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PA20292: Immunology & receptor signalling

Follow this link for further information on academic years Academic Year: 2014/5
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 3
Further information on unit levels Level: Intermediate (FHEQ level 5)
Further information on teaching periods Period: Semester 1
Further information on unit assessment Assessment Summary: EX 100%
Further information on unit assessment Assessment Detail:
  • Examination (EX 100%)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites:
Further information on descriptions Description: Aims:

* To familiarise the student with the major families of receptors and the components of intracellular signalling pathways from receptor to cell nucleus.
* To introduce the major cellular and humoral components of the immune system and to illustrate its role in health and disease.
* To provide a basic understanding of the techniques used to detect protein expression.
* To illustrate clinical cases through problem-based learning.

Learning Outcomes:
After taking this unit, the student will be able to:
* List a variety of receptor families and outline their mechanism of activation and links to intracellular pathways;
* Describe the physiological role of the immune system;
* Apply knowledge of these pathways and systems to explain the underlying mechanisms which cause disease;
* Explain the uses and limitations of antibodies in the laboratory and in the diagnosis and treatment of disease.

Scientific and practical skills (T/F/A)
Study skills, handling information, working with others (T/F)
Problem solving (T/F).

Receptor families, second messenger systems, protein kinases and their phosphorylation targets. The innate and adaptive immune system - antibodies, T and B lymphocytes, antigen presenting cells and the MHC, effector functions, tolerance and autoimmunity. Use of protein detection assays and antibodies as laboratory, diagnostic and therapeutic agents.
Problem based learning applied to relevant clinical case studies.
Further information on programme availabilityProgramme availability:

PA20292 is Compulsory on the following programmes:

Department of Pharmacy & Pharmacology
  • USPA-AFB02 : BSc(Hons) Pharmacology (Year 2)
  • USPA-AKB02 : BSc(Hons) Pharmacology with Year long work placement (Year 2)
  • USPA-AKM02 : MPharmacol(Hons) Pharmacology with Year long work placement (Year 2)

PA20292 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology

PA20292 is Optional on the following programmes:

Programmes in Natural Sciences
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Year 2)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences with Study year abroad (Year 2)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences with Year long work placement (Year 2)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Year 2)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences with Professional Placement (Year 2)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences with Study year abroad (Year 2)

* This unit catalogue is applicable for the 2014/15 academic year only. Students continuing their studies into 2015/16 and beyond should not assume that this unit will be available in future years in the format displayed here for 2014/15.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.