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Department of Chemistry, Unit Catalogue 2011/12

CH40128: Topics in organic chemistry

Click here for further information Credits: 6
Click here for further information Level: Masters UG & PG (FHEQ level 7)
Click here for further information Period: Semester 1
Click here for further information Assessment: EX 100%
Click here for further information Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Click here for further information Requisites: Before taking this unit you must take CH20014 and take CH20078 or suitable courses from another university. In taking this unit you cannot take Stereoselective Organic Synthesis as a component of CH30061.
Click here for further information Description: Aims:
The aim of the unit is to give students a thorough grounding in the methods, strategies and reagents employed in modern stereoselective organic synthesis.

Learning Outcomes:
After studying this unit students should be able to:
* Analyse the stereochemical course of a variety of reactions.
* Describe reagent systems to effect a wide range of simple transformation.
* Appreciate why organoelement chemistry is used in synthesis.
* Describe a wide range of new synthetic transformations.
* Describe fully the mechanism of these reactions.
* Apply the information learnt to solve problems.
* Critically evaluate publications from the recent literature to illustrate the course themes.
* Demonstrate knowledge of selected recent developments in organic chemistry.

Problem solving (T, F, A), Scientific writing (F, A), Independent working (F), Group working (F).

The unit begins with a section concerned with the simple diastereoselection, focusing on the reactions of carbonyl and alkene systems. The concepts of allylic strain and directed reactions are introduced. The use of chiral auxiliaries to control the sterochemistry of organic reactions forms the second section. Particular systems studied include the use of SAMP and RAMP hydrozones and Evans' auxiliaries to control a range of chiral-enolate based bond constructions. The final section of the unit focuses on the development and application of practical enantioselective catalysts of particular relevance to the fine chemical industry. Examplse of transformations to be studied will include hydrogenation of double bonds, oxidations and carbon-carbon bond forming reactions. Organoboron chemistry. Organosilicon chemistry. Organophosphorus chemistry. Organosulphur chemistry. Organometallics in Organic synthesis. Carbonylation reactions. Coupling Reactions. Methods of C-C bond formation.
Click here for further informationProgramme availability:

CH40128 is Optional on the following programmes:

Department of Chemistry
  • USCH-AKM02 : MChem (hons) Chemistry with Industrial Training (Full-time with Thick Sandwich Placement) - Year 4
  • USCH-AAM03 : MChem (hons) Chemistry with Study Year Abroad (Full-time with Study Year Abroad) - Year 4
  • TSCH-AFM01 : MRes Chemistry (Full-time) - Year 1
  • TSCH-AFM04 : MSc Chemistry for Drug Discovery (Full-time) - Year 1
Programmes in Natural Sciences
  • UXXX-AFM01 : MSci (hons) Natural Sciences (Full-time) - Year 4

NB. Programmes and units are subject to change at any time, in accordance with normal University procedures.