- Student Records
Programme & Unit Catalogues

PA10306: Fundamentals of pharmacy: from molecules to medicines 1

Follow this link for further information on academic years Academic Year: 2015/6
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 12
Further information on unit levels Level: Certificate (FHEQ level 4)
Further information on teaching periods Period: Semester 1
Further information on unit assessment Assessment Summary: EX 100%
Further information on unit assessment Assessment Detail:
  • EXAMINATION (EX 100% - Qualifying Mark: 40)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: While taking this module you must take PA10307 AND take PA10308 AND take PA10309 AND take PA10310
Further information on descriptions Description: Aims:
To enable the student to understand the fundamental chemical, physicochemical and biological concepts underpinning pharmacy from the sub-atomic to the cellular level.

Learning Outcomes:
After completing this unit, the student pharmacist will be able to:
* Describe factors that affect the 3-dimensional shape of molecules and assign stereochemical descriptions;
* Present reaction mechanisms for the inter-conversion of common functional groups and outline how these functional groups mediate acidity, basicity and bonding interactions;
* Appreciate how physiochemical properties of a molecule influence its behaviour as a drug; recognise the different approaches to drug discovery and grasp the importance of each;
* Distinguish the different types of drug classes and describe the methods used in their development.

Scientific and practical skills (T/F/A)
Study skills, handling information, working with others (T/F)
Problem solving (T/F/A).


* From molecules to medicines - the concepts
* Orbital theory, electron configurations and hybridisation
* Introduction to isotopes, radioactivity and radioactive decay
* Bonding (covalent, ionic, hydrogen, intermolecular)
* Electron density, inductive effects and electronegativity
* Systematic nomenclature of small molecules
* Calculation of yields, moles and concentrations
* Functional groups and their conversions (substitution, elimination)
* Structural isomers and configuration
* Geometrical isomers (polarity, +/-, racemisation)
* Recognition and assignment of chirality, relevance to drugs and receptors
* Carbonyl group chemistry and biochemistry
* Reactions of carbonyl groups
* Fundamentals of acids and bases (pKa, enolates)
* Alkylation and acylation reactions of enols and enolates
* Biochemistry and reactions of esters
* Biochemistry and reactions of amides
* Reactions of alkenes (electrophilic and nucleophilic)
* Aromatic groups (properties, reactions and biochemistry)
* Introduction to oxidation reactions
* Introduction to reduction reactions
* Fundaments of radioisotope decay. Radioisotopes as drugs and markers.
* Concepts of drugs, medicines and active pharmaceutical ingredients
* Importance of physiochemical properties to small molecule drugs (molecular weight, pKa, solubility, log P, Lipinski rules)
* Drawing and recognising drug structures. Apply nomenclature to selected drug molecules
* Molecular (chemical) basis for drug degradation
* Overview of drug targets in bacteria, virus and cancer
* Introduction to the drug discovery pipeline and regulatory requirements
* Examples of natural products as drugs
* Modern drug discovery pipeline
* Examples of rational drug discovery
* Case studies of modern drug discovery techniques and examples of modern drug design
* Introduction to biological drugs and emerging drug technologies.
Further information on programme availabilityProgramme availability:

PA10306 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
* This unit catalogue is applicable for the 2015/16 academic year only. Students continuing their studies into 2016/17 and beyond should not assume that this unit will be available in future years in the format displayed here for 2015/16.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.