PA10312: Fundamentals of pharmacology: the healthy body 1
[Page last updated: 05 August 2021]
| Academic Year: | 2021/2 |
| Owning Department/School: | Department of Pharmacy & Pharmacology |
| Credits: | 12 [equivalent to 24 CATS credits] |
| Notional Study Hours: | 240 |
| Level: | Certificate (FHEQ level 4) |
| Period: |
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| Assessment Summary: | EX 100% |
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| Requisites: | While taking this module you must take PA10311 AND take PA10313 AND take PA10314 |
| Description: | Aims: To provide the student with an understanding of the normal structure and function of the cells and tissues comprising the major physiological systems of the healthy human body, their integration and regulation, as the basis for the later study of physiological function relevant to pharmacology. To provide the student with an introduction to the concepts of drug action within living systems at a molecular and cellular level. Learning Outcomes: After taking this unit, the student should be able to: * Define health and illness and the physiological concept of homeostasis * Describe the normal structure and function of human cells at a molecular, cellular and tissue level * Demonstrate a foundation knowledge of the differences between bacterial, viral, fungal cells and principles of infection mechanisms * Explain the principles of the molecular basis of drug action within living systems at a molecular and cellular level (pharmacology) * Use relevant pharmacological calculations to determine the potency of agonist and antagonist drug action. Skills: Scientific and practical skills (T/F/A) Study skills, handling information, working with others (T/F) Problem solving (T/F/A). Content: * What is health? * What is a healthy body (Introduction to cell, tissues, and systems)? * What is a cell? - Structure, function, membranes and organelles of the human cell. * Lipids / cell membranes, Proteins - amino acids & peptides * Transporters, enzymes, receptors - cell to cell * Introductions to bacterial cells, human microflora & infections, viral cells & infections, protozoa & fungi, human microbiome & defences * Intro to pharmacology & receptor theory, agonists - EC50 - efficacy, co-operativity. antagonists - comp / non- comp IC50, Schild plots * Introduction to pharmacodynamics * Enzymes as catalysts. Enzyme role in drug metabolism. * Enzymes as drug targets - Km, Vmax * Nucleosides / tides, nucleic acids, nucleic acid biosynthesis * DNA replication prokaryotes / eukaryotes * Transcription to translation - drug targets * Carbohydrates - cellular functions * Anatomy of the nervous system, nerve cells - membrane potential, communication - chemical transmission & synapses, the brain, the autonomic nervous system * Reflexes and senses (touch) * Ears and eyes (Anatomy and function) * Nose and throat (Anatomy and function) * Blood cells, blood formation & clotting * Skeletal, cardiac and smooth muscle * The gastrointestinal system: anatomy, function, digestion. |
| Programme availability: |
PA10312 is Compulsory on the following programmes:Department of Pharmacy & Pharmacology
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