Department of Biology & Biochemistry, Unit Catalogue 2011/12 |
|
 Credits:
| 6 |
| Level:
| Intermediate (FHEQ level 5) |
| Period: |
Semester 1 |
| Assessment:
| EX 80%, PR 20% |
| Supplementary Assessment: | Like-for-like reassessment (where allowed by programme regulations) |
| Requisites:
| Before taking this unit you must take BB10003 and take BB10004 |
| Description:
| Aims: To provide a fundamental understanding of enzymes as catalysts, at a physio-chemical level, and to relate these molecular properties to their cellular functions. Learning Outcomes: After taking this course the student should be able to: * describe the relationship between protein structure, ligand binding and enzyme catalysis; * explain how enzymes achieve their high catalytic rates; * explain steady-state kinetics of enzyme-catalysed reactions, the nature of reversible inhibition, and the effects of temperature and pH; * describe and carry out the requirements of reliable enzyme assays; * explain allosteric regulation in the control of enzymes; * describe the organisation of cellular enzymes into multienzyme complexes and multifunctional enzymes; * describe the role of isoenzymes in cellular regulation, development and differentiation, and their application to diagnosis of disease; * describe and explain the role of coenzymes in enzyme catalysis. Skills: Learning and studying T/F/A, Written communication T/F/A, Numeracy & computation T/F/A, Laboratory skills T/F, Information technology T/F, Problem solving T/F, Information handling & retrieval T/F/A, Working independently T/F, Career preparation T/F. Content: Ligand binding; steady-state kinetics; inhibition; effects of temperature and pH; principles of enzyme assay; theories of catalysis; allostery; isoenzymes, multienzyme complexes; coenzyme chemistry. |
| Programme availability: |
BB20018 is Compulsory on the following programmes:Department of Biology & Biochemistry
BB20018 is Optional on the following programmes:Department of Biology & Biochemistry
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