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PA30286: Medicines design 2: solid dosage forms

Follow this link for further information on academic years Academic Year: 2015/6
Further information on owning departmentsOwning Department/School: Department of Pharmacy & Pharmacology
Further information on credits Credits: 6
Further information on unit levels Level: Honours (FHEQ level 6)
Further information on teaching periods Period: Semester 1
Further information on unit assessment Assessment Summary: EX 100%, OT 0%, PR 0%
Further information on unit assessment Assessment Detail:
  • Examination (EX 100%)
  • Practicals (PR 0%)
  • Workshops attendance (OT 0%)
Further information on supplementary assessment Supplementary Assessment: Like-for-like reassessment (where allowed by programme regulations)
Further information on requisites Requisites: Before taking this module you must take PA10281 AND take PA20285
Further information on descriptions Description: Aims:
To learn about the solid oral dosage forms, their manufacturing process and their use in drug therapy.

Learning Outcomes:
By the end of the unit the student will be able to:
1. Compare and contrast the gastro-intestinal, colonic and rectal routes of drug delivery. Analyse which route of administration is more appropriate for a given drug therapy. Illustrate the requirements imposed to medicines by the desired route of administration.
2. Compare and contrast the following dosage forms: powders, granules, tablets, capsules, and lozenges.
3. Illustrate the technological process involved in the formulation of solid oral dosage forms. List the most commonly used excipients, and evaluate the critical parameters involved in the production, stability, safety and efficacy of solid oral dosage forms. Examine the requirements and tests that each type of dosage form must met and relate them to their performance.
4. Examine the role of preformulation (crystals, salts and polymorphs), calorimetry and micromeritics in pharmaceutical development and the performance of dosage forms.
5. Examine the role of IVIVC in pharmaceutical development.
6. Explain what pharmacopoeias are and their use in pharmacy and pharmaceutical sciences.
7. Explain the technological process and list excipients involved in the formulation of suppositories. Explain the critical parameters involved in their production, stability and relate them to their performance and to the characteristics of the rectal route of drug delivery. Apply the concept of displacement factor.
8. Illustrate how medicines are labelled and packed.
9. Demonstrate the significance of GMP in pharmaceutical industry.

1. Practical skills
2. Planning and organization
3. Working with others
4. Problem solving
5. Handling information
6. Analytical thinking
All taught and assessed.

1. Introduction. The medicine development process. Blockbusters.
2. Comparative overview of routes of the oral, colonic and rectal routes of drug administration. Physiological aspects that determine drug absorption and disposition. Importance of the dosage form.
3. Preformulation (salts, crystal, polymorphs and case studies in preformulation)
4. Micromeritcs and calorimetry in pharmaceutical development
5. Excipients
6. Oral solid dosage forms: powders, granules, tablets, capsules, lozenges, advanced oral drug delivery systems.
7. Pharmacopeias. Tests on oral solid dosage forms. Dissolution. IVIVC.
8. Formulation of suppositories. Rectal drug delivery
9. Packaging and labelling. GMP
Further information on programme availabilityProgramme availability:

PA30286 is a Designated Essential Unit on the following programmes:

Department of Pharmacy & Pharmacology
* This unit catalogue is applicable for the 2015/16 academic year only. Students continuing their studies into 2016/17 and beyond should not assume that this unit will be available in future years in the format displayed here for 2015/16.
* Programmes and units are subject to change at any time, in accordance with normal University procedures.
* Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.