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Department of Biology & Biochemistry, Unit Catalogue 2011/12


BB20020: Protein structure

Click here for further information Credits: 6
Click here for further information Level: Intermediate (FHEQ level 5)
Click here for further information Period: Semester 1
Click here for further information Assessment: EX 80%, PR 20%
Click here for further information Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Click here for further information Requisites: Before taking this unit you must take BB10003 and take BB10004 and take CH10088 and take CH10087
Click here for further information Description: Aims:
To provide basic understanding of the factors that cause a protein to fold and the properties of those folds. To explore current methods for determining protein structures, folds and assemblies.

Learning Outcomes:
After taking this course the student should be able to:
* Describe qualitatively the interactions that determine the native conformation of a protein and its stability.
* Describe the form, occurrence and function of protein folds
* Describe the process and application of spectroscopic and diffraction techniques to the investigation of molecular structures and assemblies.
* Compare the relative advantages and limitations of these techniques and the data they provide.
* Propose appropriate experiments for given structural questions.

Skills:
Learning and studying T/F/A, Written communication T/F/A, Numeracy & computation T/F/A, Laboratory skills T/F, Information technology T/F, Information handling & retrieval T/F/A, Working independently T/F, Group working T/F.

Content:
Principles of protein folding
Protein folds
Methods and application of X-ray crystallography
Methods and application of NMR spectroscopy
Application of structural data to medicine and drug discovery.
Click here for further informationProgramme availability:

BB20020 is Compulsory on the following programmes:

Department of Biology & Biochemistry
  • USBB-AFB02 : BSc (hons) Biochemistry (Full-time) - Year 2
  • USBB-AKB06 : BSc (hons) Biochemistry with Professional Placement (Full-time with Thick Sandwich Placement) - Year 2

BB20020 is Optional on the following programmes:

Department of Biology & Biochemistry
  • USBB-AFB05 : BSc (hons) Molecular and Cellular Biology (Full-time) - Year 2
  • USBB-AKB08 : BSc (hons) Molecular and Cellular Biology with Professional Placement (Full-time with Thick Sandwich Placement) - Year 2
  • RSBB-AFM19 : Integrated PhD Postgenomic Biosciences (Protein Structure & Function Route) (Full-time) - Year 1
  • TSBB-AFM19 : MRes Protein Structure and Function (Full-time) - Year 1
  • TSBB-AFM13 : MSc Protein Structure and Function (Full-time) - Year 1

NB. Programmes and units are subject to change at any time, in accordance with normal University procedures.