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Department of Pharmacy & Pharmacology, Unit Catalogue 2011/12


PA20293: Gene transcription & DNA

Click here for further information Credits: 6
Click here for further information Level: Intermediate (FHEQ level 5)
Click here for further information Period: Semester 2
Click here for further information Assessment: EX100
Click here for further information Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Click here for further information Requisites: Before taking this unit you must take PA20292
Click here for further information Description: Aims:

* To familiarise the student with the mechanisms of transcriptional regulation and aberrations in these mechanisms and processes which lead to inherited diseases or the development of cancer;
* To provide basic understanding of recombinant DNA technology including the production of pharmaceutical products and as a research tool;
* To familiarise the student with the properties and potential of stem cells;
* To illustrate clinical cases through problem-based learning.

Learning Outcomes:
After taking this unit, the student will be able to:
* Describe the cellular pathways and mechanisms involved in the regulation of gene expression;
* Explain how genetic mutations can predispose to disease states;
* Demonstrate an understanding of recombinant DNA and stem cell technology;
* Appreciate the application of these technologies in pharmaceutical and biomedical science.

Skills:
Scientific and practical skills (T/F/A)
Study skills, handling information, working with others (T/F)
Problem solving (T/F).

Content:
Impact of signalling pathways on nuclear events including regulation of gene expression through transcription factor binding. Genetic mutations, oncogenes, tumour suppressor genes and the control of cell growth. DNA cloning and the use of vectors, including plasmids and viral vectors. Manipulation of DNA including the use of restriction enzymes, DNA sequencing, hybridisation techniques, polymerase chain reaction. Stem cells and molecular techniques - RNAi and gene therapy. Problem based learning applied to relevant clinical case studies.
Click here for further informationProgramme availability:

PA20293 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology

PA20293 is Compulsory on the following programmes:

Department of Pharmacy & Pharmacology
  • USPA-AFB02 : BSc (hons) Pharmacology (Full-time) - Year 2
  • USPA-AKB02 : BSc (hons) Pharmacology (Full-time with Thick Sandwich Placement) - Year 2
  • USPA-AKM02 : MPharmacology (hons) (Full-time with Thick Sandwich Placement) - Year 2

PA20293 is Optional on the following programmes:

Programmes in Natural Sciences
  • UXXX-AFB01 : BSc (hons) Natural Sciences (Full-time) - Year 2
  • UXXX-AKB02 : BSc (hons) Natural Sciences with Industrial Placement (Full-time with Thick Sandwich Placement) - Year 2
  • UXXX-AAB02 : BSc (hons) Natural Sciences with Study Year Abroad (Full-time with Study Year Abroad) - Year 2
  • UXXX-AFM01 : MSci (hons) Natural Sciences (Full-time) - Year 2
  • UXXX-AKM02 : MSci (hons) Natural Sciences with Professional Placement (Full-time with Thick Sandwich Placement) - Year 2
  • UXXX-AAM02 : MSci (hons) Natural Sciences with Study Year Abroad (Full-time with Study Year Abroad) - Year 2

NB. Programmes and units are subject to change at any time, in accordance with normal University procedures.