button, K. S., Karwatowska, L., Kounali, D., Munafò, M. R. and Attwood, A. S., 2016. Acute anxiety and social inference:An experimental manipulation with 7.5% carbon dioxide inhalation. Journal of Psychopharmacology

Dumas-Mallet, E., Button, K., Boraud, T., Munafo, M. and Gonon, F., 2016. Replication Validity of Initial Association Studies:A Comparison between Psychiatry, Neurology and Four Somatic Diseases. PLoS ONE, 11 (6), e0158064.

Rossi, R., Zammit, S., Button, K. S., Munafò, M. R., Lewis, G. and David, A. S., 2016. Psychotic experiences and working memory:a population-based study using signal-detection analysis. PLoS ONE, 11 (4), e0153148.

Button, K., Lawrence, N., Chambers, C. and Munafo, M., 2016. Instilling scientific rigor at the grassroots:consortium-based undergraduate psychology projects. The Psychologist, 29 (3), pp. 158-167.

Button, K. S., Lawrence, N. S., Chambers, C. D. and Munafò, M. R., 2016. Instilling scientific rigour at the grassroots. Psychologist, 29 (3), pp. 158-159.

Carnegie, R., Shepherd, C., Pearson, R. M., Button, K. S., Munafò, M. R., Evans, J. and Penton-Voak, I. S., 2016. Changing mothers' perception of infant emotion:a pilot study. Archives of Women's Mental Health, 19 (1), pp. 167-172.

Davies, S. J. C., Pearson, R. M., Stapinski, L., Bould, H., Christmas, D. M., Button, K. S., Skapinakis, P., Lewis, G. and Evans, J., 2016. Symptoms of generalized anxiety disorder but not panic disorder at age 15 years increase the risk of depression at 18 years in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort study. Psychological Medicine, 46 (1), pp. 73-85.

Button, K. S., Kounali, D., Wiles, N. J., Peters, T. J., Welton, N. J., Ades, A. E., Lewis, G. and Thomas, L., 2015. Minimal clinically important difference on the Beck Depression Inventory - II according to the patient's perspective. Psychological Medicine, 45 (15), pp. 1-11.

Button, K. S. and Munafò, M. R., 2015. Addressing risk of bias in trials of cognitive behavioral therapy. Shanghai Archives of Psychiatry, 27 (3), pp. 144-8.

Button, K. S., Kounali, D., Stapinski, L., Rapee, R. M., Lewis, G. and Munafò, M. R., 2015. Fear of negative evaluation biases social evaluation inference:evidence from a probabilistic learning task. PLoS ONE, 10 (4), e0119456.

Button, K. S., Turner, N., Campbell, J., Kessler, D., Kuyken, W., Lewis, G., Peters, T. J., Thomas, L. and Wiles, N., 2015. Moderators of response to cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care. Journal of Affective Disorders, 174, pp. 272-80.

Pearson, R. M., Heron, J., Button, K., Bentall, R. P., Fernyhough, C., Mahedy, L., Bowes, L. and Lewis, G., 2015. Cognitive styles and future depressed mood in early adulthood:the importance of global attributions. Journal of Affective Disorders, 171, pp. 60-67.

Munafò, M., Noble, S., Browne, W. J., Brunner, D., Button, K., Ferreira, J., Holmans, P., Langbehn, D., Lewis, G., Lindquist, M., Tilling, K., Wagenmakers, E. J. and Blumenstein, R., 2014. Scientific rigor and the art of motorcycle maintenance. Nature Biotechnology, 32 (9), pp. 871-873.

Green, A., Crawford, A., Button, K. S., Wiles, N., Peters, T. J., Nutt, D. and Lewis, G., 2014. Are multiple physical symptoms a poor prognostic factor or just a marker of depression severity?:Secondary analysis of the GenPod trial. Journal of Affective Disorders, 163, pp. 40-46.

Stapinski, L. A., Bowes, L., Wolke, D., Pearson, R. M., Mahedy, L., Button, K. S., Lewis, G. and Araya, R., 2014. Peer victimization during adolescence and risk for anxiety disorders in adulthood:a prospective cohort study. Depression and Anxiety, 31 (7), pp. 574-582.

Wiles, N., Thomas, L., Abel, A., Barnes, M., Carroll, F., Ridgway, N., Sherlock, S., Turner, N., Button, K., Odondi, L.'o., Metcalfe, C., Owen-Smith, A., Campbell, J., Garland, A., Hollinghurst, S., Jerrom, B., Kessler, D., Kuyken, W., Morrison, J., Turner, K., Williams, C., Peters, T. and Lewis, G., 2014. Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care:the CoBalT randomised controlled trial. Health Technology Assessment, 18 (31), 1-167, vii-viii.

Button, K. S. and Munafò, M. R., 2014. Incentivising reproducible research. Cortex, 51 (1), pp. 107-108.

Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J. and Munafò, M. R., 2013. Empirical evidence for low reproducibility indicates low pre-study odds. Nature Reviews Neuroscience, 14 (12), p. 877.

Button, K., Lewis, G., Penton-Voak, I. and Munafò, M., 2013. Social anxiety is associated with general but not specific biases in emotion recognition. Psychiatry Research, 210 (1), pp. 199-207.

Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J. and Munafò, M. R., 2013. Confidence and precision increase with high statistical power. Nature Reviews Neuroscience, 14 (8), p. 585.

Brembs, B., Button, K. and Munafò, M., 2013. Deep impact:Unintended consequences of journal rank. Frontiers in Human Neuroscience

Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J. and Munafò, M. R., 2013. Power failure:Why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience, 14 (5), pp. 365-376.

Button, K. S., Browning, M., Munafò, M. R. and Lewis, G., 2012. Social inference and social anxiety:Evidence of a fear-congruent self-referential learning bias. Journal of Behavior Therapy and Experimental Psychiatry, 43 (4), pp. 1082-1087.

Button, K. S., Lewis, G. and Munafò, M. R., 2012. Understanding emotion:Lessons from anxiety. Behavioral and Brain Sciences, 35 (3), p. 145.

Button, K. S., Wiles, N. J., Lewis, G., Peters, T. J. and Kessler, D., 2012. Factors associated with differential response to online cognitive behavioural therapy. Social Psychiatry and Psychiatric Epidemiology, 47 (5), pp. 827-33.

This list was generated on Sun Oct 22 19:56:35 2017 IST.

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