Aims & Learning Objectives:
To introduce students to fundamental aspects of the practical procedures involved in the synthesis of biologically active small molecules. An emphasis will be upon functional group recognition and interchange, and we will also illustrate the importance of the 3-dimensional structure in medicinal and biological chemistry. To report the results of a practical investigation in poster form. After taking this Unit the student should be able to evaluate and analyse the factors involved in simple synthetic transformations of common functional groups and also compare and contrast the 3-dimensional shapes of molecules with respect to their functional groups.
Content:
The topics covered in this practical course include a systematic understanding of key aspects of structural factors that affect reactivity, functional groups and their interconversion at practical and mechanistic levels, and stereochemistry in pharmaceutical and biological molecules. Preparation and analysis of drugs and their synthetic intermediates will be carried out. Successful students will have demonstrated an ability accurately to deploy established techniques of analysis and synthesis.
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