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PA20285: Medicines design 1: liquid and semisolid pharmaceutical dosage forms

Follow this link for further information on academic years Academic Year: 2015/6
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 6
Further information on unit levels Level: Intermediate (FHEQ level 5)
Further information on teaching periods Period: Semester 1
Further information on unit assessment Assessment Summary: EX 100%, OT 0%, PR 0%
Further information on unit assessment Assessment Detail:
  • Examination (EX 100%)
  • Practical (PR 0%)
  • Workshops attendance (OT 0%)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this module you must take PA10281
Further information on descriptions Description: Aims:
To learn about liquid and semisolid dosage forms, their manufacturing process and their use in drug therapy.

Learning Outcomes:
By the end of the unit the student will be able to:
1. Explain the concepts of solubility, dissolution and dissolution rate and illustrate their relevance in pharmaceutical dosage forms. Formulate and contrast the methods used to solubilise drugs.
2. Explain the phenomena of surface and interfacial tension, wetting, and adsorption. Illustrate their relevance in pharmaceutical technology.
3. Explain what surfactants and polymers are and their use in pharmaceutical technology. Explain and apply the concepts of HLB and critical micellar concentration. List the most commonly used surfactants and polymers. Contrast their advantages and limitations.
4. Explain the concepts of osmolarity and isotonicity and their application in pharmaceutical dosage forms.
5. Explain the phenomena of rheology. Illustrate its relevance in pharmaceutical dosage forms.
6. Explain the technological process involved in the formulation of emulsions, suspensions and ointments and evaluate the critical parameters involved in their stability.
7. Contrast microemulsion, liposome and gel pharmaceutical formulations. List the most commonly used excipients, and the critical parameters involved in the production, stability, safety and efficacy.
8. Contrast the different liquid and semi-solid dosage forms used in pharmacy. List the most commonly used excipients and the critical parameters involved in the production, stability, safety and efficacy of liquid and semi-solid dosage forms. Explain the requirements and tests that each type of dosage form must met and relate them to their performance and route of administration (oral, ophthalmic, parenterals).

1. Scientific and practical skills
2. Planning and organization
3. Working with others
4. Problem solving and data analysis
5. Handling information
6. Analytical thinking
7. Professional skills
All taught and assessed.

1. Solubility, dissolution and dissolution rate. Methods for drug solubilisation: co-solvents, cyclodextrins, surfactants. Revison: pH-pKa: salt-formation and pH of precipitation.
2. Surface and interfacial tension. Wetting and adsorption phenomena. Tensio-actives and their properties. Concept of critical micellar concentration and HLB and their application.
3. Pharmaceutical polymers.
4. Osmolarity and isotonicity. Adjustment of isotonicity
5. Concept of rheology. Rheological properties of liquid and semi-solid dosage forms
6. Pharmaceutical disperse and colloidal systems (emulsions, suspensions, microemulsions, liposomes, gels). Other semisolid forms (ointments, pastes).
7. Pharmaceutical liquid and semisolid dosage forms. Their use for the parenteral, oral, ophthalmic and otic routes of drug delivery.
Further information on programme availabilityProgramme availability:

PA20285 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
* This unit catalogue is applicable for the 2015/16 academic year only. Students continuing their studies into 2016/17 and beyond should not assume that this unit will be available in future years in the format displayed here for 2015/16.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.