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CH10135: Fundamentals of organic chemistry

[Page last updated: 20 April 2021]

Academic Year: 2021/2
Owning Department/School: Department of Chemistry
Credits: 12      [equivalent to 24 CATS credits]
Notional Study Hours: 240
Level: Certificate (FHEQ level 4)
Period:
Academic Year
Assessment Summary: EX 100%
Supplementary Assessment:
CH10135 Supplementary Assessment (where allowed by programme regulations)
Requisites: In taking this module you cannot take CH10136
Aims: To introduce the basic concepts upon which the understanding of organic chemistry depends, including structure, bonding and mechanism (arrow pushing) in the context of key reactions of organic chemistry. To build upon these basics to develop the concepts and knowledge essential to a sound understanding of modern organic chemistry, including the characteristic properties of organic functional groups (FGs), their interconversions, and their spectroscopic identification.

Learning Outcomes: After studying this unit, students should be able to:
* Describe the structure and bonding of simple organic molecules in order to explain their chemical behaviour.
* Apply nomenclature, notation and diagrams to describe structures and reactions.
* Describe and explain the general properties, reactions, mechanisms and methods of synthesis for monofunctionalised aliphatic and compounds.
* Describe and explain the mechanisms of nucleophilic aliphatic substitution and elimination reactions and of electrophilic addition to alkenes.
* Describe and explain the mechanisms of nucleophilic addition and substitution reactions of the carbonyl group and condensation reactions.
* Demonstrate the stability of aromatic compounds and compare their reactivity with that of alkenes and carbonyls in a practical sense.
* Apply the methodology of FG interconversions in the synthesis of academically and commercially important target molecules.
* Elucidate the structures of simple organic molecules using a range of spectroscopic techniques.
* Select appropriate techniques (IR, NMR and UV and mass spectroscopy) to identify organic compounds in a range of situations.
* Solve characterisation problems in organic spectroscopy.

Skills: Numeracy (F, A), Problem solving (T, F, A), Scientific writing (F, A), Oral communication (F).

Content: Lewis structures, resonance, orbitals and hybridisation, conjugation, hyperconjugation. Conformation and configuration; enantiomers, diastereomers, geometric isomers. Acids and bases, pKas. Solvation. Stability and equilibrium. Kinetics and reaction energy profiles.
Characteristic reactions of alkenes and haloalkanes: mechanisms for electrophilic addition to alkenes; aliphatic nucleophilic substitution (e.g. SN1, SN2) and elimination (e.g. E1, E2).
Concepts of carbonyl chemistry: nucleophilic addition and addition-elimination reactions; oxidation and reduction; carboxylic acid derivatives (e.g. acid chlorides, amides); enolate chemistry.
Properties, synthesis and interconversion reactions of alcohols, ethers, amines, ketones, aldehydes, and carboxylic acids with their derivatives. Mechanism and applications in synthesis.
Similarities and differences between aliphatic and aromatic compounds. Introduction to aromaticity. Hückel's rule. Electrophilic aromatic substitution.
Nucleophilic attack on aromatic rings; applications in synthesis.
IR spectra of functional group containing compounds. Origins and applications of proton and carbon NMR spectra. Elucidating structures from spectra.

Programme availability:
NB. Postgraduate programme information will be added when the postgraduate catalogues are published in August 2021

CH10135 is Compulsory on the following programmes:

Department of Chemistry
  • USCH-AFB01 : BSc(Hons) Chemistry (Year 1)
  • USCH-AAB02 : BSc(Hons) Chemistry with Study year abroad (Year 1)
  • USCH-AFB07 : BSc(Hons) Chemistry for Drug Discovery (Year 1)
  • USCH-AAB08 : BSc(Hons) Chemistry for Drug Discovery with Study year abroad (Year 1)
  • USCH-AKB08 : BSc(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 1)
  • USCH-AKB02 : BSc(Hons) Chemistry with Industrial Placement (Year 1)
  • USCH-AFB03 : BSc(Hons) Chemistry with Management (Year 1)
  • USCH-AAB04 : BSc(Hons) Chemistry with Management with Study year abroad (Year 1)
  • USCH-AKB04 : BSc(Hons) Chemistry with Management with Industrial Placement (Year 1)
  • USCH-AFM02 : MChem(Hons) Chemistry (Year 1)
  • USCH-AAM03 : MChem(Hons) Chemistry with Study year abroad (Year 1)
  • USCH-AFM05 : MChem(Hons) Chemistry for Drug Discovery (Year 1)
  • USCH-AAM06 : MChem(Hons) Chemistry for Drug Discovery with Study year abroad (Year 1)
  • USCH-AKM03 : MChem(Hons) Chemistry for Drug Discovery with Industrial Placement (Year 1)
  • USCH-AKM02 : MChem(Hons) Chemistry with Industrial Placement (Year 1)
  • USCH-AFM07 : MSci(Hons) Chemistry with Management (Year 1)
  • USCH-AKM07 : MSci(Hons) Chemistry with Management with Industrial Placement (Year 1)

CH10135 is Optional on the following programmes:

Programmes in Natural Sciences
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biochemistry with Environmental Science stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biology with Chemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biology with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biology with Chemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biology with Environmental Science stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biology with Environmental Science stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biology with Environmental Science stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Biology with Pharmacology stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Biology with Pharmacology stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Biology with Pharmacology stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Biology stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Biology stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Biology stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Environmental Science stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Chemistry with Physics stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Chemistry with Physics stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Chemistry with Physics stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Environmental Science with Biochemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Biology stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Environmental Science with Biology stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Environmental Science with Biology stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Environmental Science with Chemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Environmental Science with Physics stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Environmental Science with Physics stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Environmental Science with Physics stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Pharmacology with Biochemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Biology stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Pharmacology with Biology stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Pharmacology with Biology stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Pharmacology with Chemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Physics with Chemistry stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Physics with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Physics with Chemistry stream) with Year long work placement (Year 1)
  • UXXX-AFB01 : BSc(Hons) Natural Sciences (Physics with Environmental Science stream) (Year 1)
  • UXXX-AAB02 : BSc(Hons) Natural Sciences (Physics with Environmental Science stream) with Study year abroad (Year 1)
  • UXXX-AKB02 : BSc(Hons) Natural Sciences (Physics with Environmental Science stream) with Year long work placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biochemistry with Chemistry stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biochemistry with Pharmacology stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biology with Chemistry stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Biology with Pharmacology stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Biology with Pharmacology stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Biology with Pharmacology stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biochemistry stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Biology stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Pharmacology stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Chemistry with Physics stream) with Professional Placement (Year 1)
  • UXXX-AFM01 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) (Year 1)
  • UXXX-AAM02 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Study year abroad (Year 1)
  • UXXX-AKM02 : MSci(Hons) Natural Sciences (Physics with Chemistry stream) with Professional Placement (Year 1)

Notes:

  • This unit catalogue is applicable for the 2021/22 academic year only. Students continuing their studies into 2022/23 and beyond should not assume that this unit will be available in future years in the format displayed here for 2021/22.
  • Programmes and units are subject to change in accordance with normal University procedures.
  • Availability of units will be subject to constraints such as staff availability, minimum and maximum group sizes, and timetabling factors as well as a student's ability to meet any pre-requisite rules.
  • Find out more about these and other important University terms and conditions here.