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Department of Pharmacy & Pharmacology, Unit Catalogue 2011/12

PA30244: Chemical aspects of drug design & discovery

Click here for further information Credits: 6
Click here for further information Level: Honours (FHEQ level 6)
Click here for further information Period: Semester 1
Click here for further information Assessment: EX 100%
Click here for further information Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Click here for further information Requisites: Before taking this unit you must take PA10236 or take PA10237
Click here for further information Description: Aims:
The aim of the Unit is to provide students with an understanding of the fundamentals of how drugs are designed and discovered, with a particular focus on molecular and structural aspects.

Learning Outcomes:
After completing the Unit, a student should be able to:
1. Recognise the different approaches to drug discovery and grasp the importance of each approach
2. Distinguish the different types of rationally designed inhibitors of enzymes
3. Use simple structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR) methods in rationalising data.

Data handling and analysis (T/F/A)
Handling information (F).

1. Classical SAR and QSAR
2. Selection of target for drug design and drug design based on knowledge of the structure of the target
3. Inhibition of enzyme activity
4. Affinity labelling
5. Examples of structure-based drug design
6. Combinatorial chemistry and high-throughput screening
7. Design of drugs to modulate signalling pathways.
Click here for further informationProgramme availability:

PA30244 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
NB. Programmes and units are subject to change at any time, in accordance with normal University procedures.