Department of Pharmacy & Pharmacology, Unit Catalogue 2008/09 |
PA40253 Applied pharmacokinetics and pharmacodynamics |
| Credits: 6 |
| Level: Masters |
| Semester: 2 |
| Assessment: CW 30%, EX 50%, OT 20% |
| Requisites: |
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Aims: The aims of this unit are to acquire an understanding of (a) recent advances on therapeutic drug monitoring and (b) individualized drug therapy based on pharmacokinetic, pharmacodynamic and pharmacogenomic principles.
Learning Outcomes: On successful completion of this unit, the student should be able to: (a) critically evaluate elements of clinical pharmacokinetics and pharmacodynamics that have substantial effect on therapeutic drug monitoring and drug therapy; (b) predict and analyze the effect of variability (disease, genetics, adherence, age etc.) on a therapy outcome; (c) derive individual pharmacokinetic parameters with the help of Pharmacokinetic & Pharmacodynamic software and the choice of the appropriate PK-PD model. Skills: Scientific skills: Data analysis and clinical interpretation. (T/F/A) Study skills, finding and handling information (T/F/A) Working with others (F). Problem solving (T/F/A). Content: Following an introduction and brief overview of earlier core units, a number of topics will be discussed in clinical pharmacokinetics and pharmacodynamics. This will include the scientific basis for therapeutic drug monitoring and individualized therapy. A first part will cover general principles of drug distribution, metabolism and excretion in an advance level. Next the variability caused by disease, age, obesity and diet will be examined. Finally, the PK-PD of monitored drugs will be discussed. |