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PA30244: Chemical aspects of drug design & discovery

Follow this link for further information on academic years Academic Year: 2015/6
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 6
Further information on unit levels Level: Honours (FHEQ level 6)
Further information on teaching periods Period: Semester 1
Further information on unit assessment Assessment Summary: EX 100%
Further information on unit assessment Assessment Detail:
  • Examination (EX 100%)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this module you must take PA10237
Further information on descriptions Description: Aims:
The aim of the Unit is to provide students with an understanding of the fundamentals of how drugs are designed and discovered, with a particular focus on molecular and structural aspects.

Learning Outcomes:
After completing the Unit, a student should be able to:
1. Recognise the different approaches to drug discovery and grasp the importance of each approach.
2. Distinguish the different types of rationally designed inhibitors of enzymes.
3. Use simple structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR) methods in rationalising data.

Data handling and analysis (T/F/A)
Handling information (F).

1. Classical SAR and QSAR
2. Selection of target for drug design and drug design based on knowledge of the structure of the target
3. Inhibition of enzyme activity
4. Affinity labelling
5. Examples of structure-based drug design
6. Combinatorial chemistry and high-throughput screening
7. Design of drugs to modulate signalling pathways
8. Structure-based molecular modelling.
Further information on programme availabilityProgramme availability:

PA30244 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
* This unit catalogue is applicable for the 2015/16 academic year only. Students continuing their studies into 2016/17 and beyond should not assume that this unit will be available in future years in the format displayed here for 2015/16.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.